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[null,"1.","Record Nr.",null,"UNINA9910457980403321"]
[null,null,"Autore",null,"Nicholls David G"]
[null,null,"Titolo",null,"Bioenergetics 3 [[electronic resource] /] / David G. Nicholls, Stuart J. Ferguson"]
[null,null,"Pubbl/distr/stampa",null,"San Diego, Calif., : Academic Press, c2002"]
[null,null,"ISBN",null,"1-281-03340-5"]
[{"$nulls":4},"9786611033408"]
[{"$nulls":4},"0-08-052793-0"]
[null,null,"Edizione",null,"[[3rd ed.].]"]
[null,null,"Descrizione fisica",null,"1 online resource (331 p.)"]
[null,null,"Disciplina",null,"572/.43"]
[null,null,"Soggetti",null,"Bioenergetics"]
[{"$nulls":4},"Biological transport, Active"]
[{"$nulls":4},"Electronic books."]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references (p. [271]-281) and index."]
[null,null,"Nota di contenuto",null,"Front Cover; Bioenergetics 3; Copyright Page; CONTENTS; Preface; Note to the reader; Glossary; CHAPTER 1. CHEMIOSMOTIC ENERGY TRANSDUCTION; 1.1 Introduction; 1.2 The chemiosmotic theory: fundamentals; 1.3 The basic morphology of energy-transducing membranes; 1.4 Overview; CHAPTER 2. ION TRANSPORT ACROSS ENERGY-CONSERVING MEMBRANES; 2.1 Introduction; 2.2 The classification of ion transport; 2.3 Bilayer-mediated transport; 2.4 Protein-catalysed transport; 2.5 Swelling and the co-ordinate movement of ions across membranes; CHAPTER 3. QUANTITATIVE BIOENERGETICS: THE MEASUREMENT OF DRIVING FORCES"]
[{"$nulls":4},"3.1 Introduction3.2 Gibbs energy and displacement from equilibrium; 3.3 Oxidation-reduction (redox) potentials; 3.4 Ion electrochemical potential differences; 3.5 Photons; 3.6 Bioenergetic interconversions and thermodynamic constraints on their stoichiometries; 3.7 The equilibrium distributions of ions, weak acids and weak bases; 3.8 Membrane potentials, diffusion potentials, Donnan potentials and surface potentials; CHAPTER 4. THE CHEMIOSMOTIC PROTON CIRCUIT; 4.1 Introduction; 4.2 The measurement of protonmotive force; 4.3 The stoichiometry of proton extrusion by the respiratory chain"]
[{"$nulls":4},"4.4 The stoichiometry of proton uptake by the ATP synthase4.5 Proton current and respiratory control; 4.6 Proton conductance; 4.7 Mitochondria1 respiration rate and metabolic control analysis; 4.8 "]
[{"$nulls":4},"Overall parameters of energy transduction; 4.9 Reversed electron transfer and the proton circuit driven by ATP hydrolysis; 4.10 ATP synthesis driven by an artificial protonmotive force; 4.11 Kinetic competence of Δp in the proton circuit; 4.12 Light-dependent ATP synthesis by bovine heart ATP synthase; CHAPTER 5. RESPIRATORY CHAINS; 5.1 Introduction"]
[{"$nulls":4},"5.2 Components of the mitochondria1 respiratory chain5.3 The sequence of redox carriers in the respiratory chain; 5.4 The mechanism of electron transfer; 5.5 Proton translocation by the respiratory chain: 'loops', ' conformational pumps' or both?; 5.6 Complex I (NADH-UQ oxidoreductase); 5.7 Delivering electrons to ubiquinone without proton translocation; 5.8 Ubiquinone and complex III (bc1 or UQ-CYT c oxidoreductase); 5.9 Cytochrome c and complex IV (cytochrome c oxidase;  ferrocytochrome c: O2 oxidoreductase)"]
[{"$nulls":4},"5.10 Overall proton and charge movements catalysed by the respiratory chain: correlation with the P/O ratio5.11 Superoxide production by complexes I and III; 5.12 Oxidative stress; 5.13 The nicotinamide nucleotide transhydrogenase; 5.14 Electron transport in mitochondria of non-mammalian cells; 5.15 Bacterial respiratory chains; CHAPTER 6. PHOTOSYNTHETIC GENERATORS OF PROTONMOTIVE FORCE; 6.1 Introduction; 6.2 The light reaction of photosynthesis in Rhodobacter sphaeroides and related organisms; 6.3 The generation by illumination or respiration of Δp in photosynthetic bacteria"]
[{"$nulls":4},"6.4 The electron-transfer and light-capture pathway in green plants and algae"]
[null,null,null,"Sommario/riassunto","This new edition of Bioenergetics presents a clear and up-to-date explanation of the chemiosmotic theory and covers mitochondria, bacteria, and chloroplasts. It takes account of the many newly determined structures, such as ATP synthase and the two photosystems of photosynthesis, that provide molecular insight into chemiosmotic energy transduction. This edition includes additional color figures of protein structures and many newly drawn illustrations designed to enable the reader to grasp the fundamental insights that are derived from knowing the structure. Every chapter has been extens"]
[null,"2.","Record Nr.",null,"UNINA9910557526003321"]
[null,null,"Autore",null,"Fioravanti Antonella"]
[null,null,"Titolo",null,"Crosstalk between MicroRNA and Oxidative Stress in Physiology and Pathology"]
[null,null,"Pubbl/distr/stampa",null,"Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020"]
[null,null,"Descrizione fisica",null,"1 online resource (320 p.)"]
[null,null,"Soggetti",null,"Medicine and Nursing"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Sommario/riassunto","MicroRNAs (miRNAs) are small noncoding RNAs that are 19-24 nucleotides in length, following maturation. Recent evidence has demonstrated their key role as post-transcriptional regulators of gene expression through the binding of specific sequences within target messenger RNA (mRNA). miRNAs are involved in the synthesis of a very large number of proteins, and it is speculated that they could regulate up to 30% of the human genome. They control virtually every cellular process and are essential for animal development, cell differentiation, and homeostasis. Altered miRNA expression has been linked to such pathological events as inflammatory, degenerative, or autoimmune processes and have been associated with several diseases, including cancer, cardiovascular diseases, diabetes mellitus, and rheumatic and neurological disorders. Recently, miRNAs have been found in many different biological fluids, and this observation suggests the potential of miRNAs as new candidate biomarkers for diagnosis, classification, prognosis, and responsiveness in the treatment of different pathological conditions. Furthermore, the development of therapeutic strategies that involve either restoring or repressing miRNAs expression and activity has attracted much attention. Significant progress has been made in the systems for delivery of miRNAs, even if substantial improvements in this area are still necessary. Although they have been extensively studied, a number of interesting questions regarding the physiological and pathological role of miRNAs have been postulated, and their potential diagnostic and therapeutic role remain yet unanswered. Reactive oxygen species (ROS) are free radical-"]
[{"$nulls":4},"containing oxygen molecules derived from cellular oxidative metabolism, including enzyme activities and mitochondrial respiration, and play a pivotal role in many cellular functions. Whereas ROS are essential for normal cellular processes, their aberrant production, or failure of the capacity to scavenge excessive ROS, induces an altered redox status with excessive synthesis of free radicals, leading to an imbalance in the redox environment of the cell. The loss of normal ROS levels causes lipid, protein, and DNA damage, which contribute to the development of various pathologies including neurological disorders, rheumatic and cardiovascular diseases, diabetes, and cancer. Increasing evidence highlights that there is crosstalk between miRNAs and components of redox signaling, even if this complex and the characteristics of mutual interaction need to be amply elucidated. Hence, both miRNAs and oxidative stress are involved in the multifactorial development and progression of acute and chronic diseases by influencing numerous signaling and metabolic pathways. The Special Issue entitled \"Crosstalk between MicroRNA and Oxidative Stress in Physiology and Pathology\" of the International Journal of Molecular Sciences includes original articles and reviews that provide new insights into the interaction between miRNAs and oxidative stress under normal and pathological conditions which can assist in the development of new therapeutic strategies. Finally, I would like to thank all the authors for their excellent contribution. I hope this Special Issue will provide readers with updated knowledge about the role of miRNAs and oxidative stress in physiology and pathology."]