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[null,"1.","Record Nr.",null,"UNINA9910136280003321"]
[null,null,"Autore",null,"Feng C Zhou"]
[null,null,"Titolo",null,"Genetics and epigenetics of fetal alcohol spectrum disorders / / edited by: Feng C. Zhou and Stephen Mason"]
[null,null,"Pubbl/distr/stampa",null,"Frontiers Media SA, 2015"]
[{"$nulls":4},"Switzerland : , : Frontiers Media SA, , 2015"]
[null,null,"ISBN",null,"9782889195732 (ebook)"]
[null,null,"Descrizione fisica",null,"1 online resource (114 pages) : illustrations"]
[null,null,"Collana",null,"Frontiers Research Topics"]
[null,null,"Soggetti",null,"Pregnant women - Alcohol use"]
[{"$nulls":4},"Fetal alcohol spectrum disorders - Evaluation"]
[{"$nulls":4},"Children of prenatal alcohol abuse"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Bibliographic Level Mode of Issuance: Monograph"]
[null,null,null,"Nota di bibliografia","Includes bibliographical references."]
[null,null,null,"Sommario/riassunto","Women drinking during pregnancy can result in Fetal Alcohol Spectrum Disorder (FASD), which features neurodevelopmental deficit, facial dysmorphology, growth retardation, and learning disability. Research suggests the human brain is precisely shaped through an intrinsic, genetic-cellular expression that is orchestrated further upstream by an epigenetic program. This program can be influenced by environmental inputs such as alcohol. Current research suggests the genetic and epigenetics of FASD are becoming intertwined and inseparable. Now is the time for investigators to combine genetic, genomic and epigenetic alcohol research into an accessible, online platform discussion. Genetic analyses inform gene sets vulnerable to alcohol exposure during early neurulation. Prenatal alcohol exposure alters expression of gene subsets, including genes involved in neural specification, hematopoiesis, methylation, chromatin remodeling, histone variants, eye and heart development. Recently, quantitative map locusing (QTLs) that mediate alcohol-induced phenotype were identified between two mouse strains. Another question is -- besides amount, dose, and stage of alcohol exposure, why only 5% of women drinking have a newborn with FAS? Studies are also ongoing to answer this question by characterizing genome-wide expression, allele-specific expression (ASE), gene polymorphisms (SNPs) and maternal genetic factors that influence alcohol vulnerability. Alcohol exposure during pregnancy, "]
[{"$nulls":4},"which can lead to FASD, has been used as a model to resolve the epigenetic pathway between environment and phenotype. Epigenetics modifies genetic outputs through alteration of 3D chromatin structure and accessibility of transcriptional machinery. Several laboratories have reported altered epigenetics, including DNA methylation and histone modification, in multiple models of FASD. During development DNA methylation is dynamic, yet orchestrated as methylation progresses in a precise spatiotemporal manner during neurulation and coincides with neural differentiation. Alcohol can directly influence epigenetics through alterations of the methionine pathway and subsequent DNA or histone methylation/acetylation. Alcohol also alters noncoding RNA including miRNA and transposable elements (TEs). Evidence suggests that miRNA expression may mediate ethanol teratology, and TEs may be affected by alcohol through altering DNA methylation at LTR. In this manner epigenetic and genetics of FASD are becoming mechanistically intertwined. Can alcohol-induced epigenomic alterations be passed through generations? Early epidemiological studies revealed infants with FASD-like features in the absence of maternal alcohol, where the fathers were alcoholics. Novel mechanisms for alcohol-induced phenotypes include altered sperm DNA methylation, hypomethylated paternal allele and heritable epimutation. These studies predict heritability of alcohol-induced epigenetic abnormalities and gene functionality across generations."]
[null,"2.","Record Nr.",null,"UNINA9910782497403321"]
[null,null,"Autore",null,"Johnstone William"]
[null,null,"Titolo",null,"1 and 2 Chronicles . Volume 1 1 Chronicles 1-2 Chronicles 9 : Israel's place among the nations [[electronic resource] /] / William Johnstone"]
[null,null,"Pubbl/distr/stampa",null,"Sheffield, : Sheffield Academic Press, c1997"]
[null,null,"ISBN",null,"1-281-81448-2"]
[{"$nulls":4},"9786611814489"]
[{"$nulls":4},"0-8264-4130-0"]
[null,null,"Descrizione fisica",null,"1 online resource (418 p.)"]
[null,null,"Collana",null,"Journal for the study of the Old Testament. Supplement series ; ; 253"]
[null,null,"Disciplina",null,"222"]
[{"$nulls":4},"222.606"]
[{"$nulls":4},"222/.606"]
[null,null,"Soggetti",null,"Narration in the Bible"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and indexes."]
[null,null,"Nota di contenuto",null,"Contents; Abbreviations; Introduction; 1 Chronicles 1: Israel's Place within the Human Family; 1 Chronicles 2.1-2: Preview of 1 Chronicles 2-8; 1 Chronicles 2.3-4.23: Judah and the House of David; 1 Chronicles 4.24-5.2: Simeon; 1 Chronicles 5.3-26: The East Bank Tribes: Reuben, Gad and Half-Manasseh; 1 Chronicles 6: Levi; 1 Chronicles 7-9: The West Bank Tribes and Jerusalem; 1 Chronicles 7.1-5: Issachar; 1 Chronicles 7.6-13: Benjamin (1) with Naphtali; 1 Chronicles 7.14-19: Manasseh; 1 Chronicles 7.20-29: Ephraim; 1 Chronicles 7.30-40: Asher; 1 Chronicles 8: Benjamin (2)"]
[{"$nulls":4},"1 Chronicles 9.1-34: The Population of Jerusalem1 Chronicles 9.35-10.14: The Reign of Saul; 1 Chronicles 11.1-29.30: David: Enabler of Israel's Destiny among the Nations of the World?; 1 Chronicles 11.1-9: David, king of 'All Israel';  Jerusalem, City of David; 1 Chronicles 11.10-12.40: The Roll of Warriors who Joined Forces with King David; 1 Chronicles 13: David's Initiative to Fetch the Ark of God is Cut Short; 1 Chronicles 14.1-16.43: The Installation of the Ark in Jerusalem; 1 Chronicles 17: David's Proposal to Build a Temple is Rejected"]
[{"$nulls":4},"1 Chronicles 18-20: The Fulfilment of the LORD's Promise to Subdue David's Enemies1 Chronicles 21.1-22.4: The Census: Pivotal Event of David's Reign; 1 Chronicles 22.5-19: David Commissions Solomon to Build the Temple; 1 Chronicles 23-27: The Personnel of Temple and Community; 1 Chronicles 28-29: David's Reign Fulfilled; 2 Chronicles "]
[{"$nulls":4},"1-9: The Reign of Solomon; 2 Chronicles 1.1-13: The Sacral Assembly Is Convened at the Tabernacle at Gibeon. The Theological Basis of Solomon's Rule; 2 Chronicles 2.3-16: Solomon's Correspondence with Huram of Tyre"]
[{"$nulls":4},"2 Chronicles 2.17-5.1: Solomon Builds the Temple2 Chronicles 5.2-7.22: The Dedication of the Temple; 2 Chronicles 8.1-9.31: The Universal Recognition of Solomon's Reign; Bibliography; Index of References; Index of Selected Key Terms"]
[null,null,null,"Sommario/riassunto","This two-part commentary argues that Chronicles, placed as it is among the 'historical books' in the traditional Old Testament of the Christian church, is much misunderstood. Restored to its proper position as the final book in the canon as arranged in the order of the Hebrew Bible, it is rather to be understood as a work of theology essentially directed towards the future. The Chronicler begins his work with the problem facing the whole human race in Adam-the forfeiture of the ideal of perfect oneness with God's purpose. He explores the possibility of the restoration of that ideal through Isr"]