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[null,null,"Titolo",null,"Pouchitis and ileal pouch disorders : a multidisciplinary approach for diagnosis and management / / edited by Bo Shen"]
[null,null,"Pubbl/distr/stampa",null,"London, United Kingdom : , : Academic Press, An imprint of Elsevier, , [2019]"]
[{"$nulls":4},"©2019"]
[null,null,"ISBN",null,"0-12-809629-2"]
[null,null,"Descrizione fisica",null,"1 online resource (574 pages)"]
[null,null,"Disciplina",null,"616.35"]
[null,null,"Soggetti",null,"Proctology"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,"Nota di contenuto",null,"Front Cover -- Pouchitis and Ileal Pouch Disorders: A Multidisciplinary Approach for Diagnosis and Management -- Copyright -- Dedication -- Contents -- Contributors -- Author's Biography -- Preface -- Chapter 1 Current Medical Therapies for Ulcerative Colitis -- Introduction -- Assessing Disease Severity and Response to Medical Therapy -- Aminosalicylates -- Oral Preparations -- Rectal Preparations -- Efficacy of ASA -- Corticosteroids -- Systemic Steroids -- Targeted Steroids -- Maintenance Therapy and Adverse Effects -- Antimetabolites -- Thiopurines -- Combination Therapy -- Methotrexate -- Calcineurin Inhibitors -- Intravenous CSA -- Other Formulations of CSA -- Tacrolimus -- Mammalian Target of Rapamycin Inhibitors -- Mycophenolate Motefil -- Monoclonal Antibodies to TNF- α -- Infliximab -- Other TNF Inhibitors -- Anti-integrins -- Vedolizumab -- Natalizumab -- Etrolizumab -- Smoking, Nicotine, and UC -- Induction Therapy -- Maintenance Therapy -- Altering the Microbiome in UC -- Probiotics -- Antibiotics -- Fecal Microbiota Transplantation -- Novel/Experimental Agents -- MAdCAM Inhibitors -- Janus Kinase Inhibitors -- ICAM-1 Inhibitors -- Summary and Recommendations -- References -- Further Reading -- Chapter 2 Indications and Preoperative Medical Management of Ulcerative Colitis Patients Undergoing Pouch Surgery -- Introduction -- Indications for the Ileal Pouch -- Medically Refractory UC -- UC Patients With Medicine-Associated Side Effects -- Colitis-Associated Neoplasia -- Crohn's Colitis -- Indeterminate Colitis -- Familial Adenomatous Polyposis -- Other Indications -- Periopertive Use of Anticoagulation "]
[{"$nulls":4},"-- Periopertive Use of Mesalamines -- Periopertive Use of Corticorticosteroids -- Periopertive Use of Immunomodulators -- Purine Analogs -- Methotrexate -- Cyclosporine A -- Periopertive Use of Antitumor Necrosis Factor Agents."]
[{"$nulls":4},"Periopertive Use of Anti-integrin Agents -- Perioperative Nutrition Support -- Perioperative Blood Transfusion -- Summary and Recommendations -- References -- Chapter 3 Preoperative Evaluation and Techniques of Colectomy and Ileal Pouch Surgery -- Introduction -- Preoperative Evaluation -- Establishing Patient Goals -- Determining Candidacy for IPAA -- Thromboembolic Issues -- Enterostomal Preparation -- Role of the Multidisciplinary IPAA Specialty Team -- Shared Patient Experiences -- Operative Technique of Restorative Proctocolectomy -- Deciding Among Pouch Configurations -- Stapled vs Hand-Sewn (Mucosectomy) Anastomosis -- Alternatives to IPAA -- Summary and Recommendations -- References -- Chapter 4 Risk Factors for Short- and Long-Term Complications of Ileal Pouch Surgery -- Introduction -- Risk Factors for Short-Term (30 Days) Complications -- Anastomotic Leak -- Pelvic Abscess and Sepsis -- Wound Infection -- Risk Factors for Long-Term Surgical Complications -- Pouch-Related Fistula -- Small Bowel Obstruction -- Afferent Limb Syndrome -- Efferent Limb Syndrome -- Non-CD Strictures -- The Leak at the Tip of the \"J\" -- Pouch Prolapse -- Pouch Sinus -- Risk Factors for Pouch Failure -- Patient Factors -- Disease Factors -- Surgical Technique Factors -- Preoperative Factors -- Postoperative Factors -- Summary and Recommendations -- References -- Chapter 5 Stoma, Mucous Fistula, Diverted Large Bowel, and Ileo-Rectal Anastomosis -- Introduction -- End Ileostomy -- Loop Ileostomy -- Complications of Ileostomy and Disease of the Neo-Small Bowel -- Post-colectomy Enteritis -- Stoma Complications -- Peristomal Cutaneous Lesions -- Occurrence of CD of NSI in Patients With Primary or Secondary Stoma After Colectomy -- Mucous Fistula -- Diverted Rectum or Hartmann Pouch -- IRA for UC -- Summary and Recommendations -- Acknowledgment -- Disclosure."]
[{"$nulls":4},"References -- Chapter 6 The Ileal Pouch for Familial Adenomatous Polyposis -- Introduction -- Indications for Surgery -- Timing of Surgery -- Surgical Options and Extent of Resection -- Colectomy and IRA -- TPC and IPAA -- Anal Mucosectomy and Hand-Sewn Anastomosis Versus Double-Stapled IPAA -- Surgical Morbidity and Functional Outcomes -- Surgical Morbidity -- Postoperative Functional Expectations -- QOL After IPAA -- Pouchitis in FAP -- Pouch Strictures -- Postoperative Surveillance After IPAA -- Chemoprevention in FAP -- Special Circumstances: Desmoid Disease and IPAA in FAP -- Summary and Recommendations -- References -- Chapter 7 Ileal Pouch in Children -- Introduction -- Indication for Colectomy in Children -- Technical Aspects of Restorative Proctocolectomy in Children -- Staged Construction of Ileal Pouch -- J- vs S- Pouch -- Mucosectomy vs Without Mucosectomy -- Hand Sewn vs Stapled Anastomoses -- The Pull-Through Techniques -- Comparison of Straight Pull-Through vs J-Pouch Ileoanal Anastomosis -- Open vs Laparoscopic Surgery -- Ileal Pouch for FAP -- Ileal Rectal Anastomosis -- Functional Outcomes of Ileal Pouch in Children -- Risk Factors for Adverse Outcomes of the Pouch -- Risk of Neoplasia of the Pouch -- General Health Maintenance of Pediatric Patients With Pouches -- Summary and Recommendations -- References -- Chapter 8 The Cleveland Classification of Ileal Pouch Disorders -- Introduction -- Surgical and Mechanical Disorders -- Anastomotic or Suture Line Leaks -- Pelvic Sepsis and Pouch Abscess -- Pouch Sinus -- Pouch Fistulae -- Strictures -- Afferent Limb Syndrome -- Efferent Limb Syndrome -- Pouch Prolapse -- Folded "]
[{"$nulls":4},"Pouch and Twisted Pouch -- Floppy Pouch Complex -- Infertility -- Sexual Dysfunction -- Portal and Mesenteric Vein Thrombi -- Other Surgery-Related Disorders of the Pouch -- Inflammatory Disorders -- Pouchitis."]
[{"$nulls":4},"Cuffitis -- CD of the Pouch -- Small Intestinal Bacterial Overgrowth -- Inflammatory Polyps -- Functional Disorders of the Ileal Pouch -- Irritable Pouch Syndrome -- Dyssynergic Defecation -- Dysplasia and Neoplasia -- Metabolic and Systemic Complications -- Anemia -- Bone Loss -- Abnormal Vitamin B12 -- Abnormal Bile Acid Metabolism -- Nephrolithiasis -- Celiac Disease -- Summary and Recommendations -- References -- Chapter 9 Genetic Factors in the Pathogenesis of Inflammatory Pouch Disorders -- Indtroduction -- Experimental Considerations in Pouch Genetic Analyses -- Genetic Associations With Pouch Inflammatory Complications -- Acute Pouchitis -- Chronic Pouchitis and CDL Phenotype -- Alterations in Gene Expression in Pouch Inflammation -- Outcome Prognostication and Risk Management -- Summary and Recommendations -- References -- Chapter 10 Microbiota in Pouchitis and De Novo Crohn's Disease of the Ileal Pouch -- Introduction -- Primary \"Idiopathic\" Pouchitis -- Nonmicrobial Factors Linked to the Development of Idiopathic Pouchitis -- The Gut Microbiota -- Characterization of the Composition of the Gut Microbiota -- Microbial Ecological Diversity -- 16S rRNA Sequencing and Microbial Ecology -- The Application of High-Throughput and Data-Driven Approaches to Microbial Ecology (i.e., \"Omics\") -- Combining \"Omics\" in Systems Biology -- Microbial Taxonomy and Intestinal Disease -- Dysbiosis of the Gut Microbiome, Idiopathic Pouchitis, and a Word of Caution -- Microbial Ecological Changes Follow Stoma Reversal and Restoration of Flow of Enteric Content Into the Ileal Pouch -- Bacterial Diversity Is Altered in the Ileal Pouch -- Cellular Changes Follow Stoma Reversal and Restoration of Flow of Enteric Content Into the Ileal Pouch -- Sulphate Reducing Bacteria and Ideopathic Pouchitis -- Resolution of Idiopathic Pouchitis With Antibiotic Treatment."]
[{"$nulls":4},"Crohn's Disease of the Ileal Pouch -- Diagnosis of Crohn's Disease of the Ileal Pouch -- Etiology and Pathobiological Forms of Crohn's Disease of the Ileal Pouch -- Treatment -- Future Directions in Relation to Idiopathic Pouchitis and Crohn's Disease of the Ileal Pouch -- Summary and Recommendations -- References -- Chapter 11 Pathogenesis of Pouchitis -- Introduction -- Genetical Factors -- Role of Microbiota -- Environmental and Dietary Factors -- Smoking -- Pollution -- Medications -- Dietary Factors -- Pelvic Radiation -- Immunological Factors -- Response to Antiinflammatory Biological Agents -- Pouchitis and Extraintestinal Manifestations (EIM) -- Pouchitis and Other Immune-Mediated Disorders -- Immunogenetics and Immunoserology -- Innate Immunity -- Humoral Immunity -- Adaptive Immunity -- Inflammatory Mediators -- Tissue Ischemia and Hypoxia -- Pouchitis and Surgical Techniques -- Evidence of Tissue Ischemia and Hypoxia From Clinical Therapy -- Thromocytosis and Portal Vein Thrombosis -- Mesentry and Metabolic Factors -- Summary and Recommendations -- References -- Chapter 12 Risk Factors for Chronic Inflammatory Disorders of Ileal Pouch -- Introduction -- Risk Factors for Chronic Pouchitis -- Genetic Factors -- Interleukin-1 Receptor Antagonist Allele 2 -- NOD2/CARD15 -- Toll-Like Receptors -- TNF Allele 2 -- Primary Sclerosing Cholangitis -- Other EIMs -- Extensive Colitis and Backwash Ileitis -- Male Gender -- Young Age at UC Diagnosis or Surgery -- Nonsmoking Status -- Autoimmune Disorders -- Preoperative Use of Corticosteroids -- Preoperative Thrombocytosis -- Type of Ileal Pouch -- Postoperative Use of NSAIDs "]
[{"$nulls":4},"-- Serological Abnormalities -- Risk Factors for CD of the Pouch -- Family History of CD -- Preoperative Diagnosis of IC -- Smoking -- Young Age at Diagnosis or Long Duration of Having an Ileal Pouch -- Ethnicity."]
[{"$nulls":4},"The Absence of PSC."]