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[null,"1.","Record Nr.",null,"UNINA9910583035003321"]
[null,null,"Autore",null,"Postigo Al"]
[null,null,"Titolo",null,"Late-stage fluorination of bioactive molecules and biologically-relevant substrates / / Al Postigo"]
[null,null,"Pubbl/distr/stampa",null,"Amsterdam, Netherlands ; ; Oxford, England ; ; Cambridge, England : , : Elsevier, , 2019"]
[null,null,"ISBN",null,"0-12-813039-3"]
[null,null,"Descrizione fisica",null,"1 online resource (498 pages) : illustrations"]
[null,null,"Disciplina",null,"547.2"]
[null,null,"Soggetti",null,"Fluorination"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Sommario/riassunto","Late-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates reviews how the use of these techniques on compounds with already known and relevant biological activity can provide new pharmaceutical leads with improved medicinal properties. The fluorination strategies discussed take into account both conventional and novel reagents, including nucleophilic, electrophilic, those of a radical nature, and diverse families of organic compounds, such as (hetero) aromatic rings and aliphatic substrates. Drawing on the authors' expert knowledge, this book provides researchers with a broad set of applicable methods to use in their work. Highlights the latest developments in the field in a concise volume. Provides details of key fluorinating reagents across diverse families of organic compounds. Explores the current applications and future potential of fluorine in drug development."]