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[null,"1.","Record Nr.",null,"UNINA9910502627903321"]
[null,null,"Titolo",null,"Suprachoroidal space interventions / / Shohista Saidkasimova, Thomas H. Williamson, editors"]
[null,null,"Pubbl/distr/stampa",null,"Cham, Switzerland : , : Springer, , [2021]"]
[{"$nulls":4},"©2021"]
[null,null,"ISBN",null,"3-030-76853-8"]
[null,null,"Descrizione fisica",null,"1 online resource (166 pages)"]
[null,null,"Disciplina",null,"617.72"]
[null,null,"Soggetti",null,"Choroid - Surgery"]
[{"$nulls":4},"Choroid - Diseases"]
[{"$nulls":4},"Coroide"]
[{"$nulls":4},"Oftalmopaties"]
[{"$nulls":4},"Cirurgia ocular"]
[{"$nulls":4},"Llibres electrònics"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,"Nota di contenuto",null,"Intro -- Contents -- Anatomy and Physiology of the Suprachoroidal Space -- Introduction -- Embryogenesis -- Sclera -- Choroid -- Suprachoroid -- Vessels in the Suprachoroid -- Nerves in the Suprachoroid -- Supraciliary Space -- Topographic Anatomy for Interventive Procedures -- Suprachoroidal Space and Uveal Effusion -- Suprachoroid in High Myopia -- Suprachoroidal Changes with Age -- Physiology -- Uveoscleral Outflow -- Fluid Dynamics in the Eye and the Suprachoroidal Space -- Summary -- References -- Imaging the Suprachoroidal Space -- Introduction -- Methods of Imaging the Suprachoroidal Space -- Contact B-Scan Ultrasonography -- Optical Coherence Tomography -- Evaluation of the Choroid and Ambiguities Introduced by the Suprachoroidea -- Evaluating the Suprachoroidal Space -- Summary -- References -- Suprachoroidal Haemorrhage -- Introduction -- Pathogenesis -- Dynamics of Suprachoroidal Haemorrhage -- Phase 1: Ciliary Artery Rupture -- Phase 2: Dissemination of Blood into the Extravascular Space -- Bruch's Membrane and Sclera -- Scattered Focal Adhesions Between Eye Wall Layers -- Linear Adhesions at Ora Serrata -- Clinical Presentation -- Investigation: Ultrasound -- Management of SCH -- References -- Choroidal Detachment -- Introduction -- Pathophysiology -- Clinical "]
[{"$nulls":4},"Findings -- Differential Diagnoses -- Causes -- Inflammatory Causes of Serous Choroidal Detachment -- Hydrostatic Causes of Serous Choroidal Detachment -- Uveal Effusion Syndrome (UES) -- Management -- References -- Suprachoroidal Space and Glaucoma -- Introduction -- Pharmacological Manipulation of the Uveoscleral Outflow -- Prostaglandin Analogues -- Surgical Exploration of Suprachoroidal Space in Glaucoma -- Cyclodialysis Cleft -- Cyclodialysis as Surgical Treatment -- Glaucoma Implants for Suprachoroidal Space -- SOLX Gold Microshunt -- Cypass Suprachoroidal Microshunt."]
[{"$nulls":4},"Future Suprachoroidal Glaucoma Devices -- iStent Supra -- MINIject -- Summary -- References -- Suprachoroidal Buckling for Peripheral Retinal Breaks -- Introduction -- Suprachoroidal Hydrogel Buckle -- Combining the Best of Both Worlds -- The Rationale of Suprachoroidal Hydrogel Buckle -- Historical Development -- Working in the Suprachoroidal Space -- Milestones in Technical Refinement -- Surgical Technique -- Two Surgical Approaches to Suprachoroidal Buckling Surgery -- Suprachoroidal Hydrogel Buckle Combined with Vitrectomy -- Suprachoroidal Hydrogel Buckle as a Stand-Alone Procedure -- Catheter or Cannula? -- Catheter -- Olive Tip Cannula -- Laser or Cryo Retinopexy -- Biocompatibility and Resorption Time of the Different Hydrogels -- Complications and the Learning Curve -- Conclusion -- References -- Suprachoroidal Buckling for Myopic Macular Holes -- Introduction -- Surgical Management of MTM -- Suprachoroidal Surgery for MTM -- Pearls and Pitfalls of Suprachoroidal Buckle Surgery -- Conclusion -- References -- Suprachoroidal Drug Delivery -- Introduction -- Fundamentals of Suprachoroidal Drug Delivery -- Anatomical Considerations in the SC Drug Delivery -- Histological Changes After the Injection -- Pharmacodynamics and Pharmacokinetics -- Drug Delivery Technique -- Safety and Complications -- Clinical Application -- Age Related Macular Degeneration (AMD) -- Retinal Vein Occlusion (RVO) -- Uveitis -- Diabetic Macular Oedema (DMO) -- Melanoma -- Summary -- References -- Suprachoroidal Delivery of Subretinal Gene and Cell Therapy -- Introduction -- Current Landscape of Retinal Therapies -- Gene Versus Cell Therapy -- Gene Therapy -- Cell Therapy -- Approaches for Retinal Therapy -- Intravitreal Delivery -- Subretinal Delivery -- Suprachoroidal Delivery -- Methods to Access the Suprachoroidal Space -- Standard Hypodermic Needle."]
[{"$nulls":4},"Transscleral Microneedle -- Tunnelled Microcatheter -- Conclusion -- References -- The Development of a Suprachoroidal Retinal Prosthesis -- Conclusion -- References."]
[null,"2.","Record Nr.",null,"UNINA9910703006203321"]
[null,null,"Titolo",null,"Sudan [[electronic resource] ] : a critical moment for the C.P.A., Darfur, and the region : hearing before the Committee on Foreign Relations, United States Senate, One Hundred Eleventh Congress, second session, May 12, 2010"]
[null,null,"Pubbl/distr/stampa",null,"Washington : , : U.S. G.P.O., , 2010"]
[null,null,"Descrizione fisica",null,"1 online resource (iii, 41 pages)"]
[null,null,"Collana",null,"S. hrg. ; ; 111-749"]
[null,null,"Soggetti",null,"Peace-building - Sudan"]
[{"$nulls":4},"Referendum - South Sudan"]
[{"$nulls":4},"Self-determination, National - South Sudan"]
[{"$nulls":4},"Sudan History Civil War, 1983-2005 Peace"]
[{"$nulls":4},"Sudan History Darfur Conflict, 2003- Peace"]
[{"$nulls":4},"Sudan Politics and government 1985-"]
[{"$nulls":4},"South Sudan Politics and government 21st century"]
[{"$nulls":4},"United States Foreign relations Sudan"]
[{"$nulls":4},"Sudan Foreign relations United States"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Title from PDF title screen (viewed on Jan. 14, 2011)."]
[{"$nulls":4},"Paper version available for sale by the Supt. of Docs., U.S. G.P.O."]
[null,"3.","Record Nr.",null,"UNINA9910782094903321"]
[null,null,"Titolo",null,"The cancer degradome [[electronic resource] ] : proteases and cancer biology / / edited by Dylan Edwards ... [et al.]"]
[null,null,"Pubbl/distr/stampa",null,"New York, : Springer, c2008"]
[null,null,"ISBN",null,"1-281-79189-X"]
[{"$nulls":4},"9786611791896"]
[{"$nulls":4},"0-387-69057-3"]
[null,null,"Edizione",null,"[1st ed. 2008.]"]
[null,null,"Descrizione fisica",null,"1 online resource (946 p.)"]
[null,null,"Disciplina",null,"616.994"]
[null,null,"Soggetti",null,"Cancer - Molecular aspects"]
[{"$nulls":4},"Proteolytic enzymes"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"The Degradome and Its Analysis -- Protease Genomics and the Cancer Degradome -- The CLIP-CHIP™: A Focused Oligonucleotide Microarray Platform for Transcriptome Analysis of the Complete Human and Murine Cancer Degradomes -- The Hu/Mu ProtIn Chip: A Custom Dual-Species Oligonucleotide Microarray for Profiling Degradome Gene Expression in Tumors and Their Microenvironment -- Quantitative Real-Time PCR Analysis of Degradome Gene Expression -- Identification of Protease Substrates by Mass Spectrometry Approaches-1 -- Identification of Protease Substrates by Mass Spectrometry Approaches-2 -- Activity-Based Imaging and Biochemical Profiling Tools for Analysis of the Cancer Degradome -- Images of Cleavage: Tumor Proteases in Action -- Insights into Protease Function -- Proteolytic Pathways: Intersecting Cascades in Cancer Development -- Physiological Functions of Plasminogen Activation: Effects of Gene Deficiencies in Humans and Mice -- The Plasminogen Activation System in Tissue Remodeling and Cancer Invasion -- The Urokinase Plasminogen Activator Receptor as a Target for Cancer Therapy -- The Endocytic Collagen Receptor, uPARAP/Endo180, in Cancer Invasion and Tissue Remodeling -- Physiological and Pathological Functions of Type II Transmembrane Serine Proteases: Lessons from Transgenic Mouse Models and Human Disease-Associated Mutations -- Roles of Cysteine Proteases in Tumor Progression: Analysis of Cysteine Cathepsin Knockout Mice in Cancer Models -- In Vitro and In Vivo Models of "]
[{"$nulls":4},"Angiogenesis to Dissect MMP Functions -- The Surface Transplantation Model to Study the Tumor–Host Interface -- Unravelling the Roles of Proteinases in Cell Migration In Vitro and In Vivo -- New Insights into MMP function in Adipogenesis -- TIMPs: Extracellular Modifiers in Cancer Development -- The Interface Between Proteolysis and Cell Signalling -- Invadopodia: Interface for Invasion -- uPAR and Proteases in Mobilization of Hematopoietic Stem Cells -- The Urokinase Receptor and Integrins Constitute a Cell Migration Signalosome -- Measuring uPAR Dynamics in Live Cells -- Janus-Faced Effects of Broad-Spectrum and Specific MMP Inhibition on Metastasis -- Cytokine Substrates: MMP Regulation of Inflammatory Signaling Molecules -- Matrix Metalloproteinases as Key Regulators of Tumor–Bone Interaction -- The Degradome as Source of Cancer Diagnostic and Markers -- The Plasminogen Activation System as a Source of Prognostic Markers in Cancer -- Cysteine Cathepsins and Cystatins as Cancer Biomarkers -- Novel Degradome Markers in Breast Cancer -- Meta-Analysis of Gene Expression Microarray Data: Degradome Genes in Healthy and Cancer Tissues -- Degradome Gene Polymorphisms -- TIMP-1 as a Prognostic Marker in Colorectal Cancer -- Novel Therapeutic Strategies -- Structure and Inhibition of the Urokinase-Type Plasminogen Activator Receptor -- Engineered Antagonists of uPA and PAI-1 -- MMP Inhibitor Clinical Trials – The Past, Present, and Future -- Tailoring TIMPs for Selective Metalloproteinase Inhibition -- Third-Generation MMP Inhibitors: Recent Advances in the Development of Highly Selective Inhibitors -- Protease-Activated Delivery and Imaging Systems -- Development of Tumour-Selective and Endoprotease-Activated Anticancer Therapeutics -- Targeting Degradome Genes via Engineered Viral Vectors."]
[null,null,null,"Sommario/riassunto","Proteases that act in the extracellular environment have been historically associated with tumorigenesis and metastasis by virtue of their ability to carry out \"path-clearing\" for cancer cells. In the past few years it has become clear that they also shape the pericellular signaling environment, with profound consequences for cell fate and phenotype in both normal development and disease states. The repertoire of proteases that cells and tissues coordinately regulate in order to modulate their local environment is the DEGRADOME – which in humans is represented by at least 569 proteases in five catalytic classes. \"The Cancer Degradome: Proteases in Cancer Biology\" , edited by Dylan Edwards, Francesco Blasi, Gunilla-Høyer-Hansen and Bonnie Sloane, covers recent knowledge of the composition of the Degradome, how it can be studied using modern approaches such as transcriptomics and mass spectrometry; how protease activity can be imaged both in vitro and in vivo; how gene knockout mice have improved our knowledge of the roles of proteases in cancer; the links that have emerged between proteolysis and cell signaling; how the Degradome can be a useful source of diagnostic and prognostic markers; and finally new approaches to target proteolysis for therapy."]