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[null,"1.","Record Nr.",null,"UNINA9910460528603321"]
[null,null,"Titolo",null,"General and molecular pharmacology : principles of drug action / / edited by Francesco Clementi [and six others]"]
[null,null,"Pubbl/distr/stampa",null,"Hoboken, New Jersey : , : Wiley, , 2015"]
[{"$nulls":4},"©2015"]
[null,null,"ISBN",null,"1-118-76868-X"]
[{"$nulls":4},"1-118-76859-0"]
[null,null,"Descrizione fisica",null,"1 online resource (2938 p.)"]
[null,null,"Disciplina",null,"615.1/9"]
[null,null,"Soggetti",null,"Pharmaceutical chemistry"]
[{"$nulls":4},"Molecular biology"]
[{"$nulls":4},"Electronic books."]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references at the end of each chapters and index."]
[null,null,"Nota di contenuto",null,"COVER; TABLE OF CONTENTS; TITLE PAGE; LIST OF CONTRIBUTORS; PREFACE; SECTION 1: INTRODUCTION TO PHARMACOLOGY; 1 ESSENTIAL LEXICON OF PHARMACOLOGY; THE SOCIAL IMPACT OF PHARMACOLOGY; ESSENTIAL LEXICON; TAKE-HOME MESSAGE; 2 A SHORT HISTORY OF PHARMACOLOGY; BIRTH AND HISTORICAL DEVELOPMENTS OF PHARMACOLOGY; MODERN PHARMACOLOGY; THE BIOTECHNOLOGY ERA AND THE PHARMACOLOGY IN THE THIRD MILLENNIUM; TAKE-HOME MESSAGE; FURTHER READING; SECTION 2: GETTING THE DRUG TO ITS SITE OF ACTION; 3 CELLULAR BASIS OF PHARMACOKINETICS; A QUICK JOURNEY WITH THE DRUG IN THE BODY; CROSSING CELL MEMBRANES"]
[{"$nulls":4},"DRUG DIFFUSION TO ORGANS AND TISSUES TAKE-HOME MESSAGE; FURTHER READING; 4 DRUG ABSORPTION AND ADMINISTRATION ROUTES; GENERAL RULES ABOUT DRUG ABSORPTION RATE; ENTERAL ROUTES OF ADMINISTRATION; SYSTEMIC PARENTERAL ROUTES OF ADMINISTRATION; OTHER ROUTES OF DRUG ADMINISTRATION; ABSORPTION KINETICS; TAKE-HOME MESSAGE; FURTHER READING; 5 DRUG DISTRIBUTION AND ELIMINATION; DISTRIBUTION; ELIMINATION; RENAL EXCRETION OF DRUGS; HEPATIC EXCRETION AND ENTEROHEPATIC CYCLE; TAKE-HOME MESSAGE; FURTHER READING; 6 DRUG METABOLISM; METABOLIC MODIFICATION OF DRUG ACTIVITY; "]
[{"$nulls":4},"TWO PHASES OF DRUG METABOLISM"]
[{"$nulls":4},"EXTRAHEPATIC BIOTRANSFORMATIONS PHARMACOMETABOLIC INDUCTION AND INHIBITION; TAKE-HOME MESSAGE; FURTHER READING; 7 CONTROL OF DRUG PLASMA CONCENTRATION; TIME COURSE OF DRUG PLASMA CONCENTRATION FOLLOWING A SINGLE ADMINISTRATION; DRUGS DISTRIBUTE TO ORGANS AND TISSUES AND THEN ARE ELIMINATED; DRUG PLASMA CONCENTRATION TIME COURSE DURING REPETITIVE ADMINISTRATIONS; MULTICOMPARTMENTAL KINETICS; CORRECTIONS OF THE THERAPEUTIC REGIMEN; TAKE-HOME MESSAGE; FURTHER READING; SECTION 3: RECEPTORS AND SIGNAL TRANSDUCTION; 8 DRUG-RECEPTOR INTERACTIONS: QUANTITATIVE AND QUALITATIVE ASPECTS"]
[{"$nulls":4},"GENERAL PROPERTIES OF DRUG RECEPTORS CHARACTERISTICS OF DRUG-RECEPTOR INTERACTION; QUANTITATIVE ASPECTS OF DRUG EFFECTS: DOSE-RESPONSE CURVES; FROM DRUG-RECEPTOR INTERACTION TO DRUG RESPONSE; TAKE-HOME MESSAGE; FURTHER READING; 9 RECEPTORS AND MODULATION OF THEIR RESPONSE; CLASSES OF RECEPTORS AND STRATEGIES OF SIGNAL TRANSDUCTION; CONTROL OF RECEPTOR LOCALIZATION IN THE CELL MEMBRANE; INTRACELLULAR TRAFFIC OF CELL RECEPTORS; MODULATION OF RECEPTOR RESPONSES; RECEPTOR MODULATION BY DRUGS; TAKE-HOME MESSAGE; FURTHER READING; 10 ADAPTATION TO DRUG RESPONSE AND DRUG DEPENDENCE"]
[{"$nulls":4},"MOLECULAR, CELLULAR, AND SYSTEMIC ADAPTATION DRUG ADDICTION AS A PARADIGM OF ALLOSTATIC ADAPTATION; THERAPY FOR DRUG DEPENDENCE; TAKE-HOME MESSAGE; FURTHER READING; 11 PHARMACOLOGICAL MODULATION OF POSTTRANSLATIONAL MODIFICATIONS; PROTEIN PHOSPHORYLATION; SUMOylation; UBIQUITINATION; GLYCOSYLATION; ACETYLATION; HYDROXYLATION; CARBOXYLATION; METHYLATION; S-NITROSYLATION; DISULFIDE BONDS; LIPID MODIFICATIONS; PHARMACOLOGICAL MODULATION OF POST TRANSLATIONAL MODIFICATIONS; TAKE-HOME MESSAGE; FURTHER READING; 12 CALCIUM HOMEOSTASIS WITHIN THE CELLS; THE CYTOSOL: A CROSSROAD OF Ca2+ FLUXES"]
[{"$nulls":4},"THE PLASMA MEMBRANE: CHANNELS, PUMPS, AND TRANSPORTERS"]
[null,null,null,"Sommario/riassunto","With a focus on functional relationships between drugs and their targets, this book covers basic and general pharmacology, from a cellular and molecular perspective, with particular attention to the mechanisms of drug action - the fundamental basis for proper clinical use- without neglecting clinical application, toxicology and pharmacokinetics. Covers cell and molecular pharmacology, bringing together current research on regulation of drug targets, at a level appropriate for advanced undergrad and graduate students Discusses the relevance of pharmacokinetics and drug development"]