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[null,"1.","Record Nr.",null,"UNINA9910557306103321"]
[null,null,"Autore",null,"Wan Edwin"]
[null,null,"Titolo",null,"Cellular and Molecular Mechanisms in Pathogenesis of Multiple Sclerosis"]
[null,null,"Pubbl/distr/stampa",null,"Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020"]
[null,null,"Descrizione fisica",null,"1 online resource (182 p.)"]
[null,null,"Soggetti",null,"Medicine and Nursing"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Sommario/riassunto","Multiple sclerosis (MS) is one of the most common neurological disorders in young adults. The etiology of MS is not known, but it is generally accepted that it is autoimmune in nature. Our knowledge of the pathogenesis of MS has increased tremendously in the past decade through clinical studies and the use of experimental autoimmune encephalomyelitis (EAE), a model that has been widely used for MS research. Major advances in the field, such as understanding the roles of pathogenic Th17 cells, myeloid cells, and B cells in MS/EAE, as well as cytokine and chemokine signaling that controls neuroinflammation, have led to the development of potential and clinically approved disease-modifying agents (DMAs). There are many aspects related to the initiation, relapse and remission, and progression of MS that are yet to be elucidated. For instance, what are the genetic and environmental risk factors that promote the initiation of MS, and how do these factors impact the immune system? What factors drive the progression of MS, and what are the roles of peripheral immune cells in disease progression? How do the CNS-infiltrated immune cells interact with the CNS-resident glial cells when the disease progresses? What is the role of microbiome in MS? Can we develop animal models that better represent subcategories of MS? Understanding the cellular and molecular mechanisms that govern the pathogenesis of MS will help to develop novel and more specific therapeutic strategies that will ultimately improve clinical outcomes of the treatments. This Special Issue of Cells has published original research articles, a retrospective clinical report, and review articles that investigate the cellular and "]
[{"$nulls":4},"molecular basis of MS."]
[null,"2.","Record Nr.",null,"UNINA9910746099603321"]
[null,null,"Autore",null,"Haddington Pentti"]
[null,null,"Titolo",null,"Complexity of Interaction : Studies in Multimodal Conversation Analysis / / edited by Pentti Haddington, Tiina Eilittä, Antti Kamunen, Laura Kohonen-Aho, Iira Rautiainen, Anna Vatanen"]
[null,null,"Pubbl/distr/stampa",null,"Cham : , : Springer Nature Switzerland : , : Imprint : Palgrave Macmillan, , 2023"]
[null,null,"ISBN",null,"9783031307270"]
[{"$nulls":4},"3031307275"]
[null,null,"Edizione",null,"[1st ed. 2023.]"]
[null,null,"Descrizione fisica",null,"1 online resource (514 pages)"]
[null,null,"Disciplina",null,"302"]
[null,null,"Soggetti",null,"Sociolinguistics"]
[{"$nulls":4},"Ethnology"]
[{"$nulls":4},"Interpersonal communication"]
[{"$nulls":4},"Ethnography"]
[{"$nulls":4},"Communication Psychology"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,"Nota di contenuto",null,"Chapter 1. On the complexities of interaction: An introduction (Tiina Eilittä, Pentti Haddington, Antti Kamunen, Laura Kohonen-Aho, Iira Rautiainen and Anna Vatanen) -- Part I: Complexity that resides in multiactivity multisensoriality -- Chapter 2. Tasting vs. eating: The methodic and situated differentiation of embodied multisensorial activities in social interaction (Lorenza Mondada) -- Chapter 3. Metagaming and multiactivity: How board gamer players deal with progressivity (Emily Hofstetter and Jessica Robles) -- Chapter 4. Embodied noticings as repair initiations: On multiactivity in choir rehearsals (Anna Vatanen) -- Part II: Complexity that resides in asymmetries related to affordances, resources and roles -- Chapter 5. Intersubjective interaction during the word explanation activity in social virtual reality (Heidi Spets) -- Chapter 6. Building on linguistically exclusive talk: Access, participation and progressivity in a multinational military staff (Antti Kamunen and Pentti Haddington) -- Chapter 7. Nudging questions as devices for prompting courses of action and negotiating deontic (a)symmetry in UN Military Observer training (Iira Rautiainen, Pentti Haddington and Antti Kamunen) -- Part III: Complexity that resides in the coordination of participation frameworks "]
[{"$nulls":4},"-- Chapter 8. Playing together on a large screen: Spatiality, materiality, temporality and the complexity of interaction (Heike Baldauf-Quilliatre and Biagio Ursi) -- Chapter 9. Getting (others) involved with smartphones: Participation in showing sequences in multi-party settings (Iuliia Avgustis and Florence Oloff) -- Chapter 10. The primacy of affective engagement in simultaneously unfolding participation frameworks (Julia Katila, Yumei Gan, Sara Goico and Marjorie Goodwin) -- Part IV: Complexity that resides in the characteristics of interactional settings and environments -- Chapter 11. Ambulatory openings (Elliot M. Hoey) -- Chapter 12. Openings of interactions in immersive virtual reality: Identifyingand recognising prospective co-participants (Pentti Haddington, Laura Kohonen-Aho, Sylvaine Tuncer and Heidi Spets) -- Chapter 13. Transitions between interactional spaces: Working towards shared understanding in a hybrid workshop setting (Laura Kohonen-Aho)."]
[null,null,null,"Sommario/riassunto","“It is commonplace that social interaction is complex. This volume is the first to systematically explore sources and orders of this complexity in various interactional settings. It shows how technical mediation, multiactivity, the presence of several parties, the wealth of multimodal resources, and multi-sensorial perceptions create complicated and fragile constellations and processes in social encounters. In addition to fine-grained in-depth analyses of video recordings, the authors establish complexity as a theoretical lens that allows us to gain unprecedented insights into the fabrics of intersubjectivity and interactional organization in our current societies.” —Arnulf Deppermann, Professor, Leibniz Institute for the German Language, University of Mannheim Everyday social life is deeply tied to the ways in which people talk, interact, and engage in joint activities with each other. This book examines language use and social interaction through the lens of complexity, focusing on how participants establish and maintain shared understanding in multi-layered situations and settings. This book will find readership among students and scholars who use video-based methods and are interested in interaction, intersubjectivity and multimodality. Pentti Haddington is Professor of English language and interaction at the University of Oulu, Finland. Tiina Eilittä is a doctoral researcher at the University of Oulu, Finland. Antti Kamunen is a postdoctoral researcher at the University of Oulu, Finland. Laura Kohonen-Aho is a postdoctoral researcher at the University of Oulu, Finland. Iira Rautiainen is a postdoctoral researcher at the University of Oulu, Finland. Anna Vatanen is a researcher at the University of Helsinki, Finland, and also affiliated with the University of Oulu, Finland. The editors form a team that has worked together on complexity of interaction for several years in the projects iTask: Linguistic and embodied features of interactional multitasking and PeaceTalk: Talk and interaction in multinational crisis management training funded by the Academy of Finland and Eudaimonia Institute at the University of Oulu, Finland."]