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[null,null,"Autore",null,"Sommermeyer Henning"]
[null,null,"Titolo",null,"Clostridioides Difficile : infections, risk factors, prevention and treatment / / Henning Sommermeyer, Jacek Pia̜tek"]
[null,null,"Pubbl/distr/stampa",null,"Cham, Switzerland : , : Springer, , [2021]"]
[{"$nulls":4},"©2021"]
[null,null,"ISBN",null,"3-030-81100-X"]
[null,null,"Descrizione fisica",null,"1 online resource (96 pages)"]
[null,null,"Disciplina",null,"616.3447"]
[null,null,"Soggetti",null,"Clostridium difficile"]
[{"$nulls":4},"Clostridi"]
[{"$nulls":4},"Llibres electrònics"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,"Nota di contenuto",null,"Intro -- Foreword -- Preface -- Acknowledgments -- Contents -- About the Authors -- Abbreviations -- List of Figures -- List of Tables -- 1: Introduction -- 2: Microbiology -- 2.1  Taxonomy -- 2.2  Genome -- 2.3  Epigenome -- 2.4  Life Cycle of C. difficile During Infection -- 2.4.1  Spore -- 2.4.1.1  Spore Core -- 2.4.1.2  Inner Membrane -- 2.4.1.3  Germ Cell Wall -- 2.4.1.4  Cortex -- 2.4.1.5  Outer Membrane -- 2.4.1.6  Coat and Exosporium -- 2.4.2  Germination -- 2.4.2.1  Germinosome Model -- 2.4.2.2  Lock-and-Key Model -- 2.4.3  Sporulation -- References -- 3: Pathophysiology of C. difficile -- 3.1  Toxins TcdA and TcdB -- 3.2  Genetics of TcdA and TcdB -- 3.3  Pathogenicity Locus -- 3.4  Toxinotypes of C. difficile Isolates -- 3.5  Environmental Signals Regulating Toxin Expression -- 3.6  Mechanism of Action and Functional Domains of TcdA and TcdB -- 3.7  Cell Surface Receptors for TcdA and TcdB -- 3.8  Receptor-Mediated Endocytosis and Membrane Translocation -- 3.9  Modification of Small GTPase Proteins as Host Cell Targets of TcdA and TcdB -- 3.10  Influence of TcdA and TcdB on Cell Physiology -- 3.11  Impact on Cell Morphology -- 3.12  Impact on Small GTPase Signaling Pathways -- 3.13  Role of TcdA and TcdB in Disease -- 3.14  Other Toxins Produced by C. difficile -- 3.15  Toxin Profiles of Clinical Isolates -- References -- 4: Epidemiology -- 4.1  Historical Perspective -- 4.2  Hospital- and Community-Acquired CDI -- 4.3  Hypervirulent C. difficile Strain Ribotype 027 (NAP1/BI) -- 4.4  Other Strains of C. difficile -- 4.5  Dual "]
[{"$nulls":4},"Strain Infections -- 4.6  CDI in Children -- 4.7  Recurrent CDI -- References -- 5: Risk Factors for CDI -- 5.1  Exposure to Healthcare Institutions -- 5.2  Antibiotics -- 5.3  Proton Pump Inhibitors -- 5.4  Advanced Age as Risk Factor for CDI -- 5.5  Cancer Therapy as Risk Factor for CDI."]
[{"$nulls":4},"5.6  Other Risk Factors for CDI -- 5.7  Risk Factors for Community-Acquired CDI -- 5.8  Risk Factors for Recurrent CDI -- 5.9  CDI Risk Factors in Children -- References -- 6: Diagnosis of CDI -- References -- 7: Clinical Picture of CDI -- 7.1  From Asymptomatic Carriers to Life-Threatening Presentations -- 7.2  Pseudomembranous Colitis -- References -- 8: Treatment of CDI -- 8.1  Antibiotics-Based Therapy -- 8.1.1  Antibiotics Used for Treatment of CDI -- 8.1.2  AB-Treatment of an Initial, Non-severe CDI Episode in Adults -- 8.1.3  AB-Treatment of a Fulminant Episode of CDI in Adults -- 8.1.4  AB-Treatment of a First or Multiple Recurrence of CDI in Adults -- 8.1.5  AB-Treatment of Non-severe Initial or First Recurrent CDI in Children -- 8.1.6  AB-Treatment of an Initial Episode of Severe CDI in Children -- 8.1.7  AB-Treatment of Second or Greater Episode of Recurrent CDI in Children -- 8.2  Fecal Microbiota Transplantation as Treatment for CDI -- 8.3  Probiotics and Synbiotics as Treatment for CDI -- 8.4  Surgical Treatment of Complicated CDI -- References -- 9: Prophylaxis of CDI -- 9.1  Probiotics and Synbiotics for Prophylaxis of CDI -- 9.2  Bezlotoxumab for the Prevention of Recurrent CDI -- References -- 10: Summary and Discussion -- 10.1  Spores -- 10.2  Pathophysiology -- 10.3  Epidemiology -- 10.4  Risk Factors -- 10.5  Diagnosis -- 10.6  Clinical Picture -- 10.7  Treatment -- 10.8  Prophylaxis -- 10.9  General Outlook."]