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[null,"1.","Record Nr.",null,"UNINA9910453872003321"]
[null,null,"Autore",null,"Caroli Betty Boyd"]
[null,null,"Titolo",null,"First ladies [[electronic resource] /] / Betty Boyd Caroli"]
[null,null,"Pubbl/distr/stampa",null,"New York, : Oxford University Press, c1995"]
[null,null,"ISBN",null,"1-280-56112-2"]
[{"$nulls":4},"0-19-802081-3"]
[null,null,"Edizione",null,"[Expanded ed.]"]
[null,null,"Descrizione fisica",null,"1 online resource (489 p.)"]
[null,null,"Disciplina",null,"973.099"]
[{"$nulls":4},"973.0992B"]
[{"$nulls":4},"973/.099 B"]
[null,null,"Soggetti",null,"Presidents' spouses - United States"]
[{"$nulls":4},"Politicians' spouses - United States"]
[{"$nulls":4},"Electronic books."]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Includes bibliiographical references (p. 361-414) and index."]
[null,null,"Nota di contenuto",null,"Contents; Introduction; 1. Setting Precedents: The First Presidents' Wives (1789-1829); 2. Young Substitutes for First Ladies (1829-1869); 3. Three Exceptions: Sarah Childress Polk, Mary Todd Lincoln, and Julia Dent Grant; 4. The Limited Promise of the \"\"New Woman\"\" (1877-1901); 5. The Office of First Lady: A Twentieth Century Development; 6. The Paradoxical 1920's; 7. Breaking Precedents and Reaffirming Old Ones (1933-1961); 8. The Turbulent Sixties; 9. New Dimensions to the Job of First Lady (1974-1993); 10. A New Generation in the White House (1993-); 11. Presidential Wives and the Press"]
[{"$nulls":4},"12. \"\"The Women They Married . . .\"\": Some Conclusions Notes; Appendices; Index"]
[null,null,null,"Sommario/riassunto","As we move toward the year 2000, Americans continue to debate the job of First Lady. How much power does the position actually hold? How publicly should that power be wielded? First Ladies tells the story of this curious institution and the evolution of these women's role from ceremonial backdrop to substantive world figure. This expanded edition brings us up to the present, examining the legacies of our three most recent First Ladies: Nancy Reagan, credited with raising the job to that of \"\"Associate President\"\"; Barbara Bush, who took a more traditional approach); and Hillary Rodham Clinton,"]
[null,"2.","Record Nr.",null,"UNINA9910692873303321"]
[null,null,"Autore",null,"Roberts Guy B"]
[null,null,"Titolo",null,"This arms control dog won't hunt [[electronic resource] ] : the proposed fissile material cut-off treaty at the conference on disarmament"]
[null,null,"Pubbl/distr/stampa",null,"[Colorado Springs], Colo. : , : USAF Institute for National Security Studies, USAF Academy, , [2001]"]
[null,null,"Collana",null,"INSS occasional paper ; ; 36. Arms control series"]
[null,null,"Soggetti",null,"Nuclear nonproliferation - International cooperation"]
[{"$nulls":4},"Arms control"]
[{"$nulls":4},"Disarmament"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Title from title page (viewed on Mar. 31, 2004)."]
[null,"3.","Record Nr.",null,"UNINA9910829904503321"]
[null,null,"Titolo",null,"Fragment-based approaches in drug discovery [[electronic resource] /] / edited by Wolfgang Jahnke and Daniel A. Erlanson"]
[null,null,"Pubbl/distr/stampa",null,"Weinheim, : Wiley-VCH"]
[{"$nulls":4},"[Chichester, : John Wiley, distributor], c2006"]
[null,null,"ISBN",null,"1-280-72281-9"]
[{"$nulls":4},"9786610722815"]
[{"$nulls":4},"3-527-60876-1"]
[{"$nulls":4},"3-527-60860-5"]
[null,null,"Descrizione fisica",null,"1 online resource (393 p.)"]
[null,null,"Collana",null,"Methods and principles in medicinal chemistry ; ; 34"]
[null,null,"Disciplina",null,"615"]
[{"$nulls":4},"615.1901"]
[null,null,"Soggetti",null,"Drug development"]
[{"$nulls":4},"Ligands (Biochemistry)"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Fragment-based Approaches in Drug Discovery; Contents; Preface; A Personal Foreword; List of Contributors; Part I: Concept and Theory; 1 The Concept of Fragment-based Drug Discovery; 1.1 Introduction; 1.2 Starting Small: Key Features of Fragment-based Ligand Design; 1.2.1 FBS Samples Higher Chemical Diversity; 1.2.2 FBS Leads to Higher Hit Rates; 1.2.3 FBS Leads to Higher Ligand Efficiency; 1.3 Historical Development; 1.4 Scope and Overview of this Book; References; 2 Multivalency in Ligand Design; 2.1 Introduction and Overview; 2.2 Definitions of Terms"]
[{"$nulls":4},"2.3 Selection of Key Experimental Studies2.3.1 Trivalency in a Structurally Simple System; 2.3.2 Cooperativity (and the Role of Enthalpy) in the \"Chelate Effect\"; 2.3.3 Oligovalency in the Design of Inhibitors to Toxins; 2.3.4 Bivalency at Well Defined Surfaces (Self-assembled Monolayers, SAMs); 2.3.5 Polyvalency at Surfaces of Viruses, Bacteria, and SAMs; 2.4 Theoretical Considerations in Multivalency; 2.4.1 Survey of Thermodynamics; 2.4.2 Additivity and Multivalency; 2.4.3 Avidity and Effective Concentration (C(eff)); 2.4.4 Cooperativity is Distinct from Multivalency"]
[{"$nulls":4},"2.4.5 Conformational Entropy of the Linker between Ligands2.4.6 Enthalpy/Entropy Compensation Reduces the Benefit of Multivalency; "]
[{"$nulls":4},"2.5 Representative Experimental Studies; 2.5.1 Experimental Techniques Used to Examine Multivalent Systems; 2.5.1.1 Isothermal Titration Calorimetry; 2.5.1.2 Surface Plasmon Resonance Spectroscopy; 2.5.1.3 Surface Assays Using Purified Components (Cell-free Assays); 2.5.1.4 Cell-based Surface Assays; 2.5.2 Examination of Experimental Studies in the Context of Theory; 2.5.2.1 Trivalency in Structurally Simple Systems"]
[{"$nulls":4},"2.5.2.2 Cooperativity (and the Role of Enthalpy) in the \"Chelate Effect\"2.5.2.3 Oligovalency in the Design of Inhibitors of Toxins; 2.5.2.4 Bivalency in Solution and at Well Defined Surfaces (SAMs); 2.5.2.5 Polyvalency at Surfaces (Viruses, Bacteria, and SAMs); 2.6 Design Rules for Multivalent Ligands; 2.6.1 When Will Multivalency Be a Successful Strategy to Design Tight-binding Ligands?; 2.6.2 Choice of Scaffold for Multivalent Ligands; 2.6.2.1 Scaffolds for Oligovalent Ligands; 2.6.2.2 Scaffolds for Polyvalent Ligands; 2.6.3 Choice of Linker for Multivalent Ligands"]
[{"$nulls":4},"2.6.3.1 Rigid Linkers Represent a Simple Approach to Optimize Affinity2.6.3.2 Flexible Linkers Represent an Alternative Approach to Rigid Linkers to Optimize Affinity; 2.6.4 Strategy for the Synthesis of Multivalent Ligands; 2.6.4.1 Polyvalent Ligands: Polymerization of Ligand Monomers; 2.6.4.2 Polyvalent Ligands: Functionalization with Ligands after Polymerization; 2.7 Extensions of Multivalency to Lead Discovery; 2.7.1 Hetero-oligovalency Is a Broadly Applicable Concept in Ligand Design; 2.7.2 Dendrimers Present Opportunities for Multivalent Presentation of Ligands"]
[{"$nulls":4},"2.7.3 Bivalency in the Immune System"]
[null,null,null,"Sommario/riassunto","This first systematic summary of the impact of fragment-based approaches on the drug development process provides essential information that was previously unavailable. Adopting a practice-oriented approach, this represents a book by professionals for professionals, tailor-made for drug developers in the pharma and biotech sector who need to keep up-to-date on the latest technologies and strategies in pharmaceutical ligand design. The book is clearly divided into three sections on ligand design, spectroscopic techniques, and screening and drug discovery, backed by numerous case studies."]
[null,"4.","Record Nr.",null,"UNINA9910694065903321"]
[null,null,"Titolo",null,"North Korea : an update on six-party talks and matters related to the resolution of the North Korean nuclear crisis : hearing before the Committee on Foreign Relations, United States Senate, One Hundred Ninth Congress, first session, June 14, 2005"]
[null,null,"Descrizione fisica",null,"1 online resource (iii, 35 p.)"]
[null,null,"Soggetti",null,"Nuclear disarmament - Korea (North)"]
[{"$nulls":4},"Nuclear weapons - Korea (North)"]
[{"$nulls":4},"Diplomatic negotiations in international disputes"]
[{"$nulls":4},"Nuclear nonproliferation - Korea (North) - International cooperation"]
[{"$nulls":4},"United States Foreign relations Korea (North)"]
[{"$nulls":4},"Korea (North) Foreign relations United States"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]