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[null,"1.","Record Nr.",null,"UNINA9910555004303321"]
[null,null,"Titolo",null,"Axially chiral compounds : asymmetric synthesis and applications / / edited by Bin Tan"]
[null,null,"Pubbl/distr/stampa",null,"Weinheim, Germany : , : WILEY-VCH GmbH, , [2021]"]
[{"$nulls":4},"℗♭2021"]
[null,null,"ISBN",null,"3-527-82518-5"]
[{"$nulls":4},"3-527-82517-7"]
[{"$nulls":4},"3-527-82516-9"]
[null,null,"Descrizione fisica",null,"1 online resource (339 pages)"]
[null,null,"Disciplina",null,"547.2"]
[null,null,"Soggetti",null,"Asymmetric synthesis"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,"Nota di contenuto",null,"Cover -- Title Page -- Contents -- Preface -- Part I Asymmetric Synthesis -- 1 Introduction and Characteristics -- 1.1 Introduction and Classification -- 1.2 Specification of Configuration -- References -- 2 Metal-Catalyzed Asymmetric Synthesis of Biaryl Atropisomers -- 2.1 Introduction -- 2.2 Biaryl Coupling -- 2.2.1 Cross-coupling -- 2.2.2 Other Types of Cross-coupling -- 2.2.3 Oxidative Coupling -- 2.3 Desymmetrization and (Dynamic) Kinetic Resolution via Functional Group Transformation -- 2.3.1 Desymmetrization of Prochiral Biaryls -- 2.3.2 Kinetic Resolution of Racemic Axially Chiral Biaryls -- 2.3.3 Dynamic Kinetic Resolution of Racemic Axially Chiral Biaryls -- 2.3.4 Ring-opening Reactions -- 2.4 Formation of Aromatic Ring via [2 + 2 + 2] Cycloaddition -- 2.4.1 Cobalt-Catalyzed Enantioselective [2 + 2 + 2] Cycloadditions -- 2.4.2 Rhodium-Catalyzed Enantioselective [2 + 2 + 2] Cycloadditions -- 2.4.3 Iridium-Catalyzed Enantioselective [2 + 2 + 2] Cycloadditions -- 2.5 CH Bond Functionalization -- 2.5.1 Chiral Catalyst-Controlled CH Bond Functionalization -- 2.5.2 Chiral Auxiliary-Induced CH Bond Functionalization -- 2.5.3 Atroposelective CH Arylation -- 2.6 Summary and Conclusions -- References -- 3 Organocatalytic Asymmetric Synthesis of Biaryl Atropisomers -- 3.1 Introduction -- 3.2 Atroposelective Synthesis of Biaryls by Kinetic Resolution Strategy -- 3.2.1 Conventional Kinetic Resolution -- 3.2.2 Dynamic Kinetic Resolution Strategy -- 3.3 Atroposelective Synthesis of Biaryls by Desymmetrization Strategy -- 3.4 Atroposelective Arene "]
[{"$nulls":4},"Formation to Access Axially Chiral Biaryls -- 3.4.1 Intramolecular Atroposelective Arene Formation -- 3.4.2 Atroposelective Arene Formation via Intermolecular Annulation -- 3.5 Atroposelective Synthesis of Biaryls via Direct C-H Arylation Strategy."]
[{"$nulls":4},"3.5.1 Organocatalytic C-H Arylation by [3,3]-Sigmatropic Rearrangement -- 3.5.2 Atroposelective Arylation Based on Quinone Derivatives -- 3.5.3 Atroposelective Nucleophilic Aromatic Substitution -- 3.6 Conclusion -- References -- 4 Enantioselective Synthesis of Heterobiaryl Atropisomers -- 4.1 Introduction -- 4.2 Atropisomeric Heterobiaryls Featuring Two Six-Membered Rings -- 4.2.1 Functionalization of Heterobiaryls -- 4.2.2 Atroposelective Ring Formation -- 4.3 Atropisomeric Heterobiaryls Featuring a Five-Membered Ring -- 4.3.1 From Preformed Cyclic Systems -- 4.3.2 Formation of the Heterobiaryl Axis -- 4.3.3 Atroposelective Ring Formations -- 4.4 Atropisomeric Heterobiaryls Featuring Two Five-Membered Rings -- 4.4.1 Functionalization of Heterobiaryls -- 4.4.2 Aromatization of a Bis-heterocycle -- 4.4.3 Atroposelective Ring Formations -- 4.5 Conclusion and Outlook -- References -- 5 Asymmetric Synthesis of Nonbiaryl Atropisomers -- 5.1 Introduction -- 5.2 Styrenes -- 5.2.1 Axially Chiral Styrenes via Point-to-Axial Chirality Transfer -- 5.2.2 Axially Chiral Styrenes Controlled by Chiral Auxiliary -- 5.2.3 Metal-Catalyzed Enantioselective Synthesis of Axially Chiral Styrene -- 5.2.4 Organocatalytic Synthesis of Axially Chiral Styrenes -- 5.3 Amides -- 5.3.1 Stereochemical Stability of Atropisomeric Amides -- 5.3.2 Lithiation of Atropisomeric Amides to Access Various Alkylations -- 5.3.3 Syntheses of Atropisomerically Stable Amides via Chiral Auxiliaries -- 5.3.4 Catalytic Asymmetric Dihydroxylation via Sharpless KR Conditions -- 5.3.5 Atroposelective Aldol Reactions via DKR Approach -- 5.3.6 Atroposelective Halogenation of Aromatic Amides -- 5.3.7 Atroposelective [2 + 2 + 2] Cycloaddition Toward Atropisomerically Stable Benzamides -- 5.3.8 Enantioselective O-alkylation of Axially Chiral Amides -- 5.4 Diaryl Ethers."]
[{"$nulls":4},"5.4.1 Resolution Studies of Diaryl Ethers -- 5.4.2 Enantioselective Synthesis of Diaryl Ether -- 5.4.3 Enzyme-Catalyzed Synthesis of Diaryl Ether -- 5.4.4 Synthesis of Scaffolds Related to Diaryl Ethers via Csp2-H Activation -- 5.5 Anilides -- 5.5.1 Stereochemical Stability of Axially Chiral Anilides -- 5.5.2 Kinetic Resolution or DKR to Access Axially Chiral Anilides -- 5.5.3 Synthesis of Axially Chiral Anilides via Planar to Axial Chirality Transfer -- 5.5.4 Metal-Catalyzed Synthesis of Chiral Anilides -- 5.5.5 Organocatalytic Synthesis of Chiral Anilides -- 5.6 Lactams and Related Scaffolds -- 5.6.1 Stereochemical Stability of Atropisomeric Lactams -- 5.6.2 Diastereoselective Cyclization Toward Atropisomeric Lactams -- 5.6.3 Enantioselective N-arylation Toward Lactam Atropisomers -- 5.6.4 Atroposelective [2 + 2 + 2] Cycloaddition with Isocyanates -- 5.6.5 Chiral Auxiliary Approach Toward Resolving Atropisomeric Lactams -- 5.6.6 Enantioselective Brønsted Base-Catalyzed Tandem Isomerization-Michael Reactions Toward Atropisomeric Lactams -- 5.7 Diaryl Amines -- 5.7.1 Stereochemical Stability of Diaryl Amines -- 5.7.2 Atroposelective Approaches Toward Diaryl Amines or Related Scaffolds -- References -- 6 Asymmetric Synthesis of Chiral Allenes -- 6.1 Introduction -- 6.2 Substrate- and Reagent-Controlled Chiral Allenes Synthesis: Stoichiometric Asymmetric Reactions -- 6.2.1 Chirality Transfer -- 6.2.2 Asymmetric Reaction with Stoichiometric Chiral Reagents -- 6.3 Catalytic Asymmetric Strategies for the Syntheses of Chiral Allenes -- 6.3.1 Catalytic Enantioselective Synthesis from Achiral Substances -- 6.3.2 Enantioselective Allene Synthesis from Chiral Substrates -- 6.4 Conclusion and Perspective -- References -- 7 Asymmetric Synthesis "]
[{"$nulls":4},"of Axially Chiral Natural Products -- 7.1 Introduction."]
[{"$nulls":4},"7.2 Diastereoselective Coupling-Point to Axial Chirality Transfer -- 7.2.1 Intramolecular Diastereoselective Coupling -- 7.2.2 Intermolecular Diastereoselective Aryl Coupling -- 7.3 Atroposelective Aryl Coupling with Chiral Catalyst -- 7.3.1 Catalytic Oxidative Aryl Coupling -- 7.3.2 Transition Metal-Catalyzed Atroposelective Aryl Coupling -- 7.4 Asymmetric Transformation of Biaryls -- 7.4.1 Dynamic Kinetic Resolution of Biaryl Structure - The Lactone Method -- 7.4.2 Desymmetrization of Prostereogenic Biaryls -- 7.4.3 Catalytic Atroposelective C-H Functionalization of Biaryls -- 7.4.4 Diastereoselective Synthesis from Racemic Biaryls -- 7.5 Atroposelective Aromatization -- 7.6 Diastereoselective Macrocyclization -- 7.7 Conclusions and Perspectives -- References -- Part II Applications -- 8 Asymmetric Transformations -- 8.1 Asymmetric Transformation of Axially Chiral Biaryls and Heterobiaryls -- 8.1.1 Asymmetric Transformations with Preservation of Axially Chiral Backbone -- 8.1.2 Asymmetric Transformations with Axial-to-central Chirality Transfer -- 8.2 Asymmetric Transformation of Axially Chiral Non-biaryl Compounds -- 8.2.1 Cycloadditions and Cyclizations -- 8.2.2 Reaction with Nucleophiles -- 8.2.3 Reaction with Electrophiles -- 8.2.4 Photoreactions -- 8.3 Asymmetric Transformation of Chiral Allenes -- 8.3.1 Cyclization -- 8.3.2 Cycloaddition -- 8.3.3 Reaction with Nucleophiles -- 8.3.4 Chiral Allene as Nucleophiles -- 8.4 Conclusion -- References -- 9 Application for Axially Chiral Ligands -- 9.1 Introduction -- 9.2 Monodentate Phosphines -- 9.2.1 Asymmetric Hydrogenations -- 9.2.2 Asymmetric Hydrosilylation of Olefins -- 9.2.3 Asymmetric Allylic Substitutions -- 9.2.4 Miscellaneous Catalytic Asymmetric Transformations -- 9.3 Diphosphine Ligands -- 9.3.1 Hydrogenation Reactions -- 9.3.2 CC Bond Formation -- 9.3.3 CX Bond Formation."]
[{"$nulls":4},"9.4 Phosphoramidite and Phosphamide Ligands -- 9.4.1 Asymmetric Conjugate Addition with Organometallic Nucleophiles -- 9.4.2 Hydrogenation -- 9.4.3 Hydroboration/Hydrosilylation Reactions -- 9.4.4 Allylic Substitutions -- 9.4.5 Other Asymmetric Transformations -- 9.5 N-P Ligands -- 9.5.1 Applications of N, P-Ligands -- 9.6 C2-Symmetric Diols -- 9.6.1 Mukaiyama Aldol Condensation Reactions -- 9.6.2 Diels-Alder Reaction -- 9.6.3 Arrangement Reaction -- 9.6.4 Reductive Reactions -- 9.7 Other Axially Chiral Ligands in Asymmetric Transformations -- 9.8 Conclusions -- References -- 10 Application for Axially Chiral Organocatalysts -- 10.1 Introduction -- 10.2 Chiral Brønsted Acid Catalysts -- 10.2.1 Chiral BINOL Derivatives -- 10.2.2 Chiral Phosphoric Acid -- 10.3 Chiral Counteranion Catalysts and Chiral Phase Transfer Catalysts -- 10.4 Brønsted Base Catalyst -- 10.5 Lewis Base Catalysts -- References -- 11 Application in Drugs and Materials -- 11.1 Drugs -- 11.2 Chiral Recognition -- 11.3 Chiral Additives in Liquid Crystals -- References -- Index -- EULA."]
[null,"2.","Record Nr.",null,"UNISALENTO991003490069707536"]
[null,null,"Autore",null,"Fulvi Cittadini, Maria"]
[null,null,"Titolo",null,"L'ivresse di Rabelais / Maria Fulvi Cittadini"]
[null,null,"Pubbl/distr/stampa",null,"Urbino : Argalia, stampa 1983"]
[null,null,"Descrizione fisica",null,"115 p. ; 22 cm"]
[null,null,"Collana",null,"Letteratura e critica"]
[null,null,"Disciplina",null,"843.3"]
[null,null,"Soggetti",null,"Rabelais, François"]
[{"$nulls":4},"Rabelais, François"]
[null,null,"Lingua di pubblicazione",null,"Italiano"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,"3.","Record Nr.",null,"UNINA9910557741603321"]
[null,null,"Autore",null,"Mulatero Paolo"]
[null,null,"Titolo",null,"Role of Genomics in the Management of Hypertension"]
[null,null,"Pubbl/distr/stampa",null,"Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020"]
[null,null,"Descrizione fisica",null,"1 online resource (200 p.)"]
[null,null,"Soggetti",null,"Biology, life sciences"]
[{"$nulls":4},"Research & information: general"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Sommario/riassunto","Arterial hypertension affects about 1 billion people worldwide and it is the strongest modifiable risk factor for cardiovascular disease and related disability. Since the initial discovery of rare monogenic disorders with large effects, the role of genomics has evolved into large genome-wide association studies detecting common variants with a modest effect size. Similarly, pharmacogenomics has emerged as a new tool for understanding variability in drug response, to maximize efficacy and reduce toxicity. This book presents the most recent advances in the field of genetics and genomics of arterial hypertension and their potential impact on clinical management. The book is a useful tool for clinicians but also to the research community and those who want to be updated in the field."]