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[null,"1.","Record Nr.",null,"UNINA9910812048003321"]
[null,null,"Autore",null,"Yin Guosheng"]
[null,null,"Titolo",null,"Clinical trial design : Bayesian and frequentist adaptive methods / / Guosheng Yin"]
[null,null,"Pubbl/distr/stampa",null,"Hoboken, N.J., : John Wiley & Sons, c2012"]
[null,null,"ISBN",null,"9786613425140"]
[{"$nulls":4},"9781283425148"]
[{"$nulls":4},"1283425149"]
[{"$nulls":4},"9781118183328"]
[{"$nulls":4},"1118183320"]
[{"$nulls":4},"9781118183335"]
[{"$nulls":4},"1118183339"]
[{"$nulls":4},"9781118183304"]
[{"$nulls":4},"1118183304"]
[null,null,"Edizione",null,"[1st ed.]"]
[null,null,"Descrizione fisica",null,"1 online resource (366 p.)"]
[null,null,"Collana",null,"Wiley series in probability and statistics"]
[null,null,"Disciplina",null,"610.72/4"]
[null,null,"Soggetti",null,"Clinical trials - Statistical methods"]
[{"$nulls":4},"Bayesian statistical decision theory"]
[{"$nulls":4},"Mathematical statistics"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and indexes."]
[null,null,"Nota di contenuto",null,"Fundamentals of clinical trials -- Frequentist versus Bayesian statistics -- Phase I trial design -- Phase II trial design -- Phase III trial design -- Adaptive randomization -- Late onset toxicity -- Drug combination trials -- Targeted therapy design."]
[null,null,null,"Sommario/riassunto","A balanced treatment of the theories, methodologies, and design issues involved in clinical trials using statistical methods  There has been enormous interest and development in Bayesian adaptive designs, especially for early phases of clinical trials. However, for phase III trials, frequentist methods still play a dominant role through controlling type I and type II errors in the hypothesis testing framework. From practical perspectives, Clinical Trial Design: Bayesian and Frequentist Adaptive Methods provides comprehensive coverage of both Bayesian and frequentist approaches to a"]
[null,"2.","Record Nr.",null,"UNINA9910548176603321"]
[null,null,"Autore",null,"González Quintero Catalina"]
[null,null,"Titolo",null,"Academic Skepticism in Hume and Kant : A Ciceronian Critique of Metaphysics / / by Catalina González Quintero"]
[null,null,"Pubbl/distr/stampa",null,"Cham : , : Springer International Publishing : , : Imprint : Springer, , 2022"]
[null,null,"ISBN",null,"9783030897505"]
[{"$nulls":4},"9783030897499"]
[null,null,"Edizione",null,"[1st ed. 2022.]"]
[null,null,"Descrizione fisica",null,"1 online resource (281 pages)"]
[null,null,"Collana",null,"Synthese Library, Studies in Epistemology, Logic, Methodology, and Philosophy of Science, , 2542-8292 ; ; 449"]
[null,null,"Disciplina",null,"149.73"]
[null,null,"Soggetti",null,"Philosophy - History"]
[{"$nulls":4},"Science - History"]
[{"$nulls":4},"History of Philosophy"]
[{"$nulls":4},"History of Science"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,"Nota di contenuto",null,"1. Introduction -- 2. The Skepticism of the New Academy: From Epoche to Persuasion -- 3. Academic Skepticism and Metaphysics: On the Gods and the Immortal Soul -- 4. Hume's Academic Skepticism: A Normative Theory of Belief -- 5. Hume and Cicereo on Metaphysics: Philo's Non-dogmatic Deism -- 6. Skepticism vs. Skeptical Method: Sources of Ancient and Modern Skepticism in Kant -- 7. Kant’s Critical Solution to the Antinomies as an Academic Response to the Apraxia Objection -- 8. Conclusion."]
[null,null,null,"Sommario/riassunto","This book offers an unprecedented study of the influence of the skepticism of the New Platonic Academy on David Hume’s and Immanuel Kant’s critiques of metaphysics. By demonstrating how the skeptical teachings of the Academy affected these authors’ Enlightened attacks on traditional metaphysics, this book deepens and broadens the burgeoning scholarship on the role that the Ancients schools of skepticism played in the configuration of Modern skeptical outlooks. It bolsters the newfound recognition that we must reconsider the conventional view that the revival of Pyrrhonism in the sixteenth and seventeenth centuries gave birth to Modern skepticism by incorporating the influence of Academic skepticism in the analysis. Giving a new impetus to this line of research, the author argues that Academic ideas "]
[{"$nulls":4},"and methods informed Hume’s and Kant’s critique of metaphysics in substantial and thus far unacknowledged ways. Specifically, she demonstrates the centrality of Academic skepticismto Hume’s epistemology and critique of religion through a detailed analysis of his theory of belief in the Treatise and the first Enquiry as well as of its application in the Dialogues concerning Natural Religion. Likewise, her analysis reveals how Kant’s anti-metaphysical stance, developed in the Transcendental Dialectic of the Critique of Pure Reason, contains many skeptical insights of Academic inspiration, bequeathed to him by Hume."]