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[null,"1.","Record Nr.",null,"UNINA9910459023403321"]
[null,null,"Autore",null,"Kisaalita William Ssempa <1953, >"]
[null,null,"Titolo",null,"3D cell-based biosensors in drug discovery programs : microtissue engineering for high throughput screening / / William S. Kisaalita"]
[null,null,"Pubbl/distr/stampa",null,"Boca Raton [Fla.] : , : CRC Press, , 2010"]
[null,null,"ISBN",null,"0-429-14677-9"]
[{"$nulls":4},"1-4200-7350-8"]
[null,null,"Descrizione fisica",null,"1 online resource (392 p.)"]
[null,null,"Disciplina",null,"615/.19"]
[null,null,"Soggetti",null,"Pharmaceutical biotechnology"]
[{"$nulls":4},"Biosensors"]
[{"$nulls":4},"High throughput screening (Drug development)"]
[{"$nulls":4},"Electronic books."]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Front Cover; Dedication; Contents; Preface; Author; Part I. Introduction; Chapter 1. Biosensors and Bioassays; Chapter 2. Target-Driven Drug Discovery; Part II. 3D versus 2D Cultures; Chapter 3. Comparative Transcriptional Profiling and Proteomics; Chapter 4. Comparative Structure and Function; Part III. Emerging Design Principles; Chapter 5. Chemical Microenvironmental Factors; Chapter 6. Spatial and Temporal Microenvironmental Factors; Chapter 7. Material Physical Property and Force Microenvironmental Factors; Chapter 8. Proteomics as a Promising Tool in the Search for 3D Biomarkers"]
[{"$nulls":4},"Chapter 9. Readout Present and Near FutureChapter 10. Ready-to-Use Commercial 3D Plates; Part IV. Technology Deployment Challenges and Opportunities; Chapter 11. Challenges to Adopting 3D Cultures in HTS Programs; Chapter 12. Cases for 3D Cultures in Drug Discovery; Chapter 13. Ideal Case Study Design; Appendix A: Patents for 3D Scaffolds; Appendix B: Current Drug Targets; Appendix C: Popular Cell Lines in Drug Discovery; Appendix D: Stem Cells in Drug Discovery; Back Cover"]
[null,null,null,"Sommario/riassunto","This book is based upon cutting-edge research conducted in the authors lab (Cellular Bioengineering), which over the past decade has developed a number of sophisticated techniques to facilitate use of 3D cell based assays or biosensors. This book uses data from peer-reviewed publications to conclusively justify use of 3D cell cultures in "]
[{"$nulls":4},"cell-based biosensors (assays) for (HTS). The majority of assays performed in accelerated drug discovery processes are biochemical in nature, but there is a growing demand for live cell-based assays. Unlike biochemical ones, cellular assays are functional approximations of in vivo biological conditions and can provide more biologically relevant information--Provided by publisher."]