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[null,"1.","Record Nr.",null,"UNINA9910460106203321"]
[null,null,"Autore",null,"Fleming Daniel E"]
[null,null,"Titolo",null,"The buried foundation of the Gilgamesh epic [[electronic resource] ] : the Akkadian Huwawa narrative / / by Daniel E. Fleming and Sara J. Milstein"]
[null,null,"Pubbl/distr/stampa",null,"Leiden ; ; Boston, : Brill, 2010"]
[null,null,"ISBN",null,"1-282-95067-3"]
[{"$nulls":4},"9786612950674"]
[{"$nulls":4},"90-474-4083-8"]
[null,null,"Descrizione fisica",null,"1 online resource (248 p.)"]
[null,null,"Collana",null,"Cuneiform monographs, , 0929-0052 ; ; v. 39"]
[null,null,"Disciplina",null,"892/.1"]
[null,null,"Soggetti",null,"Epic poetry, Assyro-Babylonian - History and criticism"]
[{"$nulls":4},"Assyriology - History"]
[{"$nulls":4},"Electronic books."]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and indexes."]
[null,null,"Nota di contenuto",null,"Preliminary Material / D. E. Fleming and S. J. Milstein -- Chapter One. Introduction / D. E. Fleming and S. J. Milstein -- Chapter Two. Enkidu’s First Steppe: Competing Portraits Of Enkidu In Yale And Penn / D. E. Fleming and S. J. Milstein -- Chapter Three. Defining The Bounds Of The Akkadian Huwawa Narrative / D. E. Fleming and S. J. Milstein -- Chapter Four. From Sumerian To Akkadian: Major Innovations In The Akkadian Huwawa Tale / D. E. Fleming and S. J. Milstein -- Chapter Five. Behind Penn: Old Babylonian Introductions To The Huwawa Narrative And To The Epic / D. E. Fleming and S. J. Milstein -- Chapter Six. Conclusion / D. E. Fleming and S. J. Milstein -- Bibliography / D. E. Fleming and S. J. Milstein -- Translations: The Early Second-Millennium Evidence / D. E. Fleming and S. J. Milstein -- Subjects / D. E. Fleming and S. J. Milstein -- Akkadian And Sumerian Words / D. E. Fleming and S. J. Milstein -- Author Index / D. E. Fleming and S. J. Milstein -- Citations From The Translated Gilgamesh Texts / D. E. Fleming and S. J. Milstein -- Plates / D. E. Fleming and S. J. Milstein."]
[null,null,null,"Sommario/riassunto","The Akkadian Gilgamesh Epic, perhaps the most famous of Mesopotamian literature, has been considered the artistry of one author inspired by Sumerian tales. Specialists have assumed that all the earliest evidence (ca. 1800-1700 BCE) reflects this creative unity. Deep contrasts in characterization and narrative logic, however, distinguish "]
[{"$nulls":4},"the central adventure to defeat the monster Huwawa from what precedes and follows it. The Huwawa narrative stands on its own, so that the epic must have been composed from this prior Akkadian composition. Recognition of the tale embedded in the epic allows each block of material to be understood on its own terms. Such literary-historical investigation from contemporary texts is new to Assyriology and may produce important results when applied to other Mesopotamian writing. \\'The book is well written and tightly argued...This makes it a first point of reference for anyone interested in the OB evidence for the Gilgamesh Epic.\\' Scott C. Jones, Covenant College"]
[null,"2.","Record Nr.",null,"UNINA9910146240603321"]
[null,null,"Titolo",null,"Protein-ligand interactions from molecular recognition to drug design [[electronic resource] /] / edited by H.-J. Böhm and G. Schneider"]
[null,null,"Pubbl/distr/stampa",null,"Weinheim, : Cambridge, : Wiley-VCH, 2003"]
[null,null,"ISBN",null,"1-280-52057-4"]
[{"$nulls":4},"9786610520572"]
[{"$nulls":4},"3-527-60551-7"]
[{"$nulls":4},"3-527-60181-3"]
[null,null,"Edizione",null,"[1st ed.]"]
[null,null,"Descrizione fisica",null,"1 online resource (264 p.)"]
[null,null,"Collana",null,"Methods and Principles in Medicinal Chemistry ; ; v.27"]
[null,null,"Disciplina",null,"572.33"]
[{"$nulls":4},"615.19"]
[{"$nulls":4},"615/.19"]
[null,null,"Soggetti",null,"Ligand binding (Biochemistry)"]
[{"$nulls":4},"Biochemistry"]
[{"$nulls":4},"Electronic books."]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,"Nota di contenuto",null,"Protein-Ligand Interactions From Molecular Recognition to Drug Design; Contents; Preface; A Personal Foreword; List of Contributors; List of Abbreviations; Prologue; 1 Prediction of Non-bonded Interactions in Drug Design; 1.1 Introduction; 1.2 Major Contributions to Protein-Ligand Interactions; 1.3 Description of Scoring Functions for Receptor-Ligand Interactions; 1.3.1 Force Field-based Methods; 1.3.2 Empirical Scoring Functions; 1.3.3 Knowledge-based Methods; 1.4 Some Limitations of Current Scoring Functions; 1.4.1 Influence of the Training Data; 1.4.2 Molecular Size"]
[{"$nulls":4},"1.4.3 Water Structure and Protonation State1.5 Application of Scoring Functions in Virtual Screening and De Novo Design; 1.5.1 Successful Identification of Novel Leads Through Virtual Screening; 1.5.2 De novo Ligand Design with LUDI; 1.6 Outlook; 1.7 Acknowledgments; 1.8 References; 2 Introduction to Molecular Recognition Models; 2.1 Introduction and Scope; 2.2 Additivity of Pairwise Interactions - The Chelate Effect; 2.3 Geometric Fitting: The Hole-size Concept; 2.4 Di- and Polytopic Interactions: Change of Binding Mechanism with Different Fit; 2.5 Deviations from the Lock-and-Key Principle"]
[{"$nulls":4},"2.5.1 Strain in Host-Guest Complexes2.5.2 Solvent Effects; 2.5.3 "]
[{"$nulls":4},"Enthalpy/Entropy Variations; 2.5.4 Loose Fit in Hydrophobically Driven Complex Formation; 2.6 Conformational Pre-organization: Flexible vs. Rigid Hosts; 2.7 Selectivity and Stability in Supramolecular Complexes; 2.8 Induced Fit, Cooperativity, and Allosteric Effects; 2.9 Quantification of Non-covalent Forces; 2.9.1 Ion Pairs and Electrostatic Donor-Acceptor Interactions; 2.9.2 Hydrogen Bonds; 2.9.3 Weak Hydrogen Bonds: The Use of Intramolecular \"\"Balances\"; 2.9.4 Polarization Effects; 2.9.5 Dispersive Interactions"]
[{"$nulls":4},"2.10 Conclusions2.11 References; 3 Experimental Approaches to Determine the Thermodynamics of Protein-Ligand Interactions; 3.1 Introduction; 3.2 Basic Thermodynamics of Protein-Ligand Interactions; 3.3 Measurement of Thermodynamic Parameters; 3.3.1 Calorimetric Determination of Thermodynamic Parameters; 3.3.2 van't Hoff Determination of Thermodynamic Parameters; 3.3.2.1 Relationship to Equilibrium Constant; 3.3.2.2 Obtaining the Equilibrium Constant; 3.4 Applications; 3.4.1 Calorimetric Determination of Thermodynamic Parameters; 3.4.2 van't Hoff Determination of Thermodynamic Parameters"]
[{"$nulls":4},"3.5 Caveats3.6 Summary; 3.7 References; 4 The Biophore Concept; 4.1 Introduction; 4.2 Methodology for Pharmacophore Detection and Searching; 4.2.1 Definition of Pharmacophoric Groups; 4.2.2 Ligand-based Methods for Pharmacophore Perception; 4.2.3 Protein Structure-based Pharmacophore Perception; 4.2.4 Methods for Pharmacophore Searching; 4.3 Pharmacophore Fingerprints; 4.4 Applications of the Biophore Concept; 4.4.1 Lead Generation; 4.4.2 Multi-pharmacophore Descriptors in Diversity Analysis and Library Design; 4.4.3 Structure-based Design; 4.5 The Biophore Concept in ADME Prediction"]
[{"$nulls":4},"4.6 Summary"]
[null,null,null,"Sommario/riassunto","The lock-and-key principle formulated by Emil Fischer as early as the end of the 19th century has still not lost any of its significance for the life sciences. The basic aspects of ligand-protein interaction may be summarized under the term 'molecular recognition' and concern the specificity as well as stability of ligand binding. Molecular recognition is thus a central topic in the development of active substances, since stability and specificity determine whether a substance can be used as a drug. Nowadays, computer-aided prediction and intelligent molecular design make a large contributio"]