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[null,null,"Titolo",null,"Oligonucleotide-based drugs and therapeutics : preclinical and clinical considerations for development / / edited by Nicolay Ferrari, Rosanne Seguin"]
[null,null,"Pubbl/distr/stampa",null,"John Wiley & Sons, Inc"]
[null,null,"ISBN",null,"1-119-07030-9"]
[{"$nulls":4},"1-119-07029-5"]
[{"$nulls":4},"1-119-07015-5"]
[null,null,"Disciplina",null,"572.8/5"]
[null,null,"Soggetti",null,"Oligonucleotides - Therapeutic use"]
[{"$nulls":4},"Antisense nucleic acids - Therapeutic use"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,"Nota di contenuto",null,"Mechanisms of oligonucleotide actions -- The medicinal chemistry of antisense oligonucleotides -- Cellular pharmacology of antisense oligonucleotides -- Pharmacokinetics and pharmacodynamics of antisense oligonucleotides -- Tissue distribution, metabolism and clearance -- Hybridization-independent effects : principles and specific considerations for oligonucleotide drugs -- Hybridization-dependent effects : the prediction, evaluation and consequences of unintended target hybridization -- Class-related proinflammatory effects -- Exaggerated pharmacology -- Genotoxicity tests for novel oligonucleotide-based therapeutics -- Reproductive and developmental toxicity testing strategies for oligonucleotide-based therapeutics -- Specific considerations for preclinical development of inhaled oligonucleotides -- Lessons learned in oncology programs -- Inhaled antisense for treatment of respiratory disease -- Antisense oligonucleotides for treatment of neurology diseases -- Nucleic acids as adjuvants -- Splice-switching oligonucleotides -- CMC aspects for the clinical development of spiegelmers."]