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[null,"1.","Record Nr.",null,"UNINA9910144011403321"]
[null,null,"Titolo",null,"Oligonucleotides as therapeutic agents [[electronic resource] /] / [editors, Derek J. Chadwick (Organizer) and Gail Cardew]"]
[null,null,"Pubbl/distr/stampa",null,"Chichester ; ; New York, : Wiley, 1997"]
[null,null,"ISBN",null,"1-282-34805-1"]
[{"$nulls":4},"9786612348051"]
[{"$nulls":4},"0-470-51539-2"]
[{"$nulls":4},"0-470-51540-6"]
[null,null,"Descrizione fisica",null,"1 online resource (262 p.)"]
[null,null,"Collana",null,"Ciba Foundation symposium ; ; 209"]
[null,null,"Disciplina",null,"615"]
[{"$nulls":4},"615.31"]
[null,null,"Soggetti",null,"Oligonucleotides - Therapeutic use"]
[{"$nulls":4},"Antisense nucleic acids - Therapeutic use"]
[{"$nulls":4},"Electronic books."]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Proceedings of the Symposium on Oligonucleotides as Therapeutic Agents, held at Ciba Foundation on 7-9 January 1997."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and indexes."]
[null,null,"Nota di contenuto",null,"OLIGONUCLEOTIDES AS THERAPEUTIC AGENTS; Contents; Participants; Introduction; Oligoncleotide analogues: an overview; Phosphorothioate oligodeox ynucleotides: large-scale synthesis and analysis, impurity characterization, and the effects of phosphorus stereochemistry; Discovering antisense reagents by hybridization of RNA to oligonucleotide arrays; Pharrnacokinetics of oligonucleotides in cell culture; Pharrnacokinetics of oligonucleotides; Controversies in the cellular pharmacology of oligodeox ynucleotides; Sequence-specific control of gene expression by antigene and clamp oligonucleotides"]
[{"$nulls":4},"First- and second-generation antisense oligonucleotide inhibitors targeted against human c-raf kinaseDifferential oligonucleotide activity in cell culture versus mouse models; Structure-activity relationships in cell culture; Progress in antisense therapeutics discovery and development; Oligonucleotide therapeutics for human leukemia; Therapeutic applications of catalytic antisense RNAs (ribozymes); Exogenous application of riboaymes for inhibiting gene expression; Efficient process technologies for the preparation of oligonucleotides"]
[{"$nulls":4},"In vivo production of oligodeoxyribonucleotides of specific sequences: application to antisense DNASummary; Index of contributors; Subject "]
[{"$nulls":4},"index"]
[null,null,null,"Sommario/riassunto","The use of oligonucleotides as therapeutic agents rests upon their ability to interfere, in a sequence-specific manner, with the fundamental machinery of protein synthesis either by binding to the mRNAs transcribed from a gene or by binding directly to a target gene. This approach can be used not only for inhibition of the synthesis of host proteins but also of those required by invading pathogens. Potential therapeutic applications are enormous, ranging over hypertension, cardiovascular disease, autoimmune disease, vital and other parasitic infections (especially HIV), and cancer. This book d"]
[null,"2.","Record Nr.",null,"UNISALENTO991000062369707536"]
[null,null,"Autore",null,"Rassegna pisana [di] arti figurative <6. ; 1966 ; Pisa>"]
[null,null,"Titolo",null,"6. [sesta] Rassegna [di] arti figurative e artigianato artistico nella provincia di Pisa : catalogo / a cura di Ranieri Varese"]
[null,null,"Pubbl/distr/stampa",null,"Pisa : V. Lischi, [1966]"]
[null,null,"Descrizione fisica",null,"143 p. : ill. ; 16x16 cm."]
[null,null,"Soggetti",null,"Arte italiana - Esposizioni"]
[{"$nulls":4},"Artigianato - Italia - Esposizioni"]
[null,null,"Lingua di pubblicazione",null,"Italiano"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","In testa al front.: Amministrazione provinciale di Pisa."]
[null,"3.","Record Nr.",null,"UNINA9910777590503321"]
[null,null,"Autore",null,"Boszhardt Robert F"]
[null,null,"Titolo",null,"A projectile point guide for the Upper Mississippi River Valley [[electronic resource] /] / Robert F. Boszhardt"]
[null,null,"Pubbl/distr/stampa",null,"Iowa City, : University of Iowa Press, c2003"]
[null,null,"ISBN",null,"1-58729-441-9"]
[null,null,"Descrizione fisica",null,"1 online resource (105 p.)"]
[null,null,"Collana",null,"A Bur Oak guide"]
[null,null,"Disciplina",null,"623.4/41"]
[{"$nulls":4},"623.441"]
[null,null,"Soggetti",null,"Indians of North America - Implements - Mississippi River Valley"]
[{"$nulls":4},"Indians of North America - Mississippi River Valley - Antiquities"]
[{"$nulls":4},"Projectile points - Mississippi River Valley"]
[{"$nulls":4},"Mississippi River Valley Antiquities Guidebooks"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references (p. 79-87) and index."]
[null,null,"Nota di contenuto",null,"Acknowledgments; Introduction; Site Recording Form; Point Features and Terminology; Early Paleo Fluted spear points; Clovis; Folsom/Midland; Eastern Fluted (Gainey); Late Paleo Lanceolate points; Plainview; Agate Basin; Hell Gap; Frederick/Allen/Browns Valley; Eden/Scottsbluff; Dalton/Quad; Hi-Lo/Price Stemmed/Chesro; Early Archaic Stemmed and Corner-notched Points; Hardin Barbed; Thebes; St. Charles; Kessell Side-Notched; Kirk Corner-Notched; Middle Archaic Stemmed and side-notched Points; Matanzas; Raddatz Side-Notched/Osceola; Late Archaic Stemmed and corner-notched Points"]
[{"$nulls":4},"Preston Corner-NotchedDurst Stemmed; Early Woodland Stemmed Points; Kramer; Waubesa Contracting Stem/Dickson Broad Blade; Middle Woodland Broad Corner-notched Points; Snyders Corner-Notched/Manker Corner-Notched; Steuben Expanded Stemmed/McCoy Corner-Notched/Monona Stemmed; Late Prehistoric Woodland and Oneota arrowheads; Honey Creek Corner-Notched; Cahokia/Grant Side-Notched; Madison Triangular; Bibliography; Index"]
[null,null,null,"Sommario/riassunto","The most common relics of the 12,000-year occupancy of the Upper Mississippi River Valley may be the chipped stone projectile points that Native Americans fastened to the ends of their spears, darts, and arrow shafts. This useful guide provides a key to identifying the various styles of points found along the Upper Mississippi River in the Driftless region stretching roughly from Dubuque, Iowa, to Red Wing, Minnesota, but "]
[{"$nulls":4},"framed within a somewhat larger area extending from the Rock Island Rapids at the modern Moline-Rock Island area to the Falls of St. Anthony at Minneapolis-St. Paul."]