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[null,"1.","Record Nr.",null,"UNINA9910454903903321"]
[null,null,"Autore",null,"Fink Dale Borman"]
[null,null,"Titolo",null,"Making a place for kids with disabilities [[electronic resource] /] / Dale Borman Fink"]
[null,null,"Pubbl/distr/stampa",null,"Westport, Conn., : Praeger, 2000"]
[null,null,"ISBN",null,"0-313-00043-3"]
[{"$nulls":4},"0-585-39765-1"]
[null,null,"Descrizione fisica",null,"1 online resource (223 p.)"]
[null,null,"Disciplina",null,"790.1/96"]
[null,null,"Soggetti",null,"Children with disabilities - Recreation - United States"]
[{"$nulls":4},"Youth with disabilities - Recreation - United States"]
[{"$nulls":4},"Sports for people with disabilities - United States"]
[{"$nulls":4},"Electronic books."]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Bibliographic Level Mode of Issuance: Monograph"]
[null,null,null,"Nota di bibliografia","Includes bibliographical references (p. [195]-199) and index."]
[null,"2.","Record Nr.",null,"UNINA9910480192903321"]
[null,null,"Autore",null,"Stark Evan"]
[null,null,"Titolo",null,"Women at risk [[electronic resource] ] : domestic violence and women's health / / Evan Stark, Anne Flitcraft"]
[null,null,"Pubbl/distr/stampa",null,"Thousand Oaks, Calif., : SAGE, c1996"]
[null,null,"ISBN",null,"1-4522-4715-3"]
[{"$nulls":4},"1-322-28346-X"]
[{"$nulls":4},"1-4833-4537-8"]
[null,null,"Descrizione fisica",null,"1 online resource (289 p.)"]
[null,null,"Disciplina",null,"362.82920973"]
[null,null,"Soggetti",null,"Wife abuse - United States"]
[{"$nulls":4},"Family violence - United States"]
[{"$nulls":4},"Abused wives - Medical care - United States"]
[{"$nulls":4},"Abused women - Medical care - United States"]
[{"$nulls":4},"Patriarchy - United States"]
[{"$nulls":4},"Electronic books."]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references (pages 221-237) and indexes."]
[null,null,"Nota di contenuto",null,"\"\"Cover            \"\"; \"\"Contents               \"\"; \"\"Acknowledgments                      \"\"; \"\"Introduction                   \"\"; \"\"Part I - Theoretical Perspectives                                        \"\"; \"\"Chapter 1 - Medicine and Patriarchal Violence                                                    \"\"; \"\"Chapter 2 - Imagining Woman Battering: Social Knowledge, Social Therapy, and Patriarchal Benevolence                                                                                                           \"\"; \"\"Part II - Health Consequences                                    \"\""]
[{"$nulls":4},"\"\"Chapter 3 - Women and Children at Risk: A Feminist Perspective on Child Abuse                                                                                    \"\"\"\"Chapter 4 - Killing the Beast Within: Woman Battering and Female Suicidality\"\"; \"\"Chapter 5 - Preventing Gendered Homicide                                               \"\"; \"\"Part III - Clinical Interventions                                        \"\""]
[{"$nulls":4},"\"\"Chapter 6 - Personal Power and Institutional Victimization: Treating the Dual Trauma of Woman Battering                                                                                                              \"\"\"\"Chapter 7 - Clinical Violence Intervention: Lessons from Battered Women\"\"; \"\"Chapter 8 - Discharge Planning With Battered Women                                                         \"\"; \"\"Chapter 9 - Physicians and Domestic Violence: Challenges for Prevention                                                                              \"\"; \"\"References                 \"\""]
[{"$nulls":4},"\"\"Name Index                 \"\"\"\"Subject Index                    \"\"; \"\"About the "]
[{"$nulls":4},"Authors                        \"\""]
[null,null,null,"Sommario/riassunto","Battering by men is the most significant cause of injury to women in our society. It is also a major cause of child abuse, murder, substance abuse and female suicide attempts. This volume, the result of 15 years of research conducted by the authors - a social worker and physician respectively - explores the theoretical perspectives of this dramatic expression of male domination, together with health consequences for women and clinical interventions.    The authors found that the traditional resources women turn to for help reinforce male domination: the medical, psychiatric and behavioural pro"]
[null,"3.","Record Nr.",null,"UNINA9910829879503321"]
[null,null,"Titolo",null,"Protein-ligand interactions from molecular recognition to drug design [[electronic resource] /] / edited by H.-J. Böhm and G. Schneider"]
[null,null,"Pubbl/distr/stampa",null,"Weinheim, : Cambridge, : Wiley-VCH, 2003"]
[null,null,"ISBN",null,"1-280-52057-4"]
[{"$nulls":4},"9786610520572"]
[{"$nulls":4},"3-527-60551-7"]
[{"$nulls":4},"3-527-60181-3"]
[null,null,"Edizione",null,"[1st ed.]"]
[null,null,"Descrizione fisica",null,"1 online resource (264 p.)"]
[null,null,"Collana",null,"Methods and Principles in Medicinal Chemistry ; ; v.27"]
[null,null,"Disciplina",null,"572.33"]
[{"$nulls":4},"615.19"]
[{"$nulls":4},"615/.19"]
[null,null,"Soggetti",null,"Ligand binding (Biochemistry)"]
[{"$nulls":4},"Biochemistry"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,"Nota di contenuto",null,"Protein-Ligand Interactions From Molecular Recognition to Drug Design; Contents; Preface; A Personal Foreword; List of Contributors; List of Abbreviations; Prologue; 1 Prediction of Non-bonded Interactions in Drug Design; 1.1 Introduction; 1.2 Major Contributions to Protein-Ligand Interactions; 1.3 Description of Scoring Functions for Receptor-Ligand Interactions; 1.3.1 Force Field-based Methods; 1.3.2 Empirical Scoring Functions; 1.3.3 Knowledge-based Methods; 1.4 Some Limitations of Current Scoring Functions; 1.4.1 Influence of the Training Data; 1.4.2 Molecular Size"]
[{"$nulls":4},"1.4.3 Water Structure and Protonation State1.5 Application of Scoring Functions in Virtual Screening and De Novo Design; 1.5.1 Successful Identification of Novel Leads Through Virtual Screening; 1.5.2 De novo Ligand Design with LUDI; 1.6 Outlook; 1.7 Acknowledgments; 1.8 References; 2 Introduction to Molecular Recognition Models; 2.1 Introduction and Scope; 2.2 Additivity of Pairwise Interactions - The Chelate Effect; 2.3 Geometric Fitting: The Hole-size Concept; 2.4 Di- and Polytopic Interactions: Change of Binding Mechanism with Different Fit; 2.5 Deviations from the Lock-and-Key Principle"]
[{"$nulls":4},"2.5.1 Strain in Host-Guest Complexes2.5.2 Solvent Effects; 2.5.3 Enthalpy/Entropy Variations; 2.5.4 Loose Fit in Hydrophobically Driven "]
[{"$nulls":4},"Complex Formation; 2.6 Conformational Pre-organization: Flexible vs. Rigid Hosts; 2.7 Selectivity and Stability in Supramolecular Complexes; 2.8 Induced Fit, Cooperativity, and Allosteric Effects; 2.9 Quantification of Non-covalent Forces; 2.9.1 Ion Pairs and Electrostatic Donor-Acceptor Interactions; 2.9.2 Hydrogen Bonds; 2.9.3 Weak Hydrogen Bonds: The Use of Intramolecular \"\"Balances\"; 2.9.4 Polarization Effects; 2.9.5 Dispersive Interactions"]
[{"$nulls":4},"2.10 Conclusions2.11 References; 3 Experimental Approaches to Determine the Thermodynamics of Protein-Ligand Interactions; 3.1 Introduction; 3.2 Basic Thermodynamics of Protein-Ligand Interactions; 3.3 Measurement of Thermodynamic Parameters; 3.3.1 Calorimetric Determination of Thermodynamic Parameters; 3.3.2 van't Hoff Determination of Thermodynamic Parameters; 3.3.2.1 Relationship to Equilibrium Constant; 3.3.2.2 Obtaining the Equilibrium Constant; 3.4 Applications; 3.4.1 Calorimetric Determination of Thermodynamic Parameters; 3.4.2 van't Hoff Determination of Thermodynamic Parameters"]
[{"$nulls":4},"3.5 Caveats3.6 Summary; 3.7 References; 4 The Biophore Concept; 4.1 Introduction; 4.2 Methodology for Pharmacophore Detection and Searching; 4.2.1 Definition of Pharmacophoric Groups; 4.2.2 Ligand-based Methods for Pharmacophore Perception; 4.2.3 Protein Structure-based Pharmacophore Perception; 4.2.4 Methods for Pharmacophore Searching; 4.3 Pharmacophore Fingerprints; 4.4 Applications of the Biophore Concept; 4.4.1 Lead Generation; 4.4.2 Multi-pharmacophore Descriptors in Diversity Analysis and Library Design; 4.4.3 Structure-based Design; 4.5 The Biophore Concept in ADME Prediction"]
[{"$nulls":4},"4.6 Summary"]
[null,null,null,"Sommario/riassunto","The lock-and-key principle formulated by Emil Fischer as early as the end of the 19th century has still not lost any of its significance for the life sciences. The basic aspects of ligand-protein interaction may be summarized under the term 'molecular recognition' and concern the specificity as well as stability of ligand binding. Molecular recognition is thus a central topic in the development of active substances, since stability and specificity determine whether a substance can be used as a drug. Nowadays, computer-aided prediction and intelligent molecular design make a large contributio"]