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[null,null,"Titolo",null,"Handbook of oxidative stress in cancer : therapeutic aspects / / edited by Sajal Chakraborti"]
[null,null,"Pubbl/distr/stampa",null,"Gateway East, Singapore : , : Springer, , [2022]"]
[{"$nulls":4},"©2022"]
[null,null,"ISBN",null,"9789811654220"]
[{"$nulls":4},"9789811654213"]
[null,null,"Descrizione fisica",null,"1 online resource (4076 pages)"]
[null,null,"Disciplina",null,"610.73"]
[null,null,"Soggetti",null,"Cancer - Treatment"]
[{"$nulls":4},"Cancer - Pathophysiology"]
[{"$nulls":4},"Oxidative stress"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Intro -- Preface -- Contents -- About the Editor -- Contributors -- Part I: Therapeutic Implications of Natural Compounds -- 1 Elimination of Senescent Cells by Polyphenols and Flavonoids -- Introduction -- Cellular Senescence -- Markers of Cellular Senescence -- Senescence-Associated Mitochondrial Dysfunction (SAMD) -- Senescence-Associated Secretory Phenotype (SASP) -- Bystander Effect -- Therapy-Induced Senescence (TIS) -- TIS Induced by Polyphenols -- Escape From TIS -- Senescent Cells: A Survival Niche Generating a Complex Tumor Environment -- Importance of TIS by the Example of Radiotherapy-Induced Senescence -- Role of TIS in Other Cancer Treatments -- Polyphenols Inhibiting SASP (Senostatics) -- Apigenin -- Epigallocatechin-3-Gallate (EGCG) -- Resveratrol -- Quercetin -- Polyphenols as Senolytics (Polyphenols Killing Senescent Cells) -- Fisetin -- Quercetin -- Epigallocatechin-3-Gallate (EGCG) -- Curcumin -- Herbal Extracts with Senolytic and Senomorphic Properties -- Extract of the Plant Solidago virgaurea Subsp. alpestris -- Alcoholic Extract of Ajuga taiwanensis -- Pinellia ternata Tuber -- Olive Plant -- Conclusion -- References -- 2 Natural Dietary Alkaloids and Its Synthetic Derivatives as Oxidative Stress-Inducing Agents for Cancer Therapy -- Introduction -- Berberine -- Piperine -- Neferine -- Piperlongumine -- Conclusion -- References -- 3 Natural Therapeutic Strategies for Modulating Oxidative Stress in Cancer -- Introduction -- "]
[{"$nulls":4},"Oxidative Stress and Carcinogenesis -- Antioxidant Defense Mechanism -- Oxidative Stress and Natural Compounds -- The Role of Antioxidant Potential of Phytochemicals in Oxidative Stress -- Mechanism of Natural Compounds in Combination with Chemotherapy -- Marine Product with Antioxidative Stress Activity -- Microbial Antioxidative Stress Compounds -- Conclusion -- Future Perspective -- References."]
[{"$nulls":4},"4 Antioxidant in Cancer -- Introduction -- Reactive Oxygen Species (ROS) -- Reactive Oxygen Species (ROS) in Cancer -- Antioxidants -- Antioxidants Types -- Defense Mechanism of Antioxidant -- Antioxidant: Preventer of Cancer -- Antioxidant: Promoter of Cancer -- Antioxidant: An Achilles´ Heel -- The Antioxidant Conundrum: Friend or Foe -- Conclusion -- References -- 5 Antioxidant Activity of Phytochemicals in Cancer -- Introduction -- Role of Reactive Oxygen Species (ROS) in Cancer Progression -- ROS and Chemoresistance Development -- Cellular Redox System and Molecular Mechanisms Against ROS -- Phytochemicals and Their Antioxidant Activity in Cancer -- Triphala -- Resveratrol -- Indole-3 Carbinol (I3C) -- Peucedanum Chenur -- Astaxanthin -- Quercetin -- Ellagic Acid -- Caryophyllene Sesquiterpenes -- Phlorotannins -- The Antioxidant/Pro-oxidant Enigma of Cancer Therapy -- Phytochemicals as Immunotherapy Adjuvants -- Conclusion and Future Perspectives -- References -- 6 Therapeutic Application of Microbial Metabolites in Free Radical-Induced Tumorigenesis -- Introduction -- Role of ROS in Tumorigenesis -- Antioxidant Compounds from Microbial Sources -- Role of Secondary Metabolites of Actinobacteria in Anticancer Activity -- Role of Exopolysaccharides of Lactic Acid Bacteria in Anticancer Activity -- Effect of Bacterial Toxins and Enzymes on Anti-tumorigenesis -- Role of Biosurfactants from Microorganisms in Antitumor Therapy -- Conclusion and Future Perspectives -- References -- 7 Therapeutic Potential of Natural Agents Against Oxidative Stress-Influenced Colitis-Associated Cancer -- Introduction -- Colitis-Associated Cancer (CAC) -- Sources of Free Radicals in the Colon -- Food -- Obesity -- Age -- Reactive Oxygen Species (ROS) -- Role of ROS in CAC -- Natural Agents and Its Mechanism of Action on CAC -- Mechanism of Action of Procyanidin B on CAC."]
[{"$nulls":4},"Mechanism of Action of Shaoyao Decoction on CAC -- Mechanism of Action of Red Ginseng Oil on CAC -- Mechanism of Action of Caffeic Acid Phenethyl Ester on CAC -- Mechanism of Action of Lyophilized Acai Pulp on CAC -- Protocatechuic Acid on CAC -- Betaine on CAC -- Sasa quelpaertensis Leaf Extract on CAC -- Oligonol on CAC -- Embelin on CAC -- Phytosomal Curcumin on CAC -- Rutaecarpine on CAC -- Vanillin on CAC -- Huangqin Decoction on CAC -- American Ginseng on CAC -- Hydroxychloroquine on CAC -- Conclusion -- Future Directions -- References -- 8 Oxidative Stress: A Double Edged Sword in Cancer -- Introduction -- Tetrandrine as ROS Scavenger -- Tetrandrine-Induced ROS-Mediated Autophagy -- Tetrandrine-Induced ROS-Mediated Apoptosis -- Conclusion -- References -- 9 Prevention of Fertility due to Chemotherapy-Induced Ovarian Failure: Role of Therapeutic Antioxidants -- Introduction -- Types of Cytotoxic Drugs -- Pathways of Chemotherapy-Induced Ovarian Damage -- Chemotherapy-Induced Oxidative Stress -- Cellular Background of Oxidative Stress -- Redox State and Oxidative Stress -- Antioxidant System and Use of Antioxidants During Chemotherapy -- Adjuvant Antioxidants -- Vitamin C and Vitamin E -- Melatonin -- Other Antioxidants -- Conclusion and Future Perspective -- References -- 10 Therapeutic Implications of Phytochemicals in ROS-Induced Cancer -- Introduction -- Reactive Oxygen Species in Cancer -- Carcinogenesis "]
[{"$nulls":4},"and Phytochemicals -- Chemoprevention: Types and Approaches -- Dietary Phytochemicals: Role in Cancer Chemoprevention -- Phytochemicals: Polyphenols -- Flavonoids -- Apigenin -- Isoflavonoids -- Anthocyanidins -- Phytoestrogens -- Resveratrol -- Curcumin -- Terpenoids -- Carotenoids -- Lycopene -- Limonoids -- Glucosinolates -- α-Linolenic Acid (ALA) -- Allicin -- Silymarin -- Sulforaphane (SFN) -- Conclusions -- References."]
[{"$nulls":4},"11 Nutraceuticals in Cancer Therapy -- Introduction -- Nutraceuticals and Cancer -- Flavonoids and Polyphenols -- Catechins -- Theaflavins and Thearubigins -- Flavonoids -- Non-flavonoidal Anti-cancer Nutraceuticals -- Organosulfur Compounds -- Sulforaphane (SLFN) -- Glucobrassicin and Indole-3-Carbinol -- Diallyl-Disulfide and Thiosulfinates -- Carotenoids -- Resveratrol -- Curcumin -- Cancer and Diet -- Molecular Biology Effects -- Effect of Nutritional Support on Cancer Patients -- Nutraceuticals: Challenges and Perspectives -- Conclusion -- References -- 12 Potential Natural Product-Derived Compounds for Lung Cancer Therapy -- Lung Cancer -- Types and Staging of Lung Cancer -- Lung Cancer and Oxidative Stress Potential Sources -- Oxidative Stress and Biological Effects -- Apoptotic Cell Death and Oxidative Stress -- Apoptosis -- Potentials Targets of Drug Action in Relevance to Reactive Oxygen Species and Redox Regulation -- Misfolded Proteins, Reactive Oxygen Species (ROS), and the Endoplasmic Reticulum Stress (ER Stress) -- ER Stress as a Target for Lung Cancer Treatment -- CSC and Oxidative Stress in Lung Cancer -- Natural Product Derived Compounds -- New Anticancer Compounds from Plants -- Gallic Acid -- Curcumin -- Flavonoids -- Green Tea Polyphenols -- Genistein -- Tangeretin -- Resveratrol -- Lectins -- Natural Product-Derived Compound Regulating Mitochondrial Pathway -- Gracillin -- Quercetin -- Resveratrol -- Pterostilbene -- Honokiol -- Betulinic Acid -- Marine-Derived Compounds for Cancer Treatment -- Ecteinascidin Alkaloids -- Psammaplin A -- Didemnin B -- Dolastatin 10 -- Halichondrin B -- References -- 13 Role of Dietary Antioxidants in Chemoprevention of Nitrosamines-Induced Carcinogenesis -- Introduction -- Causes of Chemical Carcinogenesis -- Carcinogenicity of N-nitroso Compounds -- Dietary Cancer Prevention -- Chemoprevention."]
[{"$nulls":4},"Dietary Intervention -- Lycopene -- Vitamins -- Carotenoids -- Isothiocyanates -- Polyphenols -- Flavonoids -- Calcium -- Astaxanthin -- Conclusion -- Future Direction -- References -- 14 Natural Antioxidants for the Prevention and Treatment of Cancer -- Introduction -- Free Radicals, Oxidative Processes, and Cell Changes -- Secondary Metabolites, Sources, and Nutritional Implications -- Herbal Bioactive Compounds and their Molecular Targets -- Benefits and Risks of Concomitant Use of Secondary Metabolites and Cytotoxic Drugs -- Novel Uses of Secondary Metabolites in Cancer Research -- Conclusions and Future Directions -- References -- 15 Protective Effect of Quercetin, Luteolin, and Fisetin via Stimulating the p53-Mediated Signaling in Cancer -- Introduction -- Structure of p53 -- Regulation of p53 Level and Activity -- Physiological Functions of p53 -- Cell Cycle Regulation -- Induction of Apoptosis -- p53 in Response to DNA Damage -- p53 Targets Survival Signaling -- p53 and Its Cross Talk with Other Signaling Pathways -- p53 and Its Cross Talk with NF-κB -- p53 and Oxidative Stress -- Conclusion -- Future Perspective -- References -- 16 Flavonoids and Its Anticancer Activity for ROS-Induced Breast Cancer -- Introduction -- ROS Level and Cellular Homeostasis -- ROS in Cancer Signaling Pathway -- Flavonoids as Anticancer Agents -- Chemistry and Classification -- Absorption, Metabolism, and Bioavailability of Flavonoids -- Anticancer Effects of "]
[{"$nulls":4},"Flavonoid -- Effect of Flavonoids on Breast Cancer -- Molecular Mechanism of Action -- Flavonoids for Breast Cancer -- Conclusion -- References -- 17 Role of Indian Ginseng Withaferin A in ROS-Induced Cancer Chemoprevention and Cancer Therapy -- Introduction -- Plant Distribution and Phylogeny -- Chemical Constituents of Ashwagandha Roots -- Pharmacological Effects of Withania somnifera."]
[{"$nulls":4},"Anti-inflammatory Properties."]