{"text_format":"2","workbook":"xls","n_sheets":1,"sheets":["report2"],"not_rendered":{"charts":0,"images":0,"macros":0,"external_links":1,"defined_names":2,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"run_cost":"one","rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"report2","index":0,"n_rows":58,"n_cols":5,"rows_kept":58,"cut":false,"hidden":false,"merged":[[0,2,0,3],[0,4,0,5],[1,2,1,3],[1,4,1,5],[2,2,2,3],[2,4,2,5],[3,2,3,3],[4,2,4,3],[11,2,11,3],[12,2,12,3],[13,2,13,3],[14,2,14,3],[15,2,15,3],[18,2,18,3],[19,2,19,3],[23,2,23,3],[31,2,31,3],[31,4,31,5],[32,2,32,3],[32,4,32,5],[33,2,33,3],[34,2,34,3],[36,2,36,3],[37,2,37,3],[38,2,38,3],[39,2,39,3],[40,2,40,3],[51,2,51,3],[52,2,52,3],[55,2,55,3]],"flags":["formulas_cached_only"]}
[null,"1.","Record Nr.",null,"UNINA9910816988403321"]
[null,null,"Autore",null,"Tung Hsien-Hsin <1955->"]
[null,null,"Titolo",null,"Crystallization of organic compounds : an industrial perspective / / Hsien-Hsin Tung ... [et al.]"]
[null,null,"Pubbl/distr/stampa",null,"Hoboken, N.J., : Wiley, c2009"]
[null,null,"ISBN",null,"9786612368295"]
[{"$nulls":4},"9781282368293"]
[{"$nulls":4},"128236829X"]
[{"$nulls":4},"9780470447796"]
[{"$nulls":4},"0470447796"]
[{"$nulls":4},"9780470447789"]
[{"$nulls":4},"0470447788"]
[null,null,"Edizione",null,"[1st ed.]"]
[null,null,"Descrizione fisica",null,"1 online resource (304 p.)"]
[null,null,"Classificazione",null,"VE 9500"]
[null,null,"Disciplina",null,"615/.19"]
[null,null,"Soggetti",null,"Crystallization - Industrial applications"]
[{"$nulls":4},"Pharmaceutical chemistry"]
[{"$nulls":4},"Pharmaceutical industry"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Crystallization of Organic Compounds; Contents; Preface; 1. Introduction to Crystallization Issues; 1.1 Crystal Properties and Polymorphism (Chapters 2 and 3); 1.2 Nucleation and Growth Kinetics (Chapter 4); 1.3 Critical Issues (Chapter 5); 1.4 Mixing and Crystallization (Chapter 6); 1.5 Crystallization Process Options (Chapters 7-10); 1.6 Special Applications (Chapter 11); 1.7 Regulatory Issues; 2. Properties; 2.1 Solubility; 2.2 Supersaturation, Metastable Zone, and Induction Time; 2.3 Oil, Amorphous, and Crystalline States; 2.4 Polymorphism; 2.5 Solvate"]
[{"$nulls":4},"2.6 Solid Compound, Solid Solution, and Solid Mixture2.7 Inclusion and Occlusion; 2.8 Adsorption, Hygroscopicity, and Deliquescence; 2.9 Crystal Morphology; 2.10 Particle Size Distribution and Surface Area; 3. Polymorphism; 3.1 Phase Rule; 3.2 Phase Transition; 3.3 Examples; Example 3-1 Indomethacin; Example 3-2 Sulindac; Example 3-3 Losartan; Example 3-4 Finasteride; Example 3-5 Ibuprofen Lysinate; Example 3-6 HCl Salt of a Drug Candidate; Example 3-7 Second HCl Salt of a Drug Candidate; Example 3-8 Prednisolone t-Butylacetate; "]
[{"$nulls":4},"Example 3-9 Phthalylsulfathiazole; 3.4 Future Direction"]
[{"$nulls":4},"4. Kinetics4.1 Supersaturation and Rate Processes; 4.2 Nucleation; 4.3 Crystal Growth; 4.4 Nucleate/Seed Aging and Ostwald Ripening; 4.5 Delivered Product: Size Distribution and Morphology; 5. Critical Issues in Crystallization Practice; 5.1 Introduction; 5.2 Nucleation; 5.3 Growth; 5.4 Oiling Out, Agglomeration/Aggregation; 5.5 Seeding; 5.6 Rate of Generation of Supersaturation; 5.7 Summary of Critical Issues; 6. Mixing and Crystallization; 6.1 Introduction; 6.2 Mixing Considerations; 6.3 Mixing Effects on Nucleation; 6.4 Mixing Effects on Crystal Growth; 6.5 Mixing Scale-up"]
[{"$nulls":4},"6.6 Crystallization EquipmentExample 6-1; 7. Cooling Crystallization; 7.1 Batch Operation; 7.2 Continuous Operations; 7.3 Process Design-Examples; Example 7-1 Intermediate in a Multistep Synthesis; Example 7-2 Pure Crystallization of an API; Example 7-3 Crystallization Using the Heel from the Previous Batch as Seed; Example 7-4 Resolution of Ibuprofen Via Stereospecific Crystallization; Example 7-5 Crystallization of Pure Bulk with Polymorphism; Example 7-6 Continuous Separation of Stereoisomers; 8. Evaporative Crystallization; 8.1 Introduction; 8.2 Solubility Diagrams"]
[{"$nulls":4},"8.3 Factors Affecting Nucleation and Growth8.4 Scale-up; 8.5 Equipment; Example 8-1 Crystallization of a Pharmaceutical Intermediate Salt; Example 8-2 Crystallization of the Sodium Salt of a Drug Candidate; 9. Antisolvent Crystallization; 9.1 Semibatch Operation; Example 9-1 Crystallization of an Intermediate; Example 9-2 Rejection of Isomeric Impurities of Final Bulk Active Product; Example 9-3 Crystallization of a Pharmaceutical Product with Poor Nucleation and Growth Characteristics; Example 9-4 Impact of Solvent and Supersaturation on Particle Size and Crystal Form"]
[{"$nulls":4},"9.2 In-Line Mixing Crystallization"]
[null,null,null,"Sommario/riassunto","Filled with industrial examples emphasizing the practical applications of crystallization methodologies Based on the authors' hands-on experiences as process engineers at Merck, Crystallization of Organic Compounds guides readers through the practical aspects of crystallization. It uses plenty of case studies and examples of crystallization processes, ranging from development through manufacturing scale-up. The book not only emphasizes strategies that have been proven successful, it also helps readers avoid common pitfalls that can render standard procedures unsuccessful. The goal o"]
[null,"2.","Record Nr.",null,"UNINA9910483834503321"]
[null,null,"Titolo",null,"Computer Algebra in Scientific Computing : 15th International Workshop, CASC 2013, Berlin, Germany, September 9-13, 2013, Proceedings / / edited by Vladimir P. Gerdt, Wolfram Koepf, Ernst W. Mayr, Evgenii V. Vorozhtsov"]
[null,null,"Pubbl/distr/stampa",null,"Cham : , : Springer International Publishing : , : Imprint : Springer, , 2013"]
[null,null,"ISBN",null,"9783319022970"]
[{"$nulls":4},"3319022970"]
[null,null,"Edizione",null,"[1st ed. 2013.]"]
[null,null,"Descrizione fisica",null,"1 online resource (XVI, 443 p. 58 illus.)"]
[null,null,"Collana",null,"Theoretical Computer Science and General Issues, , 2512-2029 ; ; 8136"]
[null,null,"Disciplina",null,"005.1"]
[null,null,"Soggetti",null,"Algorithms"]
[{"$nulls":4},"Computer science—Mathematics"]
[{"$nulls":4},"Discrete mathematics"]
[{"$nulls":4},"Computer graphics"]
[{"$nulls":4},"Numerical analysis"]
[{"$nulls":4},"Computer arithmetic and logic units"]
[{"$nulls":4},"Discrete Mathematics in Computer Science"]
[{"$nulls":4},"Symbolic and Algebraic Manipulation"]
[{"$nulls":4},"Computer Graphics"]
[{"$nulls":4},"Numerical Analysis"]
[{"$nulls":4},"Arithmetic and Logic Structures"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Bibliographic Level Mode of Issuance: Monograph"]
[null,null,"Nota di contenuto",null,"Polynomial algebra -- the solution of tropical linear systems and tropical polynomial systems -- the theory of matrices -- the use of computer algebra for the investigation of various mathematical and applied topics related to ordinary differential equations -- applications of symbolic computations for solving partial differential equations in mathematical physics -- problems arising at the application of computer algebra methods for finding infinitesimal symmetries -- applications of symbolic and symbolic-numeric algorithms in mechanics and physics -- automatic differentiation -- the application of the CAS Mathematica for the simulation of quantum error correction in quantum computing -- the application of the CAS GAP for the "]
[{"$nulls":4},"enumeration of Schur rings over the group A5 -- constructive computation of zero separation bounds for arithmetic expressions -- the parallel implementation of fast Fourier transforms with the aid of the Spiral library generation system -- the use of object-oriented languages such as Java or Scala for implementation of categories as type classes -- a survey of industrial applications of approximate computer algebra."]
[null,null,null,"Sommario/riassunto","This book constitutes the proceedings of the 14th International Workshop on Computer Algebra in Scientific Computing, CASC 2013, held in Berlin, Germany, in September 2013. The 33 full papers presented were carefully reviewed and selected for inclusion in this book. The papers address issues such as polynomial algebra; the solution of tropical linear systems and tropical polynomial systems; the theory of matrices; the use of computer algebra for the investigation of various mathematical and applied topics related to ordinary differential equations (ODEs); applications of symbolic computations for solving partial differential equations (PDEs) in mathematical physics; problems arising at the application of computer algebra methods for finding infinitesimal symmetries; applications of symbolic and symbolic-numeric algorithms in mechanics and physics; automatic differentiation; the application of the CAS Mathematica for the simulation of quantum error correction in quantum computing; the application of the CAS GAP for the enumeration of Schur rings over the group A5; constructive computation of zero separation bounds for arithmetic expressions; the parallel implementation of fast Fourier transforms with the aid of the Spiral library generation system; the use of object-oriented languages such as Java or Scala for implementation of categories as type classes; a survey of industrial applications of approximate computer algebra."]