{"text_format":"2","workbook":"xls","n_sheets":1,"sheets":["report2"],"not_rendered":{"charts":0,"images":0,"macros":0,"external_links":1,"defined_names":3,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"run_cost":"one","rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"report2","index":0,"n_rows":55,"n_cols":5,"rows_kept":55,"cut":false,"hidden":false,"merged":[[0,2,0,3],[0,4,0,5],[1,2,1,3],[1,4,1,5],[2,2,2,3],[2,4,2,5],[3,2,3,3],[4,2,4,3],[8,2,8,3],[9,2,9,3],[11,2,11,3],[15,2,15,3],[16,2,16,3],[20,2,20,3],[28,2,28,3],[28,4,28,5],[29,2,29,3],[29,4,29,5],[30,2,30,3],[30,4,30,5],[31,2,31,3],[33,2,33,3],[34,2,34,3],[35,2,35,3],[36,2,36,3],[38,2,38,3],[39,2,39,3],[42,2,42,3],[45,2,45,3],[45,4,45,5],[46,2,46,3],[46,4,46,5],[47,2,47,3],[47,4,47,5],[48,2,48,3],[49,2,49,3],[50,2,50,3],[51,2,51,3],[52,2,52,3]],"flags":["formulas_cached_only"]}
[null,"1.","Record Nr.",null,"UNINA9910146241603321"]
[null,null,"Autore",null,"Sytkowski Arthur J"]
[null,null,"Titolo",null,"Erythropoietin [[electronic resource] ] : blood, brain and beyond / / Arthur J. Sytkowski"]
[null,null,"Pubbl/distr/stampa",null,"Weinheim, : Wiley-VCH, 2004"]
[null,null,"ISBN",null,"1-280-52052-3"]
[{"$nulls":4},"9786610520527"]
[{"$nulls":4},"3-527-60543-6"]
[{"$nulls":4},"3-527-60238-0"]
[null,null,"Descrizione fisica",null,"1 online resource (240 p.)"]
[null,null,"Disciplina",null,"612.111"]
[{"$nulls":4},"615.39"]
[null,null,"Soggetti",null,"Erythropoietin"]
[{"$nulls":4},"Erythropoietin - Physiological effect"]
[{"$nulls":4},"Erythropoietin - Therapeutic use"]
[{"$nulls":4},"Electronic books."]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Erythropoietin; Preface; Contents; 1 Introduction and History; 1.1 Early Observations; 1.2 Carnot and Deflandre: A Humoral Factor that Stimulates Erythropoiesis; 1.3 Reissmann, Erslev, Jacobson and Stohlman: The Kidney as the Likely Source; 1.4 More Evidence for the Kidney . . . Erythrogenin?; 1.5 Early Assays for Erythropoietin; 1.6 Standardization: What is a \"Unit\" of Erythropoietin?; 1.7 References; 2 Developmental Biology of Erythropoiesis and Erythropoietin Production; 2.1 Introduction; 2.2 Yolk Sac Hematopoiesis; 2.2.1 The Role of Erythropoietin in Yolk Sac Erythropoiesis"]
[{"$nulls":4},"2.2.2 Genes Essential to Primitive Erythropoiesis2.3 Fetal Liver and Bone Marrow (Definitive) Erythropoiesis; 2.4 Genes Essential for Definitive Erythropoiesis; 2.5 Erythropoietin Production; 2.6 References; 3 Regulation of the Erythropoietin Gene: A Paradigm for Hypoxia-dependent Genes; 3.1 The Structure of the Erythropoietin Gene; 3.2 Tissue-specific Expression; 3.3 Mechanism of Hypoxic Regulation - Identification of Transcription Factors and Other Regulatory Proteins; 3.3.1 Is the Oxygen Sensor a Heme Protein?"]
[{"$nulls":4},"3.3.2 The 3 ́ Flanking Region of the Erythropoietin Gene Contains Important Regulatory Sequences3.3.3 Identification of the Hypoxia-"]
[{"$nulls":4},"inducible Factor - Hypoxia Regulates More Than the Erythropoietin Gene; 3.3.4 Other Interacting Proteins and the Regulation of HIF-1; 3.3.5 The von Hippel-Lindau Protein, Proline Hydroxylation and the Oxygen Sensor; 3.3.6 Modulation of HIF-1 Activity by Other Signals; 3.3.7 A Final Word on the Heme Protein Hypothesis; 3.4 References; 4 Physiology and Metabolism of Erythropoietin; 4.1 The Kidney as the Site of Production"]
[{"$nulls":4},"4.2 The Liver as a Site of Erythropoietin Production4.3 Erythropoietin Produced in the Bone Marrow; 4.4 Metabolism and Clearance of Erythropoietin; 4.5 Erythropoietin and the Maternal/Fetal Circulation; 4.6 References; 5 Biochemistry and Protein Structure; 5.1 Naturally Occurring Epo; 5.1.1 Difficulties in Purifying the Hormone; 5.1.2 The Purification of Human Urinary Epo; 5.1.3 Biochemical Properties of Human Urinary Epo; 5.1.4 Some Biochemical Properties of Human Serum Epo; 5.2 Recombinant Human Epo; 5.2.1 Cloning the Human Epo Gene; 5.2.2 Glycosylation of Epo"]
[{"$nulls":4},"5.2.3 Physicochemical Properties of Epo5.3 Structure-activity Relationships; 5.3.1 Antibody Studies; 5.3.2 Mutagenesis Studies; 5.4 The Tertiary Structure of Epo; 5.5 References; 6 Receptor Biology and Signal Transduction; 6.1 Receptor Biology; 6.1.1 Identification of the Erythropoietin Receptor; 6.1.2 The Erythropoietin Receptor Gene; 6.1.3 The Structure of the Erythropoietin Receptor: A Member of the Cytokine Receptor Superfamily; 6.1.4 The Extracellular Portion of the Erythropoietin Receptor; 6.1.5 The Cytoplasmic Portion of the Erythropoietin Receptor; 6.2 Signal Transduction Pathways"]
[{"$nulls":4},"6.2.1 Phosphorylation of the Erythropoietin Receptor"]
[null,null,null,"Sommario/riassunto","The use of Epo in medical practice is increasing constantly. It has revolutionized how we think of blood transfusion in medicine and surgery. Moreover, it has become widely known to scientists, physicians, biotech and pharmaceutical executives and the general public. Additionally, the past ten years have seen important advances in our knowledge and understanding of its action both within and outside of the hematopoietic system. Until now, there has been no single source that contains up-to-date information on Epo addressing the array of subjects that this book presents. The boo"]
[null,"2.","Record Nr.",null,"UNINA9910822441203321"]
[null,null,"Autore",null,"Beverly Harlan T. <1976->"]
[null,null,"Titolo",null,"Navigating your way to startup success / / Harlan T Beverly"]
[null,null,"Pubbl/distr/stampa",null,"Berlin, [Germany] ; ; Boston, [Massachusetts] : , : De G Press, , 2018"]
[{"$nulls":4},"©2018"]
[null,null,"ISBN",null,"1-5015-0701-X"]
[null,null,"Descrizione fisica",null,"1 online resource (306 pages) : illustrations, tables"]
[null,null,"Disciplina",null,"658.11"]
[null,null,"Soggetti",null,"Success in business"]
[{"$nulls":4},"New business enterprises"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Includes index."]
[null,null,"Nota di contenuto",null,"Frontmatter -- Acknowledgments -- About the Author -- Contents -- Chapter 1. Introduction-Why do you want to launch a startup, anyway? -- Chapter 2. Failing to Start-What's stopping you? -- Chapter 3. Your Idea Sucks-How would you know? -- Chapter 4. Failing to Ship-Again, what's stopping you? -- Chapter 5. Nobody Cares-What can you do about it? -- Chapter 6. Somebody Cares-Yippee! Now what? -- Chapter 7. Oops, We Ran Out of Money-Funding and finance -- Chapter 8. I Got Sued-It can happen to you -- Chapter 9. Help, I'm Sinking-Controlling growth -- Chapter 10. The Press Hates Me-Bad reviews -- Chapter 11. I'm Bankrupt-Saving costs and finding profits -- Chapter 12. I Got Fired and I'm the Founder-How? -- Chapter 13. Sold!-Now what? -- Index"]
[null,null,null,"Sommario/riassunto","Start-ups, like sailing vessels, do not travel in straight lines. The wind and the waves of the real world move the ship, and your start-up, in unpredictable ways. This book is designed to give you an analytical set of tools to help you navigate your start-up or corporate innovation through the murky waters of real life. Every business has failures. No business succeeds without some change of plan. Navigating Your Way to Start-up Success will show you how to create a start-up designed to test its assumptions so those that are not worthy fail-often and fast. This book builds on modern start-up management techniques like Agile and Lean to bring an analytical and quantitative framework to the most common start-up failures. Navigating through those failures means finding your way to start-up success. Harlan T Beverly, PhD holds a BS in Electrical and Computer Engineering, an MBA from UT Austin, and a PhD in Business from Oklahoma State University. Harlan "]
[{"$nulls":4},"teaches entrepreneurship at the University of Texas at Austin. He is also Assistant Director of the Jon Brumley Texas Venture Labs at UT Austin, the world's first university business accelerator. Harlan has successfully launched five hardware and 15 software products including the Killer NIC, 2007 Network Product of the Year (CPU Magazine). He has raised over"]
[null,"3.","Record Nr.",null,"UNINA9910557545103321"]
[null,null,"Autore",null,"Willaert Ronnie G"]
[null,null,"Titolo",null,"Yeast Biotechnology 3.0"]
[null,null,"Pubbl/distr/stampa",null,"Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020"]
[null,null,"Descrizione fisica",null,"1 online resource (240 p.)"]
[null,null,"Soggetti",null,"Technology: general issues"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Sommario/riassunto","Yeasts are truly fascinating microorganisms. Due to their diverse and dynamic activities, they have been used for the production of many interesting products, such as beer, wine, bread, biofuels and biopharmaceuticals. Saccharomyces cerevisiae (bakers' yeast) is the yeast species that is surely the most exploited by man. Saccharomyces is a top choice organism for industrial applications, although its use for producing beer dates back to at least the 6th millennium BC. Bakers' yeast has been a cornerstone of modern biotechnology, enabling the development of efficient production processes for antibiotics, biopharmaceuticals, technical enzymes, and ethanol and biofuels. Today, diverse yeast species are explored for industrial applications, such as e.g. Saccharomyces species, Pichia pastoris and other Pichia species, Kluyveromyces marxianus, Hansenula polymorpha, Yarrowia lipolytica, Candida species, Phaffia rhodozyma, wild yeasts for beer brewing, etc. This Special Issue is focused on recent developments of yeast biotechnology with topics including recent techniques for characterizing yeast and their physiology (including omics and nanobiotechnology techniques), methods to adapt industrial strains (including metabolic, synthetic and evolutionary engineering) and the use of yeasts as microbial cell factories to produce biopharmaceuticals, enzymes, alcohols, organic acids, flavours and fine chemicals, and advances in yeast fermentation technology and industrial fermentation processes."]