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[null,"1.","Record Nr.",null,"UNINA9910459136803321"]
[null,null,"Titolo",null,"Handbook of adaptive designs in pharmaceutical and clinical development / / edited by Annpey Pong, Shein-Chung Chow"]
[null,null,"Pubbl/distr/stampa",null,"Boca Raton : , : CRC Press, , 2011"]
[null,null,"ISBN",null,"0-429-13066-X"]
[{"$nulls":4},"1-283-00453-4"]
[{"$nulls":4},"9786613004536"]
[{"$nulls":4},"1-4398-1017-6"]
[null,null,"Descrizione fisica",null,"1 online resource (475 p.)"]
[null,null,"Disciplina",null,"615.5072/4"]
[null,null,"Soggetti",null,"Clinical trials"]
[{"$nulls":4},"Drugs - Research - Methodology"]
[{"$nulls":4},"Electronic books."]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Front cover; Contents; Preface; Editors; Contributors; Chapter 1. Overview of Adaptive Design Methods in Clinical Trials; Chapter 2. Fundamental Theory of Adaptive Designs with Unplanned Design Change in Clinical Trials with Blinded Data; Chapter 3. Bayesian Approach for Adaptive Design; Chapter 4. The Impact of Protocol Amendments in Adaptive Trial Designs; Chapter 5. From Group Sequential to Adaptive Designs; Chapter 6. Determining Sample Size for Classical Designs; Chapter 7. Sample Size Reestimation Design with Applications in Clinical Trials"]
[{"$nulls":4},"Chapter 8. Adaptive Interim Analyses in Clinical TrialsChapter 9. Classical Dose-Finding Trial; Chapter 10. Improving Dose-Finding: A Philosophic View; Chapter 11. Adaptive Dose-Ranging Studies; Chapter 12. Seamless Phase I/II Designs; Chapter 13. Phase II/III Seamless Designs; Chapter 14. Sample Size Estimation/Allocation for Two-Stage Seamless Adaptive Trial Designs; Chapter 15. Optimal Response-Adaptive Randomization for Clinical Trials; Chapter 16. Hypothesis-Adaptive Design; Chapter 17. Treatment Adaptive Allocations in Randomized Clinical Trials: An Overview"]
[{"$nulls":4},"Chapter 18. Integration of Predictive Biomarker Diagnostics into Clinical Trials for New Drug DevelopmentChapter 19. Clinical Strategy for Study Endpoint Selection; Chapter 20. Adaptive Infrastructure; Chapter 21. "]
[{"$nulls":4},"Independent Data Monitoring Committees; Chapter 22. Targeted Clinical Trials; Chapter 23. Functional Genome-Wide Association Studies of Longitudinal Traits; Chapter 24. Adaptive Trial Simulation; Chapter 25. Efficiency of Adaptive Designs; Chapter 26. Case Studies in Adaptive Design; Chapter 27. Good Practices for Adaptive Clinical Trials; Back cover"]
[null,null,null,"Sommario/riassunto","This comprehensive guide offers a unified presentation of the principles and methodologies in adaptive design and analysis. It gives a well-balanced summary of current regulatory perspectives and recently developed statistical methods in this area. The handbook provides some insight regarding early phase and later phase adaptive designs. With a focus on the implementation of adaptive methods in clinical trials, it introduces the concepts of role, responsibility, function, and activity of a data safety monitoring board (DSMB) when applying these methods. Other important topics covered in detail include regulatory perspectives and logistics issues in applying adaptive design methods--Provided by publisher."]
[null,"2.","Record Nr.",null,"UNISANNIOUFI0083546"]
[null,null,"Autore",null,"Coriasso, Renato"]
[null,null,"Titolo",null,"Il sindacato elettrici della CGIL, 1945-1970 : contributi per una storia sociale / Renato Coriasso ; presentazione Luciano Lama ; prefazione Giorgio Bucci ; introduzione Giulio Sapelli"]
[null,null,"Pubbl/distr/stampa",null,"Roma, : Ediesse, �1985?]"]
[null,null,"Descrizione fisica",null,"XVI, 915 p. ; 22 cm."]
[null,null,"Collana",null,"Storie e testimonianze"]
[null,null,"Classificazione",null,"IT/X436.0"]
[null,null,"Disciplina",null,"331.88"]
[{"$nulls":4},"331.88113337932"]
[{"$nulls":4},"331.88121310945"]
[{"$nulls":4},"331.88330945"]
[null,null,"Soggetti",null,"Federazione italiana dipendenti aziende elettriche - Storia"]
[{"$nulls":4},"Lavoratori dell'industria elettrica - Organizzazione sindacale - Italia - 1945-1970"]
[null,null,"Collocazione",null,"POZZO LIB.ECON MON                7014"]
[null,null,"Lingua di pubblicazione",null,"Italiano"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]