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[null,"1.","Record Nr.",null,"UNINA9910459557003321"]
[null,null,"Autore",null,"Kimmelman Jonathan"]
[null,null,"Titolo",null,"Gene transfer and the ethics of first-in-human research : lost in translation / / Jonathan Kimmelman [[electronic resource]]"]
[null,null,"Pubbl/distr/stampa",null,"Cambridge : , : Cambridge University Press, , 2010"]
[null,null,"ISBN",null,"0-511-84765-3"]
[{"$nulls":4},"1-107-20737-1"]
[{"$nulls":4},"0-511-64185-0"]
[{"$nulls":4},"0-511-63941-4"]
[{"$nulls":4},"0-511-64049-8"]
[{"$nulls":4},"0-511-63834-5"]
[{"$nulls":4},"0-511-64236-9"]
[null,null,"Descrizione fisica",null,"1 online resource (xi, 205 pages) : digital, PDF file(s)"]
[null,null,"Disciplina",null,"615.8/95"]
[null,null,"Soggetti",null,"Gene therapy - Moral and ethical aspects"]
[{"$nulls":4},"Clinical trials - Moral and ethical aspects"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Title from publisher's bibliographic system (viewed on 05 Oct 2015)."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Introduction: gene transfer lost in translation -- What is gene transfer? -- Safety, values, and legitimacy: the protean nature of risk in translational trials -- Taming uncertainty: risk and gene-transfer clinical research -- Succor or suckers? Benefit, risk, and the therapeutic misconception -- Looking backward: a model value for translational trials -- The chasm: the ethics of initiating first-in-human clinical trials -- Tropic of cancers: gene transfer in resource-poor settings -- Great expectations and hard times: expectation management in gene transfer -- Something in the sight adjusts itself: conclusions."]
[null,null,null,"Sommario/riassunto","Human gene transfer is widely regarded as one of the most promising technologies for the treatment of a variety of disorders, but it presents practitioners with a variety of difficult ethical questions. Gene Transfer and the Ethics of First-in-Human Research examines the ethical and policy dimensions of testing interventions in human beings for the first time. The book discusses the difficult ethical challenges that arise from attempting to translate laboratory discoveries into clinical applications. These range from which available techniques to use, when to initiate human testing, questions of consent, expectation in public arenas, how "]
[{"$nulls":4},"to define acceptable risk, and the inclusion of vulnerable or disadvantaged subjects in early phase trials. This book is relevant to ethicists, legal practitioners, policy makers, geneticists and clinicians involved in clinical trials of new medical interventions."]
[null,"2.","Record Nr.",null,"UNINA9910798030403321"]
[null,null,"Titolo",null,"Advances in genome science . Volume 4 Genes in health and disease / / editor, Atta-ur-Rahman, FRS, Kings College, University of Cambridge, Cambridge, UK"]
[null,null,"Pubbl/distr/stampa",null,"Sharjah : , : Bentham Science Publishers Limited, , [2016]"]
[{"$nulls":4},"©2016"]
[null,null,"ISBN",null,"1-68108-173-3"]
[null,null,"Descrizione fisica",null,"1 online resource (216 p.)"]
[null,null,"Soggetti",null,"Genomes"]
[{"$nulls":4},"Microbial genomes"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Includes index."]
[null,null,"Nota di contenuto",null,"Cover; Title; EUL; Preface; LOC; Chapter 01; Chapter 02; Chapter 03; Chapter 04; Chapter 05; Chapter 06; Chapter 07; Chapter 08; Index; Back Cover"]