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[null,"1.","Record Nr.",null,"UNINA9910463883403321"]
[null,null,"Autore",null,"Mayer Russell K. <1966->"]
[null,null,"Titolo",null,"Taking action on internet gambling : federal policymaking 1995-2011 / / Russell K. Mayer"]
[null,null,"Pubbl/distr/stampa",null,"Lanham, Maryland ; ; Plymouth, England : , : Lexington Books, , 2014"]
[{"$nulls":4},"©2014"]
[null,null,"ISBN",null,"0-7391-8066-5"]
[null,null,"Descrizione fisica",null,"1 online resource (175 p.)"]
[null,null,"Disciplina",null,"795.0285/4678"]
[null,null,"Soggetti",null,"Internet gambling - Government policy - United States"]
[{"$nulls":4},"Internet gambling - Law and legislation - United States"]
[{"$nulls":4},"Electronic books."]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Contents; List of Figures; List of Tables; Preface; Chapter One: State and Federal Regulation of Gambling; Chapter Two: Constitutional Guidance, Constraint, and Interpretation; Chapter Three: Media Messages and Back Burner Bias; Chapter Four: Public Opinion on Internet Gambling; Chapter Five: A Decade of Debate and a Decision in a Day; Chapter Six: Interest Group Influence; Chapter Seven: Laying Down the Law; Chapter Eight: The Courts Weigh In; Chapter Nine: The Causes and Consequences of Constraint, Momentum, and Discretion; Bibliography; Index; About the Author"]
[null,null,null,"Sommario/riassunto","In Taking Action on Internet Gambling, Russel K. Mayer uses the rise and fall of the Internet gambling industry to illustrate a new and comprehensive approach to understanding how public policy is made in the United States. Through an evidence-based argument, Mayer advances the CMD theory, which puts forth that different phases of policy are governed by three distinct political dynamics: constraint, momentum, and discretion."]
[null,"2.","Record Nr.",null,"UNINA9910557615903321"]
[null,null,"Autore",null,"Aliño Salvador"]
[null,null,"Titolo",null,"Oligonucleotide, Therapy, and Applications"]
[null,null,"Pubbl/distr/stampa",null,"Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022"]
[null,null,"Descrizione fisica",null,"1 online resource (123 p.)"]
[null,null,"Soggetti",null,"Medicine"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Sommario/riassunto","Oligonucleotides (ON) constitute a new group of molecular agents, the object of significant interest due to their potential value as drugs for diagnostic and therapeutic applications. Their special interest derives from the intrinsic characteristics of ONs: a) ONs are informative agents, a property that derives from the order in which the nucleotides of each particular ON are arranged; b) ONs can act as ligands (ASO, TFO, aptamers, G-quadruplex, etc.) of complementary nucleic acid sequences (DNA or RNA) due to their high capacity to hybridize (by means of Watson and Crick or Hoogsteen links) with other nucleotide sequences, resulting in specific gene modulatory effects. However, nonspecific sequences may also be of interest, as is the case with repetitive nucleotide sequences (CpG) with adjuvant effects of vaccines; c) ONs can also rapidly evolve to achieve specific advantages of utility (targeting, stability, efficacy, toxicity, etc.) or high-sensitivity diagnostic technology (markers, analyzes, biosensors, FISH, microarrays, etc.), by chemical modification of nucleotides in any of their atoms. These properties show that ONs are first-order molecules due to their potential usefulness in practice.In this collection of research articles and review papers, we aim to highlight their therapeutic, but also diagnostic and technological utility as drugs."]