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[null,"1.","Record Nr.",null,"UNINA9910688412403321"]
[null,null,"Autore",null,"Shanmugasundaram Ganapathy-Kanniappan"]
[null,null,"Titolo",null,"Cancer Metabolism: Molecular Targeting and Implications for Therapy"]
[null,null,"Pubbl/distr/stampa",null,"Frontiers Media SA, 2017"]
[null,null,"Descrizione fisica",null,"1 online resource (114 p.)"]
[null,null,"Collana",null,"Frontiers Research Topics"]
[null,null,"Soggetti",null,"Medicine and Nursing"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Sommario/riassunto","Development of an effective anticancer therapeutic necessitates the selection of cancer-related or cancer-specific pathways or molecules that are sensitive to intervention. Several such critical yet sensitive molecular targets have been recognized, and their specific antagonists or inhibitors validated as potential therapeutics in preclinical models. Yet, majority of anticancer principles or therapeutics show limited success in the clinical translation. Thus, the need for the development of an effective therapeutic strategy persists. \"Altered energy metabolism\" in cancer is one of the earliest known biochemical phenotypes which dates back to the early 20th century. The German scientist, Otto Warburg and his team (Warburg, Wind, Negelein 1926; Warburg, Wind, Negelein 1927) provided the first evidence that the glucose metabolism of cancer cells diverge from normal cells. This phenomenal discovery on deregulated glucose metabolism or cellular bioenergetics is frequently witnessed in majority of solid malignancies. Currently, the altered glucose metabolism is used in the clinical diagnosis of cancer through positron emission tomography (PET) imaging. Thus, the \"deregulated bioenergetics\" is a clinically relevant metabolic signature of cancer cells, hence recognized as one of the hallmarks of cancer (Hanahan and Weinberg 2011). Accumulating data unequivocally demonstrate that, besides cellular bioenergetics, cancer metabolism facilitates several cancer-related processes including metastasis, therapeutic resistance and so on. Recent reports also demonstrate the oncogenic regulation of glucose metabolism (e.g. glycolysis) indicating a functional link between neoplastic growth and cancer metabolism. Thus, cancer metabolism, which is already "]
[{"$nulls":4},"exploited in cancer diagnosis, remains an attractive target for therapeutic intervention as well. The Frontiers in Oncology Research Topic \"Cancer Metabolism: Molecular Targeting and Implications for Therapy\" emphases on recent advances in our understanding of metabolic reprogramming in cancer, and the recognition of key molecules for therapeutic targeting. Besides, the topic also deliberates the implications of metabolic targeting beyond the energy metabolism of cancer. The research topic integrates a series of reviews, mini-reviews and original research articles to share current perspectives on cancer metabolism, and to stimulate an open forum to discuss potential challenges and future directions of research necessary to develop effective anticancer strategies."]
[null,"2.","Record Nr.",null,"UNINA9910765713603321"]
[null,null,"Autore",null,"Schneider Richard A"]
[null,null,"Titolo",null,"Cells in evolutionary biology : transLating genotypes into phenotypes - past, present, future / / edited by Brian K. Hall and Sally A. Moody"]
[null,null,"Pubbl/distr/stampa",null,"Taylor & Francis, 2018"]
[{"$nulls":4},"Boca Raton, FL : , : CRC Press, an imprint of Taylor and Francis, , 2018"]
[null,null,"ISBN",null,"9781351652025"]
[{"$nulls":4},"1351652028"]
[{"$nulls":4},"9781315155968"]
[{"$nulls":4},"1315155966"]
[{"$nulls":4},"9781498787871"]
[{"$nulls":4},"1498787878"]
[null,null,"Edizione",null,"[First edition.]"]
[null,null,"Descrizione fisica",null,"1 online resource (295 pages)"]
[null,null,"Collana",null,"Evolutionary cell biology"]
[null,null,"Disciplina",null,"572.838"]
[null,null,"Soggetti",null,"Cytology"]
[{"$nulls":4},"Natural history"]
[{"$nulls":4},"Zoology"]
[{"$nulls":4},"LIFESCIENCEnetBASE"]
[{"$nulls":4},"SCIENCE / Life Sciences / Evolution"]
[{"$nulls":4},"NATURE / Animals / General"]
[{"$nulls":4},"Evolution, Molecular"]
[{"$nulls":4},"Cell Physiological Phenomena - genetics"]
[{"$nulls":4},"Genetic Association Studies"]
[{"$nulls":4},"Genotype"]
[{"$nulls":4},"Phenotype"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Nota di bibliografia","Includes bibliographical references."]
[null,null,"Nota di contenuto",null,"chapter 1 The Role of Cells and Cell Theory in Evolutionary Thought, circa 1840-1872 -- chapter 2 Germ Cells and Somatic Cells in Evolutionary Biology: August Weismann's Germ Plasm Theory -- chapter 3 Cell Lineages in Ontogeny and Phylogeny from 1900 -- chapter 4 Protists and Multiple Routes to the Evolution of Multicellularity -- chapter 5 Symbiosis in Eukaryotic Cell Evolution: Genomic Consequences and Changing Classification -- chapter 6 Cellular Signaling Centers and the Maintenance and Evolution of "]
[{"$nulls":4},"Morphological Patterns in Vertebrates -- chapter 7 Cellular Control of Time, Size, and Shape in Development and Evolution -- chapter 8 Cellular Basis of Evolution in Animals: An Evo-Devo Perspective -- chapter 9 Dynamical Patterning Modules Link Genotypes to Morphological Phenotypes in Multicellular Evolution."]
[null,null,null,"Sommario/riassunto","This book is the first in a projected series on Evolutionary Cell Biology, the intent of which is to demonstrate the essential role of cellular mechanisms in transforming the genotype into the phenotype by transforming gene activity into evolutionary change in morphology. This book —Cells in Evolutionary Biology — evaluates the evolution of cells themselves and the role cells have been viewed to play as agents of change at other levels of biological organization. Chapters explore Darwin’s use of cells in his theory of evolution and how Weismann’s theory of the separation of germ plasm from body cells brought cells to center stage in understanding how acquired changes to cells within generations are not passed on to future generations. The study of evolution through the analysis of cell lineages during embryonic development dominated evolutionary cell biology until usurped by the switch to genes as the agents of heredity in the first decades of the 20th century. Discovery that cells exchanged organelles via symbiosis led to a fundamental reevaluation of prokaryotic and eukaryotic cells and to a reorganizations of the Tree of Life. Identification of cellular signaling centers, of mechanisms responsible for cellular patterning, and of cell behavior and cellular condensations as mediating the plasticity that enables phenotypic change during evolution, provided powerful new synergies between cell biology and evolutionary theory and the basis for Evolutionary Cell Biology."]