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[null,"1.","Record Nr.",null,"UNINA9910450847803321"]
[null,null,"Titolo",null,"Virtual ADMET assessment in target selection and maturation [[electronic resource] /] / edited by B. Testa and L. Turski"]
[null,null,"Pubbl/distr/stampa",null,"Amsterdam ; ; Washington, DC, : IOS Press, c2006"]
[null,null,"ISBN",null,"1-280-81056-4"]
[{"$nulls":4},"9786610810567"]
[{"$nulls":4},"1-4294-6772-X"]
[{"$nulls":4},"1-60750-219-4"]
[{"$nulls":4},"600-00-0604-7"]
[{"$nulls":4},"1-4337-0155-3"]
[null,null,"Descrizione fisica",null,"1 online resource (268 p.)"]
[null,null,"Collana",null,"Solvay Pharmaceuticals Conferences, , 1566-7685 ; ; v. 6"]
[null,null,"Disciplina",null,"615/.190285"]
[null,null,"Soggetti",null,"Drug development - Computer simulation"]
[{"$nulls":4},"Pharmacology"]
[{"$nulls":4},"Electronic books."]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Organized May 11-13th, 2005 in Lucerne, Switzerland."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Preface; List of Contributors; Contents; Conference Preface; The Risky Business of Developing Drugs; Benefits and Limits of in Silico Predictions; Musings on ADME Predictions and Molecular Structure; Lipophilicity: Its Calculation and Application in ADMET Predictions; Interpretation of the Role of the Electrotopological State and Molecular Connectivity Indices in the Prediction of Physical Properties and ADME-Tox Behavior - Case Study: Human Plasma Protein Binding; Molecular Descriptors for Predicting ADMET Properties; Molecular Fields to Assess Recognition Forces and Property Spaces"]
[{"$nulls":4},"Extracting Pharmacophores from Bio-Active MoleculesIn Silico Models for Human Bioavailability; In Silico Models to Predict Brain Uptake; Algorithms to Predict Affinity for Transporters; Predicting Affinity for and Metabolism by Cytochromes P450; Expert Systems to Predict Biotransformation; Expert Systems to Predict Toxicity; From in Vivo to in Vitro/in Silico ADME: Progress and Challenges; Author Index"]
[null,null,null,"Sommario/riassunto","Today, biologists and medicinal chemists realize that there is a strong relationship between pharmacodynamic (what the drug does to the organism) and pharmacokinetic (what the organism does to the drug) "]
[{"$nulls":4},"effects. A significant contributing factor to the evolution in drug discovery was the methodological and technological revolution with the advent of combinatorial chemistry, high-throughput screening and profiling, and in silico prediction of target-based activity and ADMET (absorption, distribution, metabolism, excretion and toxicity) properties. High-throughput screening and in silico methods"]
[null,"2.","Record Nr.",null,"UNINA9910783570503321"]
[null,null,"Autore",null,"Armstrong Thomas"]
[null,null,"Titolo",null,"Awakening genius in the classroom [[electronic resource] /] / Thomas Armstrong"]
[null,null,"Pubbl/distr/stampa",null,"Alexandria, Va., : Association for Supervision and Curriculum Development, c1998"]
[null,null,"ISBN",null,"1-4166-1612-8"]
[{"$nulls":4},"0-87120-302-2"]
[{"$nulls":4},"1-4166-0398-0"]
[{"$nulls":4},"9786610933389"]
[{"$nulls":4},"1-280-93338-0"]
[null,null,"Descrizione fisica",null,"ix, 81 p"]
[null,null,"Disciplina",null,"370.15/23"]
[null,null,"Soggetti",null,"Learning, Psychology of"]
[{"$nulls":4},"Motivation in education"]
[{"$nulls":4},"Motivation (Psychology) in children"]
[{"$nulls":4},"Cognitive styles"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Nota di bibliografia","Includes bibliographical references (p. 72-80)."]
[null,null,"Nota di contenuto",null,"Every student is a genius. The 12 qualities of genius : curiosity, playfulness, imagination, creativity, wonder, wisdom, inventiveness, vitality, sensitivity, flexibility, humor, joy. Theoretical foundations : neurological basis, evolutionary basis, biographical basis, phenomenological basis. For further study -- The genius shuts down. The role of the home : emotional dysfunction, poverty, fast-track, lifestyles, rigid ideologies. The role of the school : testing and grading, labeling and tracking, textbooks and worksheet learning, tedium. The role of the popular media : stereotypical images, insipid language, mediocre content. For further study -- How to awaken genius in the classroom. Reawaken the genius in yourself. Provide simple genius experiences. Create a genial climate in the classroom : freedom to choose, open-ended exploration, freedom from judgment, honoring every student's experience, believing in every student's genius. Know that genius is expressed in many ways. For further study."]
[null,null,null,"Sommario/riassunto","\"Every student is a genius,\" declares author Thomas Armstrong, and an educator's most important job is to discover and nurture the \"genius qualities\" that all students were born with but that may no longer be "]
[{"$nulls":4},"obvious. Urging readers to look beyond traditional understandings of what constitutes genius, Armstrong describes 12 such qualities: curiosity, playfulness, imagination, creativity, wonder, wisdom, inventiveness, vitality, sensitivity, flexibility, humor, and joy. He cites research in various fields that supports this broader understanding of genius and explains how influences in the home, the popular media, and the school itself \"shut down\" the genius in students. Combining thoughtful insights and practical information, Armstrong offers guiding principles to help educators awaken genius in the classroom--beginning with awakening the genius in themselves. Readers will find dozens of suggested activities and helpful resources to provide \"genius experiences\" and create a \"genial climate\" in the classroom. In addition, suggestions for further study at the end of each section provide starting points for personal and professional reflection and growth.As it celebrates the potential brainpower waiting to be unlocked in classrooms everywhere, Awakening Genius in the Classroom inspires educators to look at their students from a different perspective and to reinvigorate their teaching with a new sense of excitement and possibility. The result, Armstrong concludes, could extend far beyond the classroom and transform not only our schools, but the entire world."]