{"text_format":"2","workbook":"xls","n_sheets":1,"sheets":["report2"],"not_rendered":{"charts":0,"images":0,"macros":0,"external_links":1,"defined_names":1,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"run_cost":"one","rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"report2","index":0,"n_rows":26,"n_cols":5,"rows_kept":26,"cut":false,"hidden":false,"merged":[[0,2,0,3],[0,4,0,5],[1,2,1,3],[1,4,1,5],[2,2,2,3],[2,4,2,5],[3,2,3,3],[5,2,5,3],[7,2,7,3],[8,2,8,3],[9,2,9,3],[10,2,10,3],[13,2,13,3],[14,2,14,3],[17,2,17,3]],"flags":["formulas_cached_only"]}
[null,"1.","Record Nr.",null,"UNINA9910583374303321"]
[null,null,"Autore",null,"Haines Duane E"]
[null,null,"Titolo",null,"Fundamental Neuroscience for Basic and Clinical Applications E-Book : With STUDENT CONSULT Online Access"]
[null,null,"Pubbl/distr/stampa",null,"Philadelphia : , : Elsevier, , 2017"]
[{"$nulls":4},"©2018"]
[null,null,"ISBN",null,"0-323-51224-0"]
[{"$nulls":4},"0-323-39632-1"]
[null,null,"Edizione",null,"[5th ed.]"]
[null,null,"Descrizione fisica",null,"xi, 516 pages : illustrations, portrait"]
[null,null,"Disciplina",null,"612.8/22"]
[null,null,"Soggetti",null,"Central Nervous System - physiology |0 https://id.nlm.nih.gov/mesh/D002490Q000502"]
[{"$nulls":4},"Neurons"]
[{"$nulls":4},"Neuroimaging - methods |0 https://id.nlm.nih.gov/mesh/D059906Q000379"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Includes index."]
[null,null,"Nota di contenuto",null,"Front Cover -- IFC -- FUNDAMENTAL NEUROSCIENCE for Basic and Clinical Applications -- FUNDAMENTAL NEUROSCIENCE for Basic and Clinical Applications -- Copyright -- Contributors -- Preface -- Acknowledgments -- Contents -- I - ESSENTIAL CONCEPTS -- 1 - Orientation to the Structure and Imaging of the Central Nervous System -- OVERVIEW -- Central, Peripheral, and Visceromotor Nervous Systems -- Neurons -- Reflexes and Pathways -- REGIONS OF THE CENTRAL NERVOUS SYSTEM -- Spinal Cord -- Medulla Oblongata -- Pons and Cerebellum -- Midbrain -- Thalamus -- Cerebral Hemispheres -- FUNCTIONAL SYSTEMS AND REGIONS -- Localizing Signs and Localization -- CONCEPT OF AFFERENT AND EFFERENT -- POSTERIOR (DORSAL), ANTERIOR (VENTRAL), AND OTHER DIRECTIONS IN THE CENTRAL NERVOUS SYSTEM -- SYMPTOM OR SIGN? -- Symptom -- Sign -- CLINICAL IMAGES OF THE BRAIN AND SKULL -- Computed Tomography -- Magnetic Resonance Imaging -- Image Density and Intensity -- Imaging of the Brain and Skull -- Sources and Additional Reading -- 2 - The Cell Biology of Neurons and Glia -- OVERVIEW -- STRUCTURE OF NEURONS -- Dendrites -- Cell Body -- Axons and Axon Terminals -- Axonal Transport -- Axonal Transport as a Research Tool -- CLASSIFICATION OF NEURONS AND GROUPS OF NEURONS -- ELECTRICAL PROPERTIES OF NEURONS -- NEURONS AS INFORMATION "]
[{"$nulls":4},"RECEIVERS -- Sensory Neural Information -- Other Neural Information -- NEURONS AS INFORMATION TRANSMITTERS -- Synapses -- Chemical Synapses -- NEUROTRANSMITTERS -- Disorders of Neurotransmitter Metabolism -- GLIA -- ASTROCYTES -- Structural Support and Response to Injury -- Growth Factors and Cytokines -- Environmental Modulation -- Influence on Neurotransmission -- Regional Heterogeneity -- Astrocytes at the Blood-Brain Barrier -- CONTROL OF LOCAL BLOOD FLOW WITHIN THE CENTRAL NERVOUS SYSTEM -- OLIGODENDROCYTES -- MICROGLIA."]
[{"$nulls":4},"TUMORS OF THE CENTRAL NERVOUS SYSTEM -- Glia-Derived Tumors -- Tumors in Children -- Benign Primary Brain Tumors -- Metastatic Brain Tumors -- SUPPORTING CELLS OF THE PERIPHERAL NERVOUS SYSTEM -- DEGENERATION AND REGENERATION -- Sources and Additional Reading -- 3 - The Electrochemical Basis of Nerve Function -- COMBINED FORCES OF CHEMICAL GRADIENTS AND ELECTRICAL POTENTIALS -- Forces Due to Concentration Gradients -- Electrical Forces -- Membrane Potential -- Fluid Transport: Pumps and Channels -- Ohm's Law and the Equivalent Electrical Circuit of the Neuron -- Pain and a Syndrome of Periodic Paralysis -- Attack by the Immune System: Membrane Attack Complexes and Perforins -- Microbial Attacks: Antibiotics -- GRADED POTENTIALS -- Generator Potentials -- Synaptic Potentials -- Receptor Binding and Channel Gating -- Excitatory and Inhibitory Synaptic Currents -- Calculation of the End Plate Potential by Ohm's Law -- ACTION POTENTIALS IN THE NERVE AND IN THE NEURON -- Compound Action Potentials -- Cable Properties of Nerve Processes -- Nerve Conduction Velocity -- REGENERATIVE POTENTIALS USING A SINGLE ACTIVE CURRENT -- Sodium Channel Activated by Depolarization -- Regeneration -- Repolarization -- Threshold Voltage -- Refractory Period -- Unidirectional Propagation -- Saltatory Conduction -- Gating, Selectivity, and the Structure of the Sodium Channel -- MODIFIERS OF EXCITABILITY -- Accommodation -- Anode Break -- Tetany -- Use-Dependent Block and the Treatment of Epilepsy -- Genetic Defects, Toxins, and Venoms -- Demyelinating Disease -- POTASSIUM AND THE VARIETY OF NEURONAL ACTIVITY -- Repolarizing the Neuron -- Controlling Excitability -- Pacing APs -- NEURONAL ACTIVITY AS INFORMATION -- Sources and Additional Reading -- 4 - Chemical Signaling in the Nervous System -- THE SYNAPSE: ADAPTABLE TO MANY TASKS -- Structure and Function."]
[{"$nulls":4},"Transmitters and Modulators -- Synthesis and Storage -- Release -- Transduction -- Termination -- GLUTAMATE RECEPTORS: THE TETRAMERIC EXCITATORY IONOTROPIC RECEPTORS -- AMPA Receptors and Milliseconds of Excitation -- NMDA Receptors and Seconds of Activation -- Kainate Receptors: AMPA-like, but Presynaptic -- CYS-LOOP RECEPTORS: THE PENTAMERIC MULTIFUNCTIONAL IONOTROPIC RECEPTORS -- Acetylcholine as a Neurotransmitter -- The Nicotinic Acetylcholine Receptor -- Neuromuscular Junction Structure and Transmitter Release -- Synaptic Vesicles: Transmitter Storage and Release -- The Postsynaptic Response and Transmitter Disposal -- Muscle Weakness due to Failure of Transmission at the Neuromuscular Junction -- Tetanus -- The Inhibitory Cys-Loop Receptors -- Serotonin (5-HT) and Emesis -- Cys-Loop Receptors at Targets in Parasites -- G PROTEIN-COUPLED TRANSMITTERS -- Long-Term Potentiation by Phosphorylation -- G Proteins Have Receptors as Exchange Factors -- Glutamate and the G Proteins -- Muscarinic Receptors -- THE BIOGENIC AMINES MODULATE SYNAPTIC ACTIVITY -- Catechol Synthesis and Storage -- Serotonin Synthesis and Functions -- Catechol Release and Reuptake -- Psychotropic Drugs and the Uptake and Delivery of "]
[{"$nulls":4},"Catecholamines -- G Protein Receptors for the Biogenic Amines -- PURINE NEUROTRANSMISSION: SENSATION AND COFFEE TOO -- PEPTIDES MODULATE BRAIN FUNCTION -- RETROGRADE TRANSMISSION -- CODA -- Sources and Additional Reading -- 5 - Development of the Nervous System -- OVERVIEW -- DEVELOPMENT OF THE NEURAL TUBE: GENERAL CONCEPTS -- BRAIN DEVELOPMENT -- Induction -- Primary Neurulation -- Congenital Nervous System Defects of Primary Neurulation -- Secondary Neurulation -- Congenital Nervous System Defects of Secondary Neurulation -- Primary Brain Vesicles -- Secondary Brain Vesicles -- Diencephalon and Cerebral Hemispheres."]
[{"$nulls":4},"Defects of Prosencephalization -- Infectious Diseases Causing Congenital Nervous System Defects -- Ventricular System -- PERIPHERAL NERVOUS SYSTEM -- Neural Crest -- Placodes -- Cranial Nerve Ganglia -- Posterior (Dorsal) Root Ganglia -- Visceral Motor System -- Schwann Cells -- CENTRAL NERVOUS SYSTEM -- Basic Features -- Spinal Cord -- Relationship of Spinal Cord to Vertebral Column -- Brainstem -- Cerebellum -- Thalamus -- Cerebral Cortex -- Abnormalities of Cortical Development -- CELLULAR EVENTS IN BRAIN DEVELOPMENT -- Overproduction of Neurons and Apoptosis -- Axonal Outgrowth -- Synaptogenesis -- Plasticity and Competition -- Myelination -- Sources and Additional Reading -- II - REGIONAL NEUROBIOLOGY -- 6 - The Ventricles, Choroid Plexus, and Cerebrospinal Fluid -- OVERVIEW -- DEVELOPMENT -- Foramina of the Fourth Ventricle -- Formation of the Choroid Plexus -- VENTRICLES -- Lateral Ventricles -- Third Ventricle -- Cerebral Aqueduct -- Fourth Ventricle -- Hemorrhage into the Ventricles -- EPENDYMA, CHOROID PLEXUS, AND CEREBROSPINAL FLUID -- Ependyma -- Ependymomas -- Choroid Plexus -- Tumors of the Choroid Plexus -- Cerebrospinal Fluid in Health and Disease -- Cerebrospinal Fluid Production and Circulation -- HYDROCEPHALUS AND RELATED CONDITIONS -- Obstructive Hydrocephalus -- Aqueductal Stenosis -- Communicating Hydrocephalus -- Hydrocephalus ex Vacuo -- Idiopathic Intracranial Hypertension -- Normal-Pressure Hydrocephalus -- Sources and Additional Reading -- 7 - The Meninges -- OVERVIEW -- DEVELOPMENT OF THE MENINGES -- OVERVIEW OF THE MENINGES -- DURA MATER -- Periosteal and Meningeal Dura -- Dural Border Cell Layer -- Blood Supply -- Nerve Supply -- Dural Infoldings and Sinuses -- Compartments and Herniation Syndromes -- Cranial Versus Spinal Dura -- ARACHNOID MATER -- Arachnoid Barrier Cell Layer."]
[{"$nulls":4},"Arachnoid Trabeculae and the Subarachnoid Space -- Arachnoid Villi -- MENINGIOMA -- Origins and Locations -- General Histologic Features -- Symptoms and Treatment -- MENINGEAL HEMORRHAGES -- Extradural and \"Subdural\" Hemorrhages -- Hygroma -- Pia Mater -- Cisterns, Subarachnoid Hemorrhages, and Meningitis -- Subarachnoid Hemorrhage -- Meningitis -- Sources and Additional Reading -- 8 - A Survey of the Cerebrovascular System -- OVERVIEW -- CAUSES OF VASCULAR COMPROMISE -- Aneurysm -- Cerebral Embolism -- Penumbra -- Arteriovenous Malformation -- INTERNAL CAROTID SYSTEM -- Internal Carotid Artery -- Anterior Cerebral Artery -- Middle Cerebral Artery -- VERTEBROBASILAR SYSTEM -- Vertebral Artery -- Posterior Inferior Cerebellar Artery -- Basilar Artery -- Posterior Cerebral Artery -- CEREBRAL ARTERIES AND WATERSHED INFARCTS -- CIRCLE OF WILLIS -- Central Branches -- VEINS AND VENOUS SINUSES OF THE BRAIN -- Cerebral Hemispheres -- Basal Aspect of the Brain -- Internal Veins of the Hemisphere -- Brainstem and Cerebellum -- Cerebral Venous Thrombosis -- ARTERIES OF THE SPINAL CORD -- VEINS OF THE SPINAL CORD -- Spinal Arteriovenous Malformations -- BLOOD-BRAIN BARRIER -- 9 - The Spinal Cord -- OVERVIEW -- "]
[{"$nulls":4},"DEVELOPMENT -- Neural Plate -- Neural Tube -- Neural Tube Defects -- SPINAL CORD STRUCTURE -- Surface Features -- Spinal Meninges -- White Matter -- Gray Matter -- Blood Supply -- REGIONAL CHARACTERISTICS -- Cervical Levels -- Thoracic Levels -- Lumbar Levels -- Sacral Levels -- SPINAL NERVES -- Contemporary View of the Functional Components of Spinal Nerves -- Sensory Components of the Spinal Nerve -- Neurotransmitters of Primary Sensory Neurons -- Deafferentation Pain and the Posterior (Dorsal) Root Entry Zone Procedure -- Motor Components of the Spinal Nerve -- Neurotransmitters of Spinal Motor Neurons and Myasthenia Gravis -- SPINAL REFLEXES."]
[{"$nulls":4},"Muscle Stretch Reflex."]