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[null,"1.","Record Nr.",null,"UNINA9910886966203321"]
[null,null,"Autore",null,"Mansell Charmian"]
[null,null,"Titolo",null,"Female Servants in Early Modern England"]
[null,null,"Pubbl/distr/stampa",null,"Oxford : , : British Academy, , 2024"]
[{"$nulls":4},"©2024"]
[null,null,"ISBN",null,"1-80596-102-0"]
[{"$nulls":4},"0-19-890865-2"]
[{"$nulls":4},"0-19-890866-0"]
[null,null,"Edizione",null,"[1st ed.]"]
[null,null,"Descrizione fisica",null,"1 online resource (438 pages)"]
[null,null,"Collana",null,"British Academy Monographs"]
[null,null,"Disciplina",null,"331.7616404609420903"]
[null,null,"Soggetti",null,"Women household employees - England - History"]
[{"$nulls":4},"Households - England - History"]
[{"$nulls":4},"England Social life and customs"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,"Nota di contenuto",null,"Cover -- Half-title -- A British Academy Monograph -- Title page -- Copyright information -- Table of contents -- List of Figures -- List of Plates -- List of Tables -- Note on the Text -- Abbreviations -- Conventions -- Acknowledgments -- Introduction -- Service in early modern England -- Church courts -- Methodology -- Landscapes, economies, and people -- How to use this book -- Part I -- 1 Church Courts and Their People -- Charting litigation -- Types of litigation -- Record survival -- Coming to court -- Gendered litigation -- Witnessing across the life cycle -- Means to testify -- Female servants in the church courts -- Identification -- Participation -- The servant witness -- The litigating servant -- Shadowy servants -- Conclusion -- 2 Tracing Lives -- Servants and status -- Signs and marks -- Expressing wealth -- Masters and mobility -- Hiring households -- Servant prospects -- Conclusion -- 3 Time for Service -- The age structure of service -- Early years -- Life-cycle servants -- Married women -- Never married -- Widowhood -- Conclusion -- Part II -- 4 On the Move -- Migration patterns -- Beyond the parish -- Patterns of service -- Length of employment -- The labour market -- On hiring fairs -- Finding work -- Family connections -- Conclusion -- 5 Navigating Service -- Patterns of labour -- With or without covenant -- Terms of agreement -- Wage negotiations -- Breaking agreements -- Conclusion -- 6 Working Lives -- Counting and categorising labour -- "]
[{"$nulls":4},"Time for work -- Seasonality of work -- The working week -- Time of day -- Accounting for labour -- Household economies -- Division of labour -- Calculating labour -- Training and skills -- Conclusion -- Part III -- 7 The Home and Beyond -- Categorising space -- Imagining space -- The home -- Beyond the home -- (En)forcing hierarchies -- Policing intimacy -- Discipline and labour."]
[{"$nulls":4},"Conclusion -- 8 Neighbours and Networks -- Familiarity and acquaintance -- Acquaintances -- Familiars -- Friendship -- Friendships and alliances -- Witnessing after service -- Reputation -- Conclusion -- 9 Remembering Service -- Retrieving memories -- Memories of labour -- Local histories -- National horizons -- Conclusion -- Conclusion -- Appendix -- Bibliography -- Subject Index -- Place Index -- Person Index."]
[null,null,null,"Sommario/riassunto","Excavating experiences of over a thousand women in service from church court testimony, Mansell argues that early modern service was unstable, but finely graded, fluid, and contingent. Intervening in histories of labour, gender, freedom, and law, Female Servants in Early Modern England rethinks our understanding of the institution of service."]
[null,"2.","Record Nr.",null,"UNINA9910557257503321"]
[null,null,"Autore",null,"Tsuji Moriya"]
[null,null,"Titolo",null,"Development of Humanized Mouse Models for Infectious Diseases and Cancer"]
[null,null,"Pubbl/distr/stampa",null,"Frontiers Media SA, 2020"]
[null,null,"Descrizione fisica",null,"1 online resource (169 p.)"]
[null,null,"Soggetti",null,"Immunology"]
[{"$nulls":4},"Medicine and Nursing"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Sommario/riassunto","While the traditional animal models contributed immensely to biomedical research there remain many knowledge gaps in translating the results from these to humans. In this context, humanized mice transplanted with functional human cells in a physiological setting offer many advantages in deriving pre-clinical data more akin to that seen in the natural human host. There have been many recent advances in the field that encompass derivation of new transgenic breeds of immunodeficient mice harboring human cytokines and HLA alleles that permit improved human cell engraftment and differentiation. The ability to generate humanized mice with a functional immune system together with human tissue transplantation such as a functional liver has now paved the way for new experimentation not previously feasible and is beginning to shed light on the complex picture of human pathophysiology and immunopathogenesis. Specifically, human specific pathogens such as HIV, hepatitis viruses and malaria parasites are being studied in these systems and important data on pathogen life cycles in human cells in vivo, viral latency and human specific immune responses are being gathered. In the hematology front, new data are emerging on graft versus host disease using these models. Patient derived xenograft models endowed with transplanted human immune cells are permitting evaluations of various immunotherapies and identification of specific drugs for cancer therapy. Pathogenesis and immune responses for deadly pathogens, such as Ebola and newly emerged viruses like Zika are also being studied, adding a new twist "]
[{"$nulls":4},"and generating new knowledge in the context of human target cells in an in vivo setting."]