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[null,null,"Titolo",null,"Heat shock proteins in human diseases / / Alexzander A. A. Asea and Punit Kaur (editors)"]
[null,null,"Pubbl/distr/stampa",null,"Cham, Switzerland : , : Springer, , [2021]"]
[{"$nulls":4},"©2021"]
[null,null,"ISBN",null,"3-030-62289-4"]
[null,null,"Descrizione fisica",null,"1 online resource (301 pages) : illustrations"]
[null,null,"Collana",null,"Heat Shock Proteins ; ; v.21"]
[null,null,"Disciplina",null,"572.6"]
[null,null,"Soggetti",null,"Heat shock proteins - Physiological effect"]
[{"$nulls":4},"Proteïnes"]
[{"$nulls":4},"Neuroimmunologia"]
[{"$nulls":4},"Malalties"]
[{"$nulls":4},"Llibres electrònics"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Intro -- Preface -- Contents -- About the Editors -- Inter-Relationship Between the Inflammation and Heat Shock Protein in Cancer Development: A Possible Target for Diagnosis and ... -- 1 Introduction -- 2 Cancer, Inflammation and HSP -- 2.1 Role of Inflammation in Cancer Development -- 2.2 Role of Heat Shock Proteins (HSP) in Cancer Development -- 2.3 Relationship Between HSP and Inflammation in Cancer Development -- 3 Role of the Immune System and HSP in Cancer Diagnosis and Prevention -- 3.1 Ingenious Tumour Immune Surveillance Mechanism to Prevent Cancer -- 3.2 HSP as a Biomarker for Cancer Diagnosis -- 3.3 Targeting the HSP-Inflammation Cooperative System as a Target for Cancer Diagnosis Therapeutics -- 3.4 HSP Based Cancer Immunotherapy -- 3.4.1 Vaccines Based on HSP -- 3.4.2 Immune Responses Stimulation Using HSP as an Antigen -- 3.4.3 The Application of HSP as an Adjuvant for the Immune System Stimulation -- 4 Conclusions -- References -- Chaperonin Hsp60 and Cancer Therapies -- 1 Introduction -- 2 Human Hsp60 and Its Bacterial Orthologues -- 2.1 Hsp60 vs. GroEL -- 2.2 Hsp60 and Autoimmune Diseases -- 3 Hsp60 in Carcinogenesis -- 3.1 Chaperonopathy by Mistake -- 3.2 Hsp60 in Cancer -- 4 Hsp60 in Cancer Management -- 4.1 Exosomes: Definition and Biogenesis -- 4.2 Exosomes in Disease: Cancer -- 4.3 Exosomal Hsp60 in Tumorigenesis -- 5 Hsp60 in Cancer "]
[{"$nulls":4},"Therapy -- 5.1 Hsp and the Immune System -- 5.2 Hsp60-Associated Vaccines in Tumors -- 5.3 Exosomal Hsp60 for Tumor Therapy -- 6 Conclusions -- References -- Combined Thermotherapy and Heat Shock Protein Modulation for Tumor Treatment -- 1 Introduction -- 1.1 Heat Shock Proteins in Cancer Cells -- 1.1.1 Intracellular HSP -- 1.1.2 Extracellular HSP in Cancer -- 1.2 Heat Shock Protein Modulation as a Target for Cancer Therapy -- 1.2.1 Targeting Hsp90 -- 1.2.2 Targeting Hsp70."]
[{"$nulls":4},"1.2.3 Targeting Hsp60 in Cancer -- 1.2.4 Targeting Hsp27 in Cancer -- 1.3 Targeted Cancer Thermotherapy -- 1.3.1 Nanoparticles in Cancer Therapy -- 1.3.2 SPIONs -- 1.3.3 Synthesis Approaches -- 1.3.4 Chemical Synthesis: Co-precipitation -- 1.3.5 SPIONs Enhancement: Surface Functionalization -- 1.3.6 Targeting -- 1.3.7 Magnetic Field-Induced Hyperthermia -- 1.4 Combined HSP Targeting with Hyperthermia -- 2 Conclusions -- References -- Small Molecule Inhibitors Targeting Heat Shock Response Pathways: Lessons from Clinical and Preclinical Studies in Cancer Ther... -- 1 Introduction -- 2 HSR Inhibitors Currently in Human Clinical Studies (Table 1 and Fig. 2) -- 2.1 Quercetin -- 2.2 QC12 (Analog Prodrug of Quercetin) -- 2.3 Triptolide -- 2.4 Minnelide (Analog Prodrug of Triptolide) -- 3 HSR Inhibitors Currently in Preclinical Animal Studies (Table 2 and Fig. 3) -- 3.1 PW3405 -- 3.2 Cantharidin -- 3.3 KNK437 -- 3.4 KRIBB11 -- 3.5 Fisetin -- 3.6 Racoglamide A -- 3.7 CCT251236 -- 4 HSR Inhibitors in Early Preclinical Studies (Cancer Cell Lines, Table 3 and Fig. 4) -- 5 Lessons Learned from Preclinical and Clinical Studies -- 5.1 Improvement of Therapeutic Window by Prodrug Design and Nanoparticle Packaging -- 5.2 Combined Application with Chemotherapy Drugs or Drugs against a Different Cancer Target -- 5.3 Target Validation and Use of RNA Aptamer -- 5.4 HSF1 as a Potential Biomarker for Clinical Trial Design and Prognosis Prediction -- 6 Conclusions -- References -- Multifaceted Roles of Heat Shock Factor 1 (HSF 1) in Cancer -- 1 Introduction -- 2 HSF1 Becomes Constitutively Activated Within Cancer Cells -- 2.1 Activation of HSF1 by the Oncogenic RAS Signaling Pathway -- 2.2 Activation of HSF1 by Other Oncogenic Signaling Pathways -- 2.3 Inactivation of HSF1 by Metabolic Stress Signaling -- 2.4 Other Signaling Pathways Suppress HSF1 Through Phosphorylation."]
[{"$nulls":4},"3 HSF1 Enables Oncogenesis Through Multifaceted Mechanisms -- 3.1 Guarding Proteomic Stability in Cancer -- 3.2 Preventing Cell Senescence and Promoting Survival -- 3.3 Contributing to Genomic Instability and Alleviating Genotoxic Stress -- 4 Enhancing Tumor Cell Invasion and Metastasis -- 4.1 Augmenting Critical Oncogenic Signaling Pathways -- 4.2 Reprogramming Cancer Metabolism -- 4.3 Modulating Tumor Immune Evasion -- 4.4 Promoting Oncogenic Growth Non-cell-autonomously -- 5 HSF1 Is a Potential Therapeutic Target and Prognostic Marker -- 6 Conclusions -- References -- Exploring the Role of Heat Shock Proteins in the Development of Gastric Cancer -- 1 Introduction -- 2 Heat Shock Proteins -- 3 Mode of Action -- 4 HSP27 -- 5 HSP40 -- 6 HSP60 -- 7 HSP70 -- 8 HSP90 -- 9 Differential Expression of Hsp in Gastric Cancer -- 10 HSP70 -- 11 HSP40 -- 12 HSP60 -- 13 Hsp27 -- 14 HSP90 -- 15 Diagnostic and Prognostic Applications of HSP in Gastric Cancer -- 16 HSP70 in H. pylori and EBV Positive Gastric Cancer -- 17 Genetic Polymorphism of HSP70 in Gastric Cancer -- 18 Inhibitors of HSP -- 19 HSP70 Based Vaccines -- 20 Conclusions -- References -- Heat Shock Proteins in Atrial Fibrillation -- 1 Introduction -- 2 HSP and Electrical Remodeling in AF -- 3 HSP and Structural Remodeling in AF -- 4 HSP and Inflammatory Reactions in AF -- 5 HSP and Oxidative Stress in AF -- 6 "]
[{"$nulls":4},"Clinical Application of HSP -- 7 Conclusions -- References -- Threading Microarrays into Novel Applications -- 1 Introduction -- 1.1 HSP90 as a Stress Marker -- 1.2 HSP90-Oriented Screening of Compound Libraries by the Use of Protein Microarrays (PMA) -- 1.3 Novel Applications by Protein Microarrays (PMA) -- 1.3.1 Quantum Dots as a Sensor for Biomarker -- Studying Mutational Effects by PMA -- 2 Conclusions -- References."]
[{"$nulls":4},"Regulation of Kaposi´s Sarcoma-Associated Herpesvirus Biology by Host Molecular Chaperones -- 1 Introduction -- 1.1 KSHV Lifecycle and Biology -- 1.2 KSHV Structure -- 1.3 KSHV Associated Malignancies -- 1.4 KSHV, Protein Folding and Molecular Chaperones -- 1.5 KSHV and Hsp90 -- 1.6 Hsp70 and KSHV -- 1.7 Endoplasmic Reticulum Chaperones and KSHV -- 1.8 KSHV and Nucleophosmin -- 1.9 Putative Candidate KSHV Chaperone Clients Inferred from Proteomics Datasets -- 2 Conclusions -- References -- Role of Heat Shock Factors in Diseases and Immunity -- 1 Introduction -- 1.1 Heat Shock Factors - Functions, Characteristics, Organization and Role in Diseases -- 1.1.1 Heat Shock Response and Importance of HSF -- 1.1.2 Organization and Regulation of HSF -- 1.1.3 PTMs and HSF -- 1.1.4 Importance of Small Molecules in HSF Activation -- 1.1.5 Relationship Between HSF, Diseases and Immunity -- HSF and Cancer -- HSF and Neurodegenerative Diseases -- HSF and Bacterial Infections -- 1.1.6 HSF and Its Turnover Mechanism -- 2 Conclusions -- References -- Heat Shock Proteins and Pain -- 1 Introduction -- 1.1 Inflammation and Pain -- 1.1.1 Pain Signaling -- 1.1.2 Inflammation and Pain -- 1.2 Heat Shock Proteins and Pain -- 1.2.1 Small Heat Shock Proteins(sHsp) -- 1.2.2 Heat Shock Protein 60 (Hsp60) -- 1.2.3 Heat Shock Protein 70 (Hsp70) -- 1.2.4 Heat Shock Protein 90 (Hsp90) -- 1.3 Heat Shock Proteins and Pain Management -- 1.3.1 sHsp -- 1.3.2 Hsp70 -- 1.3.3 Hsp90 -- 2 Conclusions -- References -- HSF1 Regulates Cellular Senescence: Role of the DHRS2-MDM2-p53 Pathway -- 1 Introduction -- 1.1 Cellular Senescence -- 1.2 Acute Depletion of HSF1 Induces Cellular Senescence -- 1.3 Role of HDIS in Tumorigenesis -- 1.3.1 The DHRS2-MDM2-p53 Pathway -- 1.4 Role of HDIS in Age-Related Pathologies -- 2 Conclusions -- References."]
[{"$nulls":4},"Huntingtin Yeast Two-Hybrid Protein K (HYPK): An Intrinsically Unstructured Heat Shock Inducible Protein with Diverse Cellular... -- 1 Introduction -- 1.1 Regulation of Heat Shock Proteins by HSF1 -- 1.2 Functions of Heat Shock Proteins -- 1.3 Characteristics of Intrinsically Unstructured/Disordered Protein (IUP/IDP) -- 1.4 Huntingtin Yeast Two-Hybrid Protein K (HYPK) Is an Intrinsically Unstructured/Disordered Protein (IUP/IDP) -- 1.5 In Vitro and In Vivo Chaperone Activity of HYPK -- 1.6 HYPK Binds with Newly Synthesized Peptides/Proteins -- 1.7 HYPK Interacting Proteins -- 1.8 Chaperones Are in Hub of Protein-Protein Interaction Network -- 1.9 HYPK Is Associated with Aggregate Prone Proteins -- 1.10 Thermal Stress, Hypoxia and Proteasome Inhibitor MG132 Enhance Expression of HYPK in Cultured Cells -- 1.11 HSF1 Binds to the Promoter Sequence of HYPK and Regulates the Expression -- 1.12 HYPK Negatively Regulates Heat Shock Response -- 1.13 HSF1 Also Regulate HYPK Conjoined SERF2 Gene -- 1.14 Functions of HYPK -- 1.15 Does HYPK Modify Expression of Other Genes? -- 1.16 Does HYPK Play Any Role Human Disease? -- 2 Conclusions -- References -- Roles of HSP on Antigen Presentation -- 1 Introduction -- 1.1 Mechanisms of Antigen Presentation by Dendritic Cells -- 1.2 Roles of HSP in Antigen Presentation by MHC-I -- 1.3 Roles of HSP in Antigen Presentation by MHC-II -- 2 Conclusions -- References -- Heat Shock Proteins Mediate Anastasis and Plasticity of Thermotolerant Cells -- 1 Introduction -- 2 Apoptosis -- 2.1 The Role "]
[{"$nulls":4},"of Mitochondria in Apoptosis -- 2.2 The Role of Death Receptors in Apoptosis -- 3 Thermotolernce and Anastasis -- 4 Role of HSP in Anastasis -- 5 Conclusions and Perspectives -- References -- Index."]