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[null,"1.","Record Nr.",null,"UNINA990007486150403321"]
[null,null,"Autore",null,"Laberenne, Paul"]
[null,null,"Titolo",null,"L'origine des Mondes / Paul Labérenne"]
[null,null,"Pubbl/distr/stampa",null,"Paris : éd. Hier et aujourd'hui, 1947"]
[null,null,"Descrizione fisica",null,"350 p. : ill. ; 18 cm"]
[null,null,"Locazione",null,"ILFGE"]
[null,null,"Collocazione",null,"A-02-025"]
[null,null,"Lingua di pubblicazione",null,"Francese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,"2.","Record Nr.",null,"UNINA9910574871803321"]
[null,null,"Autore",null,"López R David Augusto"]
[null,null,"Titolo",null,"Estudios de la tuberculosis desde la sucursal del cielo / / Luisa María Nieto Ramirez, editora científica"]
[null,null,"Pubbl/distr/stampa",null,"Colombia, : Universidad Santiago de Cali, 2020"]
[{"$nulls":4},"Cali : , : Editorial Universidad Icesi : , : Editorial Universidad Santiago de Cali, , 2021"]
[null,null,"ISBN",null,"9786287501669"]
[null,null,"Edizione",null,"[Primera edición.]"]
[null,null,"Descrizione fisica",null,"1 online resource : illustrations"]
[null,null,"Disciplina",null,"616.995"]
[null,null,"Soggetti",null,"Tuberculosis - Research - Colombia - Cali"]
[{"$nulls":4},"Respiratory organs - Diseases - Research - Colombia - Cali"]
[{"$nulls":4},"Libros electrónicos."]
[null,null,"Lingua di pubblicazione",null,"Spagnolo"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Nota di bibliografia","Includes bibliographical references."]
[null,null,null,"Sommario/riassunto","Hasta finales del siglo XIX la única alternativa para el diagnóstico de tuberculosis (TB) eran las aproximaciones clínicas. Posteriormente, Koch sentó las bases del diagnóstico microbiológico de TB: microscopía y cultivo de Mycobacterium tuberculosis (Mtb), tecnicas que siguen siendo hoy la base del diagnóstico rutinario de TB en muchos países. El cultivo de Mtb es el estándar de oro de diagnóstico y seguimiento al tratamiento de TB, bien sea cultivo sólido (Lowenstein-Jensen, Ogawa o 7H11) o cultivo líquido (MGIT960, Proskauer-Beck, 7H9, entre otros). El advenimiento de metodologías moleculares llevó al desarrollo del GeneXpert MTB/RIF (amplificación de rpoB para identificar Mtb y resistencia a rifampicina, directo del esputo). Otros metodos moleculares incluyen: LAMP-TB: amplificación isotermica de IS6110 y gyrB, LPA: detección de resistencia a medicamentos de primera y segunda línea con sondas de ADN en tiras de nitrocelulosa. El reto impuesto por el diagnóstico de pacientes coinfectados TB/VIH llevó al desarrollo de LAM-TB. Este último detecta Lipoarabinomanano en la orina de individuos severamente comprometidos con VIH-SIDA. Actualmente, la búsqueda de biomarcadores en suero y orina representa una alternativa prometedora. Se vienen buscando metabolitos, microARNs y proteínas derivadas tanto de Mtb como del huesped humano. La aplicación de ciencias \"omicas\" en las últimas "]
[{"$nulls":4},"decadas ha sido determinante para la búsqueda de nuevos biomarcadores de diagnóstico y pronóstico."]
[{"$nulls":4},"Until the end of the 19th century, the diagnosis of tuberculosis (TB) rested solely on clinical approaches. Subsequently, Koch laid the foundations of the microbiological diagnosis of TB: microscopy and culture of Mycobacterium tuberculosis (Mtb). Today, these techniques remain as the basis for routine TB diagnosis in many countries. In fact, culturing Mtb is the gold standard for both diagnosis and TB treatment follow-up, either in solid (Lowenstein-Jensen, Ogawa, 7H11) or liquid culture systems (MGIT960, Proskauer-Beck, 7H9, among others). The advent of molecular methodologies led to the development of GeneXpert MTB/RIF (amplification of rpoB to identify Mtb and resistance to rifampicin, directly from sputum samples). Other molecular methods include LAMP-TB: isothermal amplification of IS6110 and gyrB, LPA: detection of resistance to first- and second-line drugs using DNA probes in nitrocellulose strips. The challenge imposed by the diagnosis of co-infected TB/HIV patients led to the development of LAM-TB. The latter method is based on the detection of Lipoarabinomannan in the urine of severely immunocompromised individuals with HIV-AIDS. Currently, the search for biomarkers in serum and urine represents a promising alternative. Metabolites, microRNAs and proteins derived from both Mtb and the human host have been also sought. In the last decades, the application of \"omics\" sciences has been decisive for the search of new TB biomarkers for diagnosis and prognosis."]