{"text_format":"2","workbook":"xls","n_sheets":1,"sheets":["report2"],"not_rendered":{"charts":0,"images":0,"macros":0,"external_links":1,"defined_names":2,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"run_cost":"one","rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"report2","index":0,"n_rows":26,"n_cols":5,"rows_kept":26,"cut":false,"hidden":false,"merged":[[0,2,0,3],[0,4,0,5],[1,2,1,3],[1,4,1,5],[2,2,2,3],[3,2,3,3],[4,2,4,3],[5,2,5,3],[6,2,6,3],[7,2,7,3],[8,2,8,3],[11,2,11,3],[11,4,11,5],[12,2,12,3],[12,4,12,5],[13,2,13,3],[14,2,14,3],[15,2,15,3],[16,2,16,3],[23,2,23,3],[24,2,24,3]],"flags":["formulas_cached_only"]}
[null,"1.","Record Nr.",null,"UNINA9910683366003321"]
[null,null,"Titolo",null,"Model-Informed Precision Dosing / / edited by Jonás Samuel Pérez-Blanco, José Martínez Lanao"]
[null,null,"Pubbl/distr/stampa",null,"Basel : , : MDPI - Multidisciplinary Digital Publishing Institute, , 2023"]
[null,null,"ISBN",null,"3-0365-6897-2"]
[null,null,"Descrizione fisica",null,"1 online resource (320 pages)"]
[null,null,"Disciplina",null,"615.14"]
[null,null,"Soggetti",null,"Drugs - Dosage"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Sommario/riassunto","Model-informed precision dosing (MIPD) is an advanced quantitative approach focusing on individualized treatment optimization. MIPD integrates mathematical models of drugs and diseases combined with individual patient characteristics (e.g., genotype, anthropometric factors, and organ function). MIPD has been highlighted as a useful tool for drug dosage selection in both the drug development process and clinical practice and it is a rapidly growing discipline that is supported by the main drug regulatory agencies. Despite the potential benefits of this methodology toward personalized medicine, its application is still limited. The Special Issue presented here includes several PKPD and PBPK models focused on improving the current state of art regarding the PK behaviour of different drugs with the aim of improving the efficacy/safety balance of these treatments and their clinical outcome; the Special Issue is intended to be of particular interest for clinical pharmacologists, pharmacometricians, and specific clinicians who routinely use the considered drugs."]
[null,"2.","Record Nr.",null,"UNICAMPANIAVAN00101394"]
[null,null,"Titolo",null,"Evolutionary equations with applications in natural sciences / Jacek Banasiak, Mustapha Mokhtar-Kharroubi editors"]
[null,null,"Pubbl/distr/stampa",null,"Cham, : Springer, 2015"]
[null,null,"Titolo uniforme",null,"Evolutionary equations with applications in natural sciences"]
[null,null,"Descrizione fisica",null,"XI, 493 p. ; 24 cm"]
[null,null,"Soggetti",null,"34Gxx - Differential equations in abstract spaces [MSC 2020]"]
[{"$nulls":4},"35Kxx - Parabolic equations and parabolic systems [MSC 2020]"]
[{"$nulls":4},"35Qxx - Partial differential equations of mathematical physics and other areas of application [MSC 2020]"]
[{"$nulls":4},"47Dxx - Groups and semigroups of linear operators, their generalizations and applications [MSC 2020]"]
[{"$nulls":4},"60Jxx - Markov processes [MSC 2020]"]
[{"$nulls":4},"65Mxx - Numerical methods for partial differential equations, initial value and time-dependent initial-boundary value problems [MSC 2020]"]
[{"$nulls":4},"92Bxx - Mathematical biology in general [MSC 2020]"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]