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[null,null,"Titolo",null,"Cellular entry of binary and pore-forming bacterial toxins / / edited by Alexey S. Ladokhin"]
[null,null,"Pubbl/distr/stampa",null,"Basel, Switzerland : , : MDPI, , [2018]"]
[{"$nulls":4},"©2018"]
[null,null,"ISBN",null,"3-03842-703-9"]
[null,null,"Descrizione fisica",null,"1 online resource (128 pages) : illustrations"]
[null,null,"Disciplina",null,"615.95299"]
[null,null,"Soggetti",null,"Bacterial toxins"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Nota di bibliografia","Includes bibliographical references."]
[null,null,"Nota di contenuto",null,"About the Special Issue Editor  v -- Alexey S. Ladokhin Cellular Entry of Binary and Pore-Forming Bacterial Toxins doi: 10.3390/toxins10010011  1 -- Masaya Takehara, Teruhisa Takagishi, Soshi Seike, Masataka Oda, Yoshihiko Sakaguchi, Junzo Hisatsune, Sadayuki Ochi, Keiko Kobayashi and Masahiro Nagahama Cellular Entry of Clostridium perfringens Iota-Toxin and Clostridium botulinum C2 Toxin doi: 10.3390/toxins9080247  3 -- Alfredo J. Guerra and Vern B. Carruthers Structural Features of Apicomplexan Pore-Forming Proteins and Their Roles in Parasite Cell Traversal and Egress doi: 10.3390/toxins9090265  12 -- Sergey N. Savinov and Alejandro P. Heuck Interaction of Cholesterol with Perfringolysin O: What Have We Learned from Functional Analysis? doi: 10.3390/toxins9120381  27 -- Alexandra J. Machen, Narahari Akkaladevi, Caleb Trecazzi, Pierce T. ONeil, Srayanta Mukherjee, Yifei Qi, Rebecca Dillard, Wonpil Im, Edward P. Gogol, Tommi A. White and Mark T. Fisher Asymmetric Cryo-EM Structure of Anthrax Toxin Protective Antigen Pore with Lethal Factor N-Terminal Domain doi: 10.3390/toxins9100298  44 -- Alexey S. Ladokhin, Mauricio Vargas-Uribe, Mykola V. Rodnin, Chiranjib Ghatak and Onkar Sharma Cellular Entry of the Diphtheria Toxin Does Not Require the Formation of the Open-Channel State by Its Translocation Domain doi: 10.3390/toxins9100299  60 -- Primoz Knap, Toma Tebaldi, Francesca Di Leva, Marta Biagioli, Mauro Dalla Serra and Gabriella Viero The Unexpected Tuners: Are LncRNAs Regulating Host Translation during Infections? doi: 10.3390/toxins9110357  72 -- Franziska Tausch, Richard Dietrich, Kristina Schauer, Robert Janowski, Dierk Niessing, Erwin Mrtlbauer and Nadja Jessberger Evidence for "]
[{"$nulls":4},"Complex Formation of the Bacillus cereus Haemolysin BL Components in Solution doi: 10.3390/toxins9090288  82 -- Leopoldo Palma, David J. Scott, Gemma Harris, Salah-Ud Din, Thomas L. Williams, Oliver J. Roberts, Mark T. Young, Primitivo Caballero and Colin Berry The Vip3Ag4 Insecticidal Protoxin from Bacillus thuringiensis Adopts A Tetrameric Configuration That Is Maintained on Proteolysis doi: 10.3390/toxins9050165  100 -- Madhu Puri, Luigi La Pietra, Mobarak Abu Mraheil, Rudolf Lucas, Trinad Chakraborty and Helena Pillich Listeriolysin O Regulates the Expression of Optineurin, an Autophagy Adaptor That Inhibits the Growth of Listeria monocytogenes doi: 10.3390/toxins9090273  111."]
[null,null,null,"Sommario/riassunto","Bridging cellular membranes is a key step in the pathogenic action of both binary and pore-forming bacterial toxins. The former use their translocation domains, containing various structural motifs, to ensure efficient delivery of the toxic component into the host cell, while the latter act on the cellular membrane itself. In either case, the integrity of the membrane is compromised via targeted protein-lipid and protein-protein interactions triggered by specific signals, such as proteolytic cleavage or endosomal acidification. This Special Issue presents recent advances in characterizing functional, structural and thermodynamic aspects of the conformational switching and membrane interactions involved in the cellular entry of bacterial protein toxins. Deciphering the physicochemical principles underlying these processes is also a prerequisite for the use of protein engineering to develop toxin-based molecular vehicles capable of targeted delivery of therapeutic agents to tumors and other diseased tissues."]