{"text_format":"2","workbook":"xls","n_sheets":1,"sheets":["report2"],"not_rendered":{"charts":0,"images":0,"macros":0,"external_links":1,"defined_names":1,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"run_cost":"one","rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"report2","index":0,"n_rows":22,"n_cols":5,"rows_kept":22,"cut":false,"hidden":false,"merged":[[0,2,0,3],[0,4,0,5],[1,2,1,3],[1,4,1,5],[2,2,2,3],[2,4,2,5],[3,2,3,3],[5,2,5,3],[7,2,7,3],[8,2,8,3],[9,2,9,3],[10,2,10,3],[11,2,11,3],[13,2,13,3]],"flags":["formulas_cached_only"]}
[null,"1.","Record Nr.",null,"UNINA9910595595103321"]
[null,null,"Autore",null,"P. M Visakh"]
[null,null,"Titolo",null,"Nanomaterials and Nanotechnology in Medicine"]
[null,null,"Pubbl/distr/stampa",null,"Newark : , : John Wiley & Sons, Incorporated, , 2022"]
[{"$nulls":4},"©2022"]
[null,null,"ISBN",null,"1-119-55802-6"]
[{"$nulls":4},"1-119-55804-2"]
[null,null,"Descrizione fisica",null,"1 online resource (577 pages)"]
[null,null,"Disciplina",null,"610.28"]
[null,null,"Soggetti",null,"Electronic books."]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,"Nota di contenuto",null,"Cover -- Title Page -- Copyright Page -- Contents -- List of Contributors -- Preface -- Chapter 1 Nanomaterials and Nanotechnology in Medicine: Medical Applications: Challenges and Opportunities -- 1.1 Nanoneurology -- 1.2 Nanomolecular Diagnostics -- 1.3 Nanopharmaceuticals -- 1.4 Role of Nanotechnology in Biological Therapies -- 1.5 Nanomaterials for Gene Therapy -- 1.6 Nanotools for the Treatment of Ocular Diseases -- 1.7 Nanotechnology Applications in Food and Nutrition Science -- 1.8 Rubber Nanocomposites for Biomedical Applications -- References -- Chapter 2 Nanoneurology -- 2.1 Introduction and Recent Advances -- 2.2 Types of Nanomaterials -- 2.3 Nanomaterial Applications for Neurodegenerative Diseases -- 2.3.1 Alzheimer's Disease -- 2.3.2 Parkinson's Disease -- 2.4 Nanomaterial Applications for Strokes -- 2.5 Nanomaterial Applications for Spinal Cord Injuries -- 2.6 Nanomaterial Applications for Brain Tumors -- 2.7 Adverse Effects of Nanomaterials -- 2.8 Regulatory Issues -- 2.9 Conclusions -- References -- Chapter 3 Nanomolecular Diagnostics -- 3.1 Introduction -- 3.1.1 Molecular Diagnostics -- 3.1.2 Molecular Diagnostic Techniques -- 3.1.3 Molecular Diagnostics of Infectious Diseases -- 3.2 Nanodiagnostics -- 3.3 Nanoparticles for Molecular Diagnostics -- 3.3.1 Nanowires -- 3.3.2 Nanotubes -- 3.3.3 Quantum Dots -- 3.3.4 Nanopores -- 3.3.5 Nanoneedles -- 3.3.6 Nanorobots -- 3.3.7 Nanoscale Cantilevers -- 3.4 Applications of Nanoparticles for Molecular Diagnostics -- 3.4.1 Nanoparticle-Based Molecular Diagnostics for Cardiovascular Diseases -- 3.4.2 Nanoparticle-Based Molecular Diagnostics for Cancer "]
[{"$nulls":4},"Diagnosis -- 3.4.3 Nanoparticle-Based Molecular Diagnostics for CNS Diseases -- 3.4.4 Nanoparticle-Based Molecular Diagnostics for Infectious Diseases -- 3.5 Comparison Between Nanomaterials and Other Materials in Molecular Diagnostics."]
[{"$nulls":4},"3.6 Prospects of Nanodiagnostics -- 3.7 Regulatory Issues -- 3.8 Conclusion -- References -- Chapter 4 Nanopharmaceuticals -- 4.1 Introduction -- 4.2 Liposomes in Nanopharmaceuticals -- 4.3 Polymeric Nanoparticles in Nanopharmaceuticals -- 4.4 Solid Lipid Nanoparticles in Nanopharmaceuticals -- 4.5 Dendrimers in Nanopharmaceuticals -- 4.6 Quantum Dots in Nanopharmaceuticals -- 4.7 Regulatory Issues -- 4.8 Conclusion -- References -- Chapter 5 Role of Nanotechnology in Biological Therapies -- 5.1 Introduction -- 5.2 Biological Therapies -- 5.2.1 Immunotherapy -- 5.2.2 Gene Therapy -- 5.2.3 Targeted Therapy -- 5.3 Nanoparticles in Biological Therapies -- 5.3.1 Biocompatible Nanoparticles -- 5.3.2 Nanoparticle-Based Drug Delivery Systems -- 5.3.3 Nanoparticle-Based DNA and RNA Delivery Systems -- 5.3.4 Nanoparticle-Based Targeted Therapy -- 5.4 Application of Nanotechnology in Biological Therapies -- 5.4.1 Drug Delivery Nanosystems in Oncology -- 5.4.2 Nanoparticle-Based Targeted Radiotherapy -- 5.5 Advantages and Disadvantages of Nanoparticles in Biological Therapies -- 5.6 Conclusion -- References -- Chapter 6 Nanomaterials for Gene Therapy -- 6.1 Introduction and Recent Advances -- 6.2 Nanomaterials and their Physicochemical Properties -- 6.2.1 Size and Shape -- 6.2.2 Surface Charge -- 6.2.3 Surface-to-Volume Ratio -- 6.3 Methods of Characterizing the Physicochemical Properties of Nanomaterials -- 6.4 Target Organ Biocompatibility/Toxicity -- 6.4.1 Mechanism of Potential Cytotoxic Effects of Nanomaterials -- 6.4.2 Biological Defense System against Nanomaterial -- 6.5 Gene Delivery -- 6.5.1 Gene-delivery Vectors -- 6.5.2 Intracellular Uptake and Trafficking -- 6.5.3 Gene Regulation -- 6.6 Regulatory Issues -- References -- Chapter 7 Nanotools for the Treatment of Ocular Diseases -- 7.1 Introduction -- 7.2 Ocular Anatomy."]
[{"$nulls":4},"7.3 Physiological Barriers in the Eye -- 7.3.1 Tear Fluid (Lacrimal Fluid) -- 7.3.2 Cornea -- 7.3.3 Vitreous Humor -- 7.3.4 Blood-Retinal Barrier -- 7.4 Methods of Ocular Disease Treatment -- 7.5 Nanomedicine in Ocular Therapy -- 7.5.1 Nanoparticle-based Systems -- 7.5.2 Improving Strategies in Nanomedicine for Ocular Therapy -- 7.5.3 Contact Lenses -- 7.6 Closing Remarks -- Conflict of Interest -- References -- Chapter 8 Nanotechnology Applications in Food and Nutrition Science -- 8.1 Introduction -- 8.2 Nanostructured Delivery Systems -- 8.2.1 Nanocarriers -- 8.2.2 Colloidosomes -- 8.2.3 Cubosomes -- 8.2.4 Archaesomes -- 8.2.5 Nanocochleates -- 8.2.6 Biopolymeric Nanoparticles -- 8.2.7 Liposomes -- 8.2.8 Nanolaminate -- 8.2.9 Nanofibers -- 8.2.10 Dendrimers -- 8.2.11 Hydrogel Nanoparticles -- 8.2.12 Polymeric Nanoparticles -- 8.2.13 Carbon-based Nanocarriers -- 8.2.14 Quantum Dots -- 8.2.15 Nanoemulsions -- 8.3 Nanoparticles Based on Inorganic Materials -- 8.3.1 TiO2 and Ti-N Nanoparticles -- 8.3.2 Silica Nanoparticles -- 8.3.3 Carbon Nanotubes -- 8.4 Metal Nanoparticles -- 8.4.1 Nano Zinc Oxide -- 8.4.2 Iron Oxide Nanoparticles -- 8.4.3 Selenium Nanoparticles -- 8.5 Conclusion -- References -- Chapter 9 Rubber Nanocomposites for Biomedical Applications -- 9.1 Introduction -- 9.2 Rubbers for Biomedical Applications -- 9.2.1 Silicone Rubber -- 9.2.2 Polyurethanes -- 9.2.3 Thermoplastic Elastomers -- 9.3 Rubber-based Nanocomposites -- 9.3.1 Silicone Rubber Nanocomposites -- 9.3.2 Polyurethane Nanocomposites -- 9.3.3 Natural Rubber Nanocomposites -- 9.4 Conclusions -- References -- Chapter 10 "]
[{"$nulls":4},"Nanomaterials and Nanotechnology in Medicine: Materials Development: Challenges and Opportunities -- 10.1 Nanomaterials and Scaffolds for Tissue Engineering and Regenerative Medicine -- 10.2 Nanorobotics in Nanomedicine -- 10.3 Nanosensors."]
[{"$nulls":4},"10.4 Inorganic Nanoparticles for Drug-delivery Applications -- 10.5 Intelligent Nanomaterials for Medicine -- 10.5.1 Nanocomposite -- 10.5.2 In vivo tests -- 10.6 Polymer-based Nanocomposites for Biomedical Applications -- 10.7 Toxicity of Nanomaterials -- 10.8 Multifunctional Nanomaterials for Medical Applications -- 10.9 Antimicrobial Applications of Nanoparticles -- References -- Chapter 11 Nanomaterials and Scaffolds for Tissue Engineering and Regenerative Medicine -- 11.1 Introduction and Recent Advances -- 11.2 Tissue Engineering and Regenerative Medicine: General Concepts -- 11.3 Implantable Nanomaterials to Regenerate Living Tissues -- 11.4 Nanomaterials as Carriers for Therapeutic Agents -- 11.5 Nanofibrous Scaffolds -- 11.6 Nano-topography Techniques for Tissue-engineered Scaffolds -- 11.7 Regulatory Issues -- 11.8 Conclusion -- References -- Chapter 12 Nanorobotics in Nanomedicine -- 12.1 Introduction -- 12.2 What is Nanorobotics? -- 12.3 Nanorobotics in Nanomedicines -- 12.4 Nanorobots for Medical Imaging -- 12.5 Nanorobots for Targeted Drug Delivery -- 12.5.1 Bacterial, Viral, and Parasitic Infection -- 12.5.2 Cancer -- 12.5.3 Cardiovascular Disease -- 12.5.4 Cerebrovascular Disease -- 12.5.5 Hormonal, Metabolic, and Genetic Disease -- 12.5.6 Kidney Diseases -- 12.5.7 Retinal Diseases -- 12.6 Enzymatic Nanolithography -- 12.7 Biomimetic Approach -- 12.8 Cell Biochips -- 12.9 Nanorobots for Precision Surgery -- 12.10 Nanorobots for Detoxification -- 12.11 Fabrication of Nanorobots -- 12.11.1 Microfabrication -- 12.11.2 Nanofabrication -- 12.12 Toxicity -- 12.13 Administration and Retrieval -- 12.14 Clinical Presence of Nanorobots -- 12.15 Reproducibility and Standardization -- 12.16 Regulatory Issues -- 12.16.1 The FDA and Nanorobots -- 12.16.2 PTO and Nanorobots -- 12.17 Conclusion -- References -- Chapter 13 Nanosensors."]
[{"$nulls":4},"13.1 Introduction and Recent Advances -- 13.1.1 What are Nanosensors? -- 13.1.2 Why are they Important? -- 13.1.3 How Nanosensors Work -- 13.1.4 Some Recent Advancements in Nanosensors -- 13.2 Classification of Nanosensors -- 13.2.1 Mechanical Nanosensors -- 13.2.2 Gas Nanosensors -- 13.2.3 Optical Nanosensors -- 13.2.4 Fiber Optic Nanosensors -- 13.2.5 Nanosensors for Electrical Current Measurement -- 13.2.6 Magnetic Nanosensors -- 13.2.7 Biosensors -- 13.2.8 Nanosensors Based on Nanoparticles and Nanoclusters -- 13.2.9 Nanosensors Based on Nanowires, Nanofibers, and CNTs -- 13.2.10 Nanosensors Based on Graphene -- 13.2.11 Nanosensors Based on Bulk Nanostructured Materials -- 13.2.12 Nanosensors Based on Metal-organic Frameworks -- 13.3 Nanosensor Fabrication -- 13.3.1 Top-down Methods -- 13.3.2 Bottom-up Methods -- 13.3.3 Molecular Self-assembly -- 13.4 Inorganic Nanosensors -- 13.4.1 Materials Used -- 13.5 Biopolymer-derived Nanosensors -- 13.5.1 Materials Used -- 13.6 Applications -- 13.6.1 Drug Discovery -- 13.6.2 Monitoring the Effect of Drugs in Mammalian Cell -- 13.6.3 Cancer Diagnosis -- 13.6.4 Tumor Detection -- 13.6.5 Glucose Monitoring -- 13.6.6 pH Sensing -- 13.6.7 Asthma Detection -- 13.6.8 Cell Monitoring -- 13.6.9 Microorganism Detection -- 13.6.10 Protein and DNA Detection -- 13.6.11 Contamination in Organic Implant -- 13.6.12 Astronaut's Diagnosis -- 13.6.13 Other Diagnosis -- 13.6.14 Other Examples of Nanosensor Applications -- 13.7 Regulatory Issues -- 13.8 Conclusions -- References -- Chapter 14 Inorganic Nanoparticles for "]
[{"$nulls":4},"Drug-delivery Applications -- 14.1 Introduction -- 14.2 Synthesis of Inorganic Nanoparticles -- 14.2.1 Sonochemical Synthesis -- 14.2.2 Solvothermal Process -- 14.2.3 Nucleic Acid-mediated Synthesis -- 14.2.4 Synthesis by Ionizing Radiations -- 14.2.5 Biosynthesis."]
[{"$nulls":4},"14.2.6 Precipitation of Salts in an Aqueous Medium."]