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[null,"1.","Record Nr.",null,"UNINA9910782498103321"]
[null,null,"Autore",null,"Wu Zhijun <1956->"]
[null,null,"Titolo",null,"Lecture notes on computational structural biology [[electronic resource] /] / Zhijun Wu"]
[null,null,"Pubbl/distr/stampa",null,"Singapore ; ; Hackensack, NJ, : World Scientific, c2008"]
[null,null,"ISBN",null,"1-281-96817-X"]
[{"$nulls":4},"9786611968175"]
[{"$nulls":4},"981-281-478-7"]
[null,null,"Descrizione fisica",null,"1 online resource (244 p.)"]
[null,null,"Disciplina",null,"572.80285"]
[null,null,"Soggetti",null,"Computational biology"]
[{"$nulls":4},"Structural bioinformatics"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"1. Introduction. 1.1. Protein structure. 1.2. Structure determination. 1.3. Dynamics simulation. 1.4. The myth of protein folding -- 2. X-ray crystallography computing. 2.1. The phase problem. 2.2. Least squares solutions. 2.3. Entropy maximization. 2.4. Indirect methods -- 3. NMR structure determination. 3.1. Nuclear magnetic resonance. 3.2. Distance geometry. 3.3. Distance-based modeling. 3.4. Structural analysis -- 4. Potential energy minimization. 4.1. Potential energy function. 4.2. Local optimization. 4.3. Global optimization. 4.4. Energy transformation -- 5. Molecular dynamics simulation. 5.1. Equations of motion. 5.2. Initial-value problem. 5.3. Boundary-value problem. 5.4. Normal mode analysis -- 6. Knowledge-based protein modeling. 6.1. Sequence/structural alignment. 6.2. Fold recognition/inverse folding. 6.3. Knowledge-based structural refinement. 6.4. Structural computing and beyond."]
[null,null,null,"Sommario/riassunto","While the field of computational structural biology or structural bioinformatics is rapidly developing, there are few books with a relatively complete coverage of such diverse research subjects studied in the field as X-ray crystallography computing, NMR structure determination, potential energy minimization, dynamics simulation, and knowledge-based modeling. This book helps fill the gap by providing such a survey on all the related subjects. Comprising a collection of lecture notes for a computational structural biology course for the Program on Bioinformatics and Computational Biology at Iow"]