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[null,"1.","Record Nr.",null,"UNINA9910583483703321"]
[null,null,"Autore",null,"Conn P. Michael"]
[null,null,"Titolo",null,"Animal Models for the Study of Human Disease"]
[null,null,"Pubbl/distr/stampa",null,"San Diego : , : Elsevier Science & Technology, , 2017"]
[{"$nulls":4},"©2017"]
[null,null,"ISBN",null,"0-12-809699-3"]
[null,null,"Edizione",null,"[2nd ed.]"]
[null,null,"Descrizione fisica",null,"1 online resource (1200 pages)"]
[null,null,"Disciplina",null,"616.027"]
[{"$nulls":4},"616.0273"]
[null,null,"Soggetti",null,"Disease Models, Animal"]
[{"$nulls":4},"Experimentació animal"]
[{"$nulls":4},"Protecció de la fauna"]
[{"$nulls":4},"Drets dels animals"]
[{"$nulls":4},"Llibres electrònics"]
[{"$nulls":4},"Estats Units d'Amèrica"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,"Nota di contenuto",null,"Cover -- Dedication -- Title Page -- Copyright Page -- Dedication -- Contents -- List of Contributors -- Preface -- Part A - Ethics, resources, and approaches -- Chapter 1 - Ethics in Biomedical Animal Research: The Key Role of the Investigatora -- 1 - Nature and Scope of the Chapter -- 2 - The Subject Matter of Biomedical Animal Research Ethics -- 3 - Why Investigators Should Care About Biomedical Animal Research Ethics -- 3.1 - Investigators are Already Committed to High Ethical Standards -- 3.2 - Ethical Treatment of Animals is Required by Law -- 3.2.1 - General Commitment to Ethical Behavior -- 3.2.2 - Legal Requirements Reflecting General or Specific Ethical Principles -- 3.3 - Ethical Treatment of Animals Promotes Sound Scientific Results -- 3.4 - Ethical Treatment of Animals is Required by Funding Bodies -- 3.5 - Ethical Treatment of Animals is Required by Peer-Reviewed Journals -- 3.5.1 - The ARRIVE Guidelines -- 3.6 - Ethical Treatment of Animals is Essential for Public Support -- 3.7 - Ethical Treatment of Animals is the Right Thing to Do -- 4 - Aspects of Animal Use and Care Relevant to Biomedical Animal Research Ethics -- 5 - Use of Privately Owned Animals in Biomedical Research -- 6 - The Nature of Basic Animal Research -- 6.1 - \"Basic\" Research as the Search for Knowledge "]
[{"$nulls":4},"for its Own Sake -- 6.2 - \"Basic\" Research as the Search for Fundamental, Underlying Mechanisms, and Causes -- 6.3 - What Investigators Mean by \"Basic\" Animal Research -- 6.4 - Recommendations -- 7 - Why Investigators Play the Key Role in Ensuring the Ethical Conduct of Animal Research Projects -- 7.1 - The Nature of Principles of Biomedical Animal Research Ethics -- 7.2 - The Need for Scientific Expertise in Applying General Ethical Principles -- 7.3 - The Investigator as Captain of the Experimental Ship -- 7.3.1 - Primacy of Project Goals."]
[{"$nulls":4},"7.3.2 - Design and Implementation of Experimental Procedures -- 7.3.3 - The Importance of Sound Science in Ensuring Ethical Animal Experimentation -- 7.4 - The Role of Review Committees and Government Officials in Assessing the Ethical Appropriateness of Animal Experiments -- 7.4.1 - Ethical Review in the United States -- 8 - Sources of Guidance for Investigators in Conducting Ethical Research -- 8.1 - Scientific Resources -- 8.2 - Ethical and Ethically Relevant Resources -- 8.2.1 - Legally Mandated Ethical Principles -- 8.2.2 - Nongovernmental Documents Adherence to Which is Required by Law -- 8.2.3 - Publications of Workshops, Study Committees, and Nongovernmental Entities -- 8.2.4 - Ethical Guidelines of Professional Associations -- 9 - Developing Useful Ethical Guidelines -- 10 - Fundamental Principles of biomedical animal Research Ethics -- F1 - The Biomedical Research Principle -- F2 - The Animal Research Principle -- F3 - The Nuremberg Principle -- F4 - The Pain and Distress Minimization Principle -- F4.1 - Ethical Foundations of the Pain and Distress Minimization Principle -- F4.2 - Qualifications to the Pain and Distress Minimization Principle -- Uncertainty Regarding Minimization -- Imprecision in Estimates of Animal Pain or Distress -- F4.3 - The Incompleteness of the Pain and Distress Minimization Principle -- F5 - The Pain and Distress Justification Principle -- F6 - The Harm Justification Principle -- F6.1 - Determining the Value of a Research Project -- Medical Value of the Project -- Scientific Value of the Project -- F6.2 - Determining Whether the Value of a Project Justifies any Pain, Distress, or Other Harms Caused to the Animals -- Assessing the Project's Medical Value -- Assessing the Nature and Extent of Harms to the Animals."]
[{"$nulls":4},"the project's scientific value as the justificatory link between medical value and harms to the animals -- predictability of results and scientific value -- likely limited impact of successful experimental results -- value of unsuccessful projects -- unpredictability of the impact of research results -- F6.3 - Problematic Expressions of the Harm Justification Principle: \"Harm-Benefit Analysis\" -- why the harm justification principle when properly interpreted should not require likely benefits -- problematic responses to the problem for the harm-benefit analysis of basic animal research -- F6.4 - Further Needed Discussion of the Harm Justification Principle -- F7 - The Harm Minimization Principle -- F8 - The General Justification Principle -- F8.1 - Applying the General Justification Principle to Projects That do and Those That do not Cause Animals Harm -- F8.2 - Why Many Projects That do not Harm Animals Will be Easily Justified -- F9 - The 3Rs Principle -- F9.1 - Redefinition of \"Replacement\" -- F9.2 - Redefinition of \"Refinement\" -- F9.3 - The Need for Clarity and Argument -- F10 - The Species-Appropriate Housing Principle -- F10.1 - Definitions of and Ethical Arguments for Research Animal \"Well-Being\" -- Well-Being as Absence of Pain or Distress -- Well-Being as Including Positive Feelings and Experiences -- Questions About Providing Positive Experiences to Research Animals -- F10.2 - Environmental Enrichment -- Differing Definitions of \"Enrichment\" -- Differing Views of the Aims "]
[{"$nulls":4},"of Enrichment -- Potential Effects on Research Results -- F11 - The Appropriate Care Principle -- F12 - The Appreciation Principle -- F13 - The Translation Principle -- 11 - Practical Ethical Guidelines for Investigators -- P1 - Approach all phases and aspects of an animal research project with the aim of making the project ethically as well as ..."]
[{"$nulls":4},"P2 - Appreciate that as the source of the project's scientific goals, you play the key role in determining whether the proj... -- P3 - Keep in mind that the central question in the ethical assessment of a project is whether its value justifies its use a... -- P4 - To be able to make the strongest case for the medical value of the project, always keep up-to-date information and doc... -- P5 - Design the project with the maximum possible scientific value, by framing sound scientific questions that relate to th... -- P6 - If the project has the potential to cause harms to animals, specifically pain or distress, but also any other signific... -- P7 - In designing and conducting the project, take all reasonable steps to minimize any pain or distress that the animals m... -- P8 - Regard your attending veterinarian as a constant source of information and guidance during all stages of the project -- P9 - Collect, read, and regularly consult publications that enunciate or apply ethical principles relevant to your research -- P10 - Although you should follow legal requirements applicable to the project, when such requirements impose only minimum e... -- 12 - Some Current Difficult Issues in Animal Research Ethics -- 12.1 - The Nature and Weight of Harms to be Justified by the Value of Animal Research Projects -- Unpleasant Experiences Other Than Pain and Distress -- Frustration of an Animal's Nature or Telos -- Killing Research Animals -- 12.2 - Ethical Relevance of Species and Species Characteristics -- The IOM Chimpanzee Report -- The Relative Moral Cost View -- Criteria for Ranking Species -- Number of Ranked Categories -- Research Implications of Species Rankings -- 13 - General Suggestions for Investigators -- S1 - Communicate to the public the nature and potential benefits of your research, and the ethical values and standards you..."]
[{"$nulls":4},"S2 - Become familiar with some of the animal research ethics literature -- S3 - Participate in discussions of ethical issues relating to biomedical animal research -- References -- Chapter 2 - Psychological Environmental Enrichment of Animals in Research -- 1 - Introduction -- 2 - Enrichment and Welfare -- 2.1 - Why Enrich? -- 2.2 - Common Abnormal Behaviors Seen in Captivity -- 2.3 - Types of Enrichment -- 2.3.1 - Social Enrichment -- 2.3.2 - Physical Enrichment -- 2.3.3 - Food Enrichment -- 2.3.4 - Sensory Enrichment -- 2.3.5 - Occupational Enrichment -- 3 - Enrichment and Animal Models -- 3.1 - Neuroplasticity and Neurogenesis -- 3.2 - Neurological Disorders -- 3.3 - Affective Disorders -- 3.4 - Obesity -- 3.5 - Cancer -- 4 - Enrichment and Experimental Variability -- 5 - Implementing an Enrichment Plan -- 5.1 - Understand the Natural History of the Species you are Trying to Enrich -- 5.2 - Devise Enrichment Plans With Specific Behavioral Outcomes in Mind -- 5.3 - Do no Harm -- 5.4 - Consider the Costs of the Enrichment -- 5.5 - \"Listen\" to the Animals to Determine Whether They Find the Enrichment Enriching -- 5.6 - Predictability is Important -- 5.7 - Document -- 6 - Example of an Enrichment Plan: Black-Tailed Prairie Dogs (Cynomys ludovicianus) -- 7 - Conclusions -- Acknowledgments -- References -- Further Reading -- Chapter 3 - Large Farm Animal Models of Human Neurobehavioral and Psychiatric Disorders: Methodological and Practical Considera... -- 1 - Animal Models -- 2 - Why Animal Experimental Studies? -- 3 - Animal Models in Biomedical Research -- 4 - Concerns About the "]
[{"$nulls":4},"Translatability of Findings From Animal Experimental Studies -- 5 - Translational Research -- 6 - Choice of Appropriate Animal Model -- 7 - Where in the Process of Modeling Human Diseases and Developing Putative Therapeutics Have Large Animal Models Been Used?."]
[{"$nulls":4},"8 - Which Model Animal Species Are Classified as Large in Scientific Research?."]
[null,null,null,"Sommario/riassunto","Animal Models for the Study of Human Disease, Second Edition, provides needed information on model sharing, animal alternatives, animal ethics and access to databanks of models, bringing together common descriptions of models for busy researchers across biomedical and biological sciences.Offering easily searchable advantages and disadvantages for each animal model and organized by disease topics, this resource aids researchers in finding the best animal model for research in human disease.- Organized by disease orientation for ease of searchability- Provides information on locating resources, animal alternatives, and animal ethics- Covers a broad range of animal models used in research for human disease- Contributed by leading experts across the globe- Expanded coverage of diabetes and neurological diseases"]