{"text_format":"2","workbook":"xls","n_sheets":1,"sheets":["report2"],"not_rendered":{"charts":0,"images":0,"macros":0,"external_links":1,"defined_names":2,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"run_cost":"one","rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"report2","index":0,"n_rows":37,"n_cols":5,"rows_kept":37,"cut":false,"hidden":false,"merged":[[0,2,0,3],[0,4,0,5],[1,2,1,3],[1,4,1,5],[2,2,2,3],[4,2,4,3],[6,2,6,3],[7,2,7,3],[8,2,8,3],[10,2,10,3],[11,2,11,3],[14,2,14,3],[23,2,23,3],[23,4,23,5],[24,2,24,3],[24,4,24,5],[25,2,25,3],[25,4,25,5],[26,2,26,3],[27,2,27,3],[28,2,28,3],[29,2,29,3],[33,2,33,3],[34,2,34,3]],"flags":["formulas_cached_only"]}
[null,"1.","Record Nr.",null,"UNINA9910592989003321"]
[null,null,"Titolo",null,"Spasticity and muscle stiffness : restoring form and function / / Preeti Raghavan, editor"]
[null,null,"Pubbl/distr/stampa",null,"Cham, Switzerland : , : Springer, , [2022]"]
[{"$nulls":4},"©2022"]
[null,null,"ISBN",null,"9783030969004"]
[{"$nulls":4},"9783030968991"]
[null,null,"Descrizione fisica",null,"1 online resource (329 pages)"]
[null,null,"Disciplina",null,"612.74"]
[null,null,"Soggetti",null,"Muscles - Physiology"]
[{"$nulls":4},"Spasticity"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Intro -- Foreword -- Preface -- Contents -- Contributors -- Part I: Pathophysiology and Assessment -- 1: Neural Basis of Spasticity -- Definition of Spasticity -- Time Course of the Development of Spasticity -- What Types of Neural Injury Lead to the Development of Spasticity? -- How Does Injury to the Corticospinal Tract Lead to Spasticity? -- Consequences of Excitatory-Inhibitory Imbalance in Spinal Circuitry -- Conclusion -- References -- 2: Spasticity Versus Spastic Movement Disorder -- Introduction -- Pathophysiology -- Clinical Aspects -- Functional Aspects -- Implications for Treatment -- Conclusion -- References -- 3: Clinical Assessment of the Syndrome of Spastic Paresis -- Introduction -- Assessment of Spasticity -- Ashworth-Derived Scales -- The Tardieu Scale -- The Syndrome of Spastic Paresis -- The Non-Neural Muscle Disorder: Spastic Myopathy -- The Neural Disorder -- Muscle Overactivity in Antagonists -- Stretch-Sensitive Paresis in Agonists -- The Five-Step Assessment -- Functional Step: Step 1 -- Technical Steps: Steps 2-5 -- Conclusion -- References -- 4: Quantitative Measurement of Resistance to Passive Joint Motion in Chronic Stroke Survivors -- Introduction -- Quantification of Neural and Biomechanical Responses During Elbow Joint Rotation -- Determination of Catch Angle and EMG Response -- Occurrence of a Catch -- EMG Onset Angle -- Catch Angle and Reflex EMG Response as a Function of Joint Rotation Speed -- Timing of the Onset of the EMG Response and the Catch Angle -- Origins of the Resistance "]
[{"$nulls":4},"to Passive Joint Motion -- Quantification of the Resistance to Passive Joint Rotation After BoNT Injections in Chronic Stroke Survivors -- Conclusions -- References -- 5: Structural Alterations in Muscle in Children with Spastic Cerebral Palsy -- Skeletal Muscle Structure -- Change in Muscle Structure During Postnatal Development."]
[{"$nulls":4},"Muscle Adaptation -- Clinical Presentation in Children with Cerebral Palsy -- Sarcomere Alterations in Contractured Muscles -- Extracellular Matrix -- Alterations in Extracellular Matrix Content -- Alterations in Passive Muscle Stiffness -- Muscle Stem Cells -- Satellite Cells -- Change in Satellite Cells in Contractured Muscles -- Metabolic Properties -- Alterations in Motor Units and in the Neuromuscular Junction -- Conclusion -- References -- 6: Mechanisms of Development of Passive Mechanical Muscle Stiffness -- Introduction -- Three-dimensional Muscle Geometry and its Effect on Active and Passive Force Generation -- The Architecture of Muscle Affects its Force Generating Capacity -- The ECM Transmits Force Laterally and Facilitates Muscle Shape Changes -- The Three-dimensional Nature of Muscle Contraction -- Effect of Fluid-ECM Interactions on Muscle Mechanics -- Role of Intramuscular Fluid on the Properties of the ECM -- Intramuscular Fluid Affects the Viscosity of the Ground Substance of the ECM -- Muscle Hydration, Lubrication, Viscoelasticity, and ECM Stiffness -- Effect of Exercise, Immobility, and Overuse on Hyaluronan Concentration -- The Hyaluronan Hypothesis of Muscle Stiffness: its Role in Spasticity, Fibrosis, and Contracture -- The Hyaluronan Hypothesis of Muscle Stiffness -- Spasticity Versus Muscle Stiffness -- Role of Hyaluronan in the Progression to Fibrosis and Contracture -- Conclusion -- References -- 7: Symptomatic and Functional After-Effects of the Syndrome of Spastic Paresis -- Introduction -- Functional Consequences in the Upper Limb -- Skin and Nerve Problems -- Skin Problems of the Hand, at the Elbow Crease, and in the Axilla -- Episodic Disruptive Symptoms -- Associated Reactions -- Physical Compression and Injury -- Problems of Access -- Access to the Hand, Fingers, and Thumb -- Access to the Elbow Crease."]
[{"$nulls":4},"Access to the Axilla -- Grasp and Release Dysfunction -- Inadequate Hand Opening Preceding Grasp -- Inadequate Hand Opening During Release -- Hyperextended Wrist and Finger Flexor Tenodesis -- Joint and Muscle Contractures -- The Intrinsic plus Hand -- The Flexed Thumb -- Reach Dysfunction -- Inadequate Scapular Rotation -- Inadequate Shoulder Movement -- Inadequate Elbow Movement -- Inadequate Forearm Orientation of the Hand -- Inadequate Vernier Adjustments of the Wrist -- Functional Consequences in the Lower Limb -- Skin and Footwear Problems -- Striatal Toe -- Painful Toe Flexion -- Problems of Limb Clearance -- Stiff Knee with and without Equinovarus -- Inadequate Hip Flexion -- Problems of Foot Loading -- Loading on the Lateral Border of the Foot -- Forefoot First Loading -- Problems of Limb Advancement -- Insufficient Hip Flexion -- Stiff Knee (Inadequate Knee Flexion in Swing Phase) -- Toe Drag -- Inadequate Knee Extension in Terminal Swing -- Problems of Single Limb Support -- Knee Flexion in Stance -- Weak Knee Extensors -- Painful Toe Flexors During Loading and Weightbearing -- Conclusions -- References -- Part II: Treatment -- 8: Framework for the Treatment of Spasticity and Muscle Stiffness -- Introduction -- Rehabilitation Based on Principles of Motor Learning -- Medical and Pharmacologic Treatment Algorithm -- The Patient's Experience -- Spasticity Versus Muscle Stiffness -- The Five-Step Assessment -- Generalized and Focal Treatments -- Emerging Non-Pharmacologic Treatments -- Conclusion -- References -- 9: Medical Exacerbation of Spasticity -- Introduction "]
[{"$nulls":4},"-- Pathophysiology of Autonomic Dysfunction in Individuals with Spasticity -- Medical Conditions that Exacerbate Spasticity -- The Genitourinary Tract -- The Gastrointestinal System -- Skin Conditions -- Heterotopic Ossification -- Venous Thromboembolism -- Fractures."]
[{"$nulls":4},"Management of Paroxysmal Sympathetic Hyperactivity -- Miscellaneous Causes -- Conclusion -- References -- 10: Oral Spasmolytics -- Introduction -- GABA Agonists/GABA Mimetics -- Baclofen -- Mechanisms of Action -- Clinical Use -- Dosing -- Side Effect Profile -- Benzodiazepines -- Mechanism of Action -- Diazepam -- Dosing -- Side Effect Profile -- Clonazepam -- Dosing -- Side Effect Profile -- Tiagabine -- Mechanism of Action -- Clinical Use -- Dosing -- Side Effect Profile -- Alpha 2 Agonists -- Tizanidine -- Mechanism of Action -- Clinical Use -- Dosing -- Side Effect Profile -- Clonidine -- Mechanism of Action and Clinical Use -- Dosing -- Side Effect Profile -- Dantrolene Sodium -- Mechanism of Action -- Clinical Use -- Dosing -- Side Effect Profile -- Sodium and/or Calcium Channel Blocking Agents -- Mechanism of Action -- Sodium Channel Blocking Agents -- Mechanism of Action -- Clinical Use/Dosing -- Calcium Channel Blocking Agents -- Mechanism of Action -- Clinical Use/Dosing -- Combination of Sodium and Calcium Channel Blocking Agents -- Mechanism of Action -- Clinical Use/Dosing -- Potassium Channel Blocking Agent -- 4-Aminopyridine -- Mechanism of Action -- Clinical Use -- Dosing -- Side Effect Profile -- Serotonergic/Alpha Receptor Antagonist -- Cyproheptadine -- Mechanism of Action -- Clinical Use -- Dosing -- Side Effect Profile -- Cannabis -- Mechanism of Action -- Clinical Use/Dosing -- Side Effect Profile -- Medications with Unknown Mechanism of Action for Muscle Spasms -- Cyclobenzaprine -- Mechanism of Action -- Clinical Use/Dosing -- Side Effect Profile -- Orphenadrine -- Mechanism of Action -- Clinical Use -- Dosing -- Side Effect Profile -- Mexiletine -- Mechanism of Action -- Clinical Use -- Dosing -- Side Effect Profile -- Conclusion -- References -- 11: Intrathecal Baclofen Therapy -- Introduction."]
[{"$nulls":4},"Components of Intrathecal Baclofen Therapy -- Patient Selection -- Patient Characteristics -- Advantages and Disadvantages of Intrathecal Baclofen Therapy -- Intrathecal Baclofen Trial -- Successful Trial -- Skipping a Trial -- Adverse Events During a Trial -- Pump Implantation -- Pump Options -- Initiation of ITB Therapy -- Modes of Dose Delivery -- Dose Titration -- Post-implant Rehabilitation -- Patient and Caregiver Education -- Pump Refill and Therapy Maintenance -- Refill Appointments -- Refill Procedure -- Baclofen Withdrawal -- Baclofen Overdose -- Troubleshooting -- Diagnosis of Pump Catheter Malfunction -- Bolus Dosing -- Residual Volume Mismatch -- Catheter Access Port Aspiration -- Imaging -- Pump Replacement and Explantation -- Conclusion -- References -- 12: Treatment of Focal Muscle Overactivity Using Botulinum Toxin Injections -- Introduction -- Structure -- Mechanism of Action -- Binding -- Internalization -- Translocation -- Cleavage -- Pharmacology -- Review of AAN Guidelines for the Utility of BoNT in Spasticity -- Adult Upper Limb Spasticity -- Adult Lower Limb Spasticity -- Cerebral Palsy -- Emerging Evidence -- Review of Dose Recommendations -- Upper Limb Spasticity -- Lower Limb Spasticity -- Patient and Muscle Selection for Treatment -- The Preinjection Consultation -- Planning the Injection -- Localization of Muscles -- After Injection -- Measuring Outcomes -- Goal Attainment -- Measures of Spasticity -- Caregiver Burden and Quality of Life -- Conclusion -- References -- 13: Treatment of Focal Muscle Stiffness with Hyaluronidase Injections -- Introduction -- Catabolism of Hyaluronan by Hyaluronidases -- Pharmacology and Uses of Exogenous Hyaluronidases -- Novel Off-"]
[{"$nulls":4},"Label Use of Hyaluronidase for Treatment of Muscle Stiffness -- Upper Limb Muscle Stiffness -- Safety and Preliminary Efficacy of a Single Injection Treatment."]
[{"$nulls":4},"Safety and Dose-Response of Multiple Injection Treatments."]
[null,"2.","Record Nr.",null,"UNISALENTO991000137099707536"]
[null,null,"Autore",null,"Walker, Henry J."]
[null,null,"Titolo",null,"Theseus and Athens / Henry J. Walker"]
[null,null,"Pubbl/distr/stampa",null,"New York : Oxford University Press, 1995"]
[null,null,"ISBN",null,"0195089081"]
[null,null,"Descrizione fisica",null,"X, 224 p. ; 25 cm."]
[null,null,"Soggetti",null,"Letteratura greca - Atene - Storia"]
[{"$nulls":4},"Eroi greci"]
[{"$nulls":4},"Mitologia greca - Teseo"]
[{"$nulls":4},"Atene (Grecia) Civiltà"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Contiene bibliografia: pp. 207-215"]