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[null,"1.","Record Nr.",null,"UNINA9910743228503321"]
[null,null,"Titolo",null,"Innate lymphoid cells / / edited by Xiao-Hong Sun"]
[null,null,"Pubbl/distr/stampa",null,"Gateway East, Singapore : , : Springer, , [2022]"]
[{"$nulls":4},"©2022"]
[null,null,"ISBN",null,"981-16-8387-5"]
[{"$nulls":4},"981-16-8386-7"]
[null,null,"Descrizione fisica",null,"1 online resource (169 pages)"]
[null,null,"Collana",null,"Advances in Experimental Medicine and Biology ; ; v.1365"]
[null,null,"Disciplina",null,"612.42045"]
[null,null,"Soggetti",null,"Lymphoid tissue"]
[{"$nulls":4},"Natural immunity"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Intro -- Preface -- Contents -- 1: Overview: Themes in Innate Lymphoid Cell Biology -- 1.1 ILCs and T Cells: Identification of Two Parallel Universes -- 1.2 The Importance of Tissue Residency -- 1.3 ILC Versus T Cell Commitment: Shared and Unique Pathways -- 1.4 Where Do ILCs Develop? -- 1.5 Tregs and TFH: Why in T Cells Only? -- 1.6 ILCs: A Target for Disease Treatment? -- References -- 2: ILC Differentiation from Progenitors in the Bone Marrow -- 2.1 Introduction -- 2.2 ILC Subsets and Their Sites of Abundance -- 2.2.1 Group 1 ILC -- 2.2.2 Group 2 ILC -- 2.2.3 Group 3 ILC -- 2.3 ILC Progenitors and Steps of ILC Differentiation at Central Sites -- 2.4 Transcription Factor Requirement During Central ILC Development -- 2.4.1 NFIL3 -- 2.4.2 TOX -- 2.4.3 TCF-1 -- 2.4.4 ID2 -- 2.4.5 GATA-3 -- 2.4.6 PLZF -- 2.5 ILC Development at Extramedullary Sites -- 2.6 ILC Progenitors in Tissues -- 2.7 Tissue-Homing Features of Central ILC Progenitors -- 2.8 Multiple Developmental Waves Contributing to Adult Tissue ILC Pool -- 2.9 Local Niche Instructs Tissue ILC Development and ILC Subset Heterogeneity -- 2.10 Conclusion -- References -- 3: ILC Differentiation in the Thymus -- 3.1 Introduction -- 3.2 The Requirements for ILC Differentiation -- 3.3 The Ability of the Thymus to Support ILC Differentiation -- 3.4 Regulation of T Cell Versus ILC Fates by E Protein Transcription Factors -- 3.4.1 E Proteins and Their Inhibitors -- 3.4.2 E Proteins Are Essential for T Cell Development -- 3.4.3 Suppression of ILC2 Fates by E Proteins -- 3.4.4 Molecular Mechanisms Underlying E Protein-Mediated Suppression of ILC2 "]
[{"$nulls":4},"Differentiation -- 3.5 ILCs Made in the Thymus -- 3.5.1 ILCs Within the Thymus -- 3.5.2 Detection of TCR Rearrangement in ILC2s in the Lung -- 3.5.3 Reporter Expression in ILCs in a Thymus-Dependent Manner."]
[{"$nulls":4},"3.5.4 In Vitro Differentiation of ILC2s from T Cell Precursors -- 3.5.5 Identification of Thymus-Derived ILC Precursors in the Blood -- 3.5.6 Identification of Immature Thymus-Derived ILCs in Peripheral Tissues and Their Differentiation -- 3.6 Conclusions and Future Directions -- References -- 4: NK Cells and ILC1s in Cancer Biology -- 4.1 Introduction -- 4.2 NK Cells and ILC1s -- 4.3 NK Cell Functions -- 4.4 NK Cells and Other Tumor-Infiltrating Immune Cells -- 4.5 NK Cell Exhaustion in Cancer -- 4.6 NK Cell Metabolism and Cancer -- 4.7 ILC1s and Cancer -- 4.8 NK Cell Plasticity in Cancer -- 4.9 Concluding Remarks -- References -- 5: Finding a Niche: Tissue Immunity and Innate Lymphoid Cells -- 5.1 Introduction -- 5.2 Respiratory Tract -- 5.3 Gastrointestinal Tract -- 5.4 Skin -- 5.5 Metabolically Active Tissues -- 5.6 Conclusions -- References -- 6: ILCs and Allergy -- 6.1 Introduction -- 6.2 Innate Lymphoid Cells in the Lungs -- 6.2.1 Mechanism of IL-33-Induced Asthma -- 6.2.2 Cytokines and Lipid Mediators that Regulate the Function of ILC2s -- 6.2.3 Neuroimmune Interaction in ILC2s -- 6.2.4 The Role of ILC2s in Trained Immunity and Acquired Immunity -- 6.2.5 Treatment of ILC2-Mediated Type 2 Inflammation in the Lungs -- 6.3 Innate Lymphoid Cells in the Skin -- 6.3.1 ILC2s in Atopic Dermatitis -- 6.3.2 NK and ILC1 in Contact Hypersensitivity -- 6.4 Innate Lymphoid Cells in the Nasal Mucosa -- 6.4.1 Allergic Rhinitis and ILC2s -- 6.4.2 Chronic Rhinosinusitis and ILC2s -- 6.4.3 Nasal Allergy and ILC1s, ILC3s -- 6.5 Food Allergy, Including Anaphylaxis, and ILC2s -- 6.6 Allergic Conjunctivitis and ILC2s -- 6.7 Conclusion -- References -- 7: Innate Lymphoid Cells and Inflammatory Bowel Disease -- 7.1 Intestinal ILCs During Homeostasis -- 7.2 Roles of ILCs in Inflammatory Bowel Disease -- 7.3 Current and Future Therapies Targeting ILCs in IBD."]
[{"$nulls":4},"References -- 8: Coordination of Mucosal Immunity by Innate Lymphoid Cells -- 8.1 Introduction -- 8.2 ILCs and Microbes -- 8.2.1 Infectious Microbes and ILC Function -- 8.2.2 Direct Microbiota-Dependent Regulation of ILC Development and Function -- 8.2.3 Indirect Interactions Between the Microbiota and ILCs -- 8.3 Regulation of ILC Metabolism by Microbes -- 8.4 ILC Interaction with the Nervous System -- 8.4.1 ILCs and the Central Nervous System -- 8.4.2 ILCs and the Peripheral Nervous System -- 8.5 Concluding Remarks -- References -- 9: Interaction Between Innate Lymphoid Cells and the Nervous System -- 9.1 Introduction -- 9.2 Regulation of Innate Lymphoid Cells by the Nervous System -- 9.2.1 The Peripheral Nervous System at Mucosal Barriers -- 9.2.2 Regulation of Group 2 Innate Lymphoid Cell (ILC2) Activity by the Peripheral Nervous System -- 9.2.3 Regulation of ILC3 Response by the Neuronal Network -- 9.2.4 Regulation of NK Activity by the Neurotransmitters -- 9.3 Regulation of the Central Nervous System by Innate Lymphoid Cells -- 9.3.1 Immunity in the CNS Barriers -- 9.3.2 Regulation of CNS Function by NK Cells -- 9.3.2.1 NK Cells and Brain Tumors -- 9.3.2.2 NK Cells and Brain Infections -- 9.3.2.3 NK Cells and Brain Ischemic Stroke -- 9.3.2.4 NK Cells in Multiple Sclerosis (MS) and Experimental Autoimmune Encephalomyelitis -- 9.3.2.5 NK Cells and Neurodegeneration -- 9.3.3 Regulation of CNS Function by Group 2 Innate Lymphoid Cells -- 9.3.3.1 ILC2 and CNS Injury -- 9.3.3.2 ILC2s and Brain Infection -- 9.3.3.3 ILC2s and Multiple Sclerosis -- 9.3.3.4 ILC2s and Aging -- 9.4 CNS Lymphatics -- 9.5 Summary -- References -- 10: Development of αβ T Cells with Innate Functions -- 10.1 Introduction -- 10.2 Development in the Thymus -- 10.2.1 Generation "]
[{"$nulls":4},"of Precursor NKT and MAIT Cells -- 10.2.2 Positive Selection of Innate αβ T Cells."]
[{"$nulls":4},"10.2.3 Signals that Control Positive Selection of Innate αβ T Cells -- 10.2.4 Stages of Development -- 10.3 Colonization of Peripheral Tissues, and Cross Talk with the Microbiome -- 10.4 Conclusion -- References -- 11: The Road from Mouse to Human ILCs: A Perspective of Understanding the Roles of ILCs in Disease -- References."]