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[null,"1.","Record Nr.",null,"UNINA9910688341403321"]
[null,null,"Autore",null,"Giuseppe Rengo"]
[null,null,"Titolo",null,"The adrenergic system in cardiovascular physiology and pathophysiology [[electronic resource] /] / edited by: Giuseppe Rengo"]
[null,null,"Pubbl/distr/stampa",null,"Frontiers Media SA, 2015"]
[{"$nulls":4},"[Lausanne, Switzerland] : , : Frontiers Media SA, , 2015"]
[{"$nulls":4},"©2015"]
[null,null,"Edizione",null,"[Second edition.]"]
[null,null,"Descrizione fisica",null,"1 online resource (78 pages) : illustrations; digital, PDF file(s)"]
[null,null,"Collana",null,"Frontiers Research Topics"]
[{"$nulls":4},"Frontiers in Physiology"]
[null,null,"Soggetti",null,"Cardiovascular system - Diseases"]
[{"$nulls":4},"Cardiovascular system - Diseases - Pathogenesis"]
[{"$nulls":4},"Cardiovascular system - Diseases - Prevention - Research"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Nota di bibliografia","Includes bibliographical references."]
[null,null,null,"Sommario/riassunto","Cardiovascular diseases pose an enormous clinical challenge, remaining the most common cause of death in the world. β-adrenoceptors play an important role on cardiac, vascular and/or endothelial function at a cellular level with relevant applications in several cardiovascular diseases, such as heart failure and hypertension. G protein–coupled receptors (GPCRs), including β-adrenergic receptors, constitute the most ubiquitous superfamily of plasma membrane receptors and represent the single most important type of therapeutic drug target. Sympathetic nervous system hyperactivity, which characterizes several cardiovascular diseases, such as heart failure and hypertension, as well as physiological ageing, has been proved to exert in the long-term detrimental effects in a wide range of cardiovascular diseases. Acutely, sympathetic hyperactivity represents the response to an insult to the myocardium, aiming to compensate for decreased cardiac output. This process involves the activation of beta-adrenergic receptors by catecholamine with consequent heart rate and cardiac contractility increase. However, long-term exposure of the heart to elevated norepinephrine and epinephrine levels, originating from sympathetic nerve endings and chromaffin cells of the adrenal gland, results in further progressive deterioration in cardiac structure and "]
[{"$nulls":4},"function. At the molecular level, sustained sympathetic nervous system hyperactivity is responsible for several alterations including altered beta-adrenergic receptor signaling and function (down-regulation/desensitization). Moreover, the detrimental effects of catecholamine affect also the function of different cell types including, but not limited to, endothelial cells, fibroblasts and smooth muscle cells. Thus, the success of beta-blocker therapy is due, at least in part, to the protection of the heart and the vasculature from the noxious effects of augmented catecholamine levels. The current research topic aims to support the progress towards understanding the role of sympathetic nervous system under physiological conditions, and the contribution of its hyperactivity in the pathogenesis and progression of cardiovascular diseases. The topic is open to original studies, descriptions of new methodologies, reviews and opinions."]
[null,"2.","Record Nr.",null,"UNINA9910815726503321"]
[null,null,"Autore",null,"Kallen Jeffrey L"]
[null,null,"Titolo",null,"Irish English . Volume 2 The Republic of Ireland / / Jeffrey L. Kallen"]
[null,null,"Pubbl/distr/stampa",null,"Boston ; ; Berlin : , : De Gruyter Mouton, , [2013]"]
[{"$nulls":4},"©2013"]
[null,null,"ISBN",null,"1-61451-129-2"]
[null,null,"Descrizione fisica",null,"1 online resource (328 p.)"]
[null,null,"Collana",null,"Dialects of English, , 2164-7445 ; ; volume 9"]
[null,null,"Disciplina",null,"427/.9417"]
[null,null,"Soggetti",null,"English language - Dialects - Ireland"]
[{"$nulls":4},"English language - Ireland"]
[{"$nulls":4},"English language - Ireland - Discourse analysis"]
[{"$nulls":4},"English language - Social aspects - Ireland"]
[{"$nulls":4},"English language - Variation - Ireland"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references (pages [272]-303) and index."]
[null,null,"Nota di contenuto",null,"Frontmatter -- Preface -- Acknowledgements -- Map of Ireland -- Content -- List of abbreviations -- 1 Geography, demography, and cultural factors -- 2 Phonetics and phonology -- 3 Morphosyntax -- 4 Lexis and discourse features -- 5 History, including changes in progress -- 6 Survey of previous work -- 7 Sample texts -- References -- Index"]
[null,null,null,"Sommario/riassunto","This volume continues the Dialects of English series, and complements Irish English volume 1: Northern Ireland, by Karen Corrigan. Focusing on Irish English in the Republic of Ireland, the book starts by exploring the often oppositional roles of national language development and globalisation in shaping Irish English from the earliest known times to the present. Three chapters on the lexicon and discourse, syntax, and phonology focus on traditional dialect but also refer to colloquial and vernacular Irish English, the use of dialect in literature, and the modern \"standard\" language, especially as found in the International Corpus of English (ICE-Ireland). A separate chapter examines the internal history of Irish English, from Irish Middle English to contemporary change in progress. The book includes an extended bibliographical essay and a set of sample literary texts and texts from ICE-Ireland. Continuing themes include the impact on Irish English of contact with the Irish language, the position of Irish English in world Englishes, and features which help to distinguish between Irish English in the Republic and in "]
[{"$nulls":4},"Northern Ireland."]