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[null,"1.","Record Nr.",null,"UNINA9910455572103321"]
[null,null,"Titolo",null,"Perspectives on vasopressin [[electronic resource] /] / editor, John Francis Laycock"]
[null,null,"Pubbl/distr/stampa",null,"London, : Imperial College Press, c2010"]
[null,null,"ISBN",null,"1-908978-64-3"]
[{"$nulls":4},"1-282-75980-9"]
[{"$nulls":4},"9786612759802"]
[{"$nulls":4},"1-84816-295-2"]
[null,null,"Descrizione fisica",null,"1 online resource (357 p.)"]
[null,null,"Disciplina",null,"612.492"]
[null,null,"Soggetti",null,"Vasopressin"]
[{"$nulls":4},"Vasopressin - Physiological effect"]
[{"$nulls":4},"Electronic books."]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Contents; Preface; Chapter 1. Introduction to Vasopressin (John Laycock); 1. Brief Historical Perspective; 2. General Development, Anatomy and Structure of the Neurohypophysial System; 3. Synthesis, Storage and Release of Neurohypophysial Hormones; 4. Vasopressin Assays; 5. Physiological Actions; 6. Receptors and Mechanisms of Action; 7. Circulation and Metabolism; 8. Control of Release of Vasopressin; 9. Clinical Aspects of Vasopressin; 10. Conclusion; Bibliography; Chapter 2. Comparative and Evolutionary Aspects of Vasopressin  (Jacques Hanoune); 1. Introduction"]
[{"$nulls":4},"2. Evolutionary Aspects of the Vasopressin Family3. Evolutionary Aspects of the Vasopressin Receptor Family; 4. Evolutionary Aspects of the Aquaporin Family; 5. Conclusion; Bibliography; Chapter 3. The Neurohypophysial System: Synthesis and Metabolism of Vasopressin (Jacques Hanoune); 1. Developmental Aspects of the Endocrine Hypothalamus; 2. Biosynthesis; a) Gene structure; b) Processing of the mature peptide; 3. Control of Vasopressin Secretion; a) Control by extracellular osmolality and volaemia; b) Additional factors ; 4. Extra-hypothalamic Expression of Vasopressin; a) Adrenal medulla"]
[{"$nulls":4},"b) Testisc) Blood vessels and heart; d) Other organs; 5. Peripheral Degradation and Metabolic Clearance; Bibliography; Chapter 4. Vasopressin Receptors, the Signalling Cascade and Mechanisms of "]
[{"$nulls":4},"Action (Jacques Hanoune); 1. Introduction: A Short Historical Survey of Vasopressin Receptors; 2. Pharmacological Characterization of the Vasopressin Receptors; 3. Biochemical Characterization of the Vasopressin Receptors; 4. Tissue Expression; a) V1a receptor; b) V1b (V3) receptor; c) V2 receptor; 5. Vasopressin Receptors and G Proteins: An Overview; 6. Structure of the Vasopressin Receptors"]
[{"$nulls":4},"a) General featuresb) Modelling of vasopressin receptors; 7. Structural Basis of the Receptor-Ligand Interaction; a) Binding of agonists; b) Binding of antagonists; 8. Domains Responsible for G Protein-Coupling Selectivity; 9. Dimerization of Receptors; 10. Signalling Pathways; a) The heterotrimeric G protein; b) The cyclic AMP pathway; c) The calcium/phosphatidyl inositol pathway; d) The V2 receptor pathway; e) The V1a receptor pathway; f ) The V1b receptor pathway; g) The proteomic approach; 11. Pre- and Post-transcriptional Regulation of Vasopressin Receptor Expression"]
[{"$nulls":4},"12. Downregulation of Vasopressin Receptors: Desensitization and Internalization13. Are There Other Vasopressin Receptors?; Bibliography; Chapter 5. Pharmacology of the Vasopressin Receptors (Jacques Hanoune); 1. Introduction; 2. Radio-labelled Ligands; 3. Pharmacology of the Vasopressin V1a Receptor; 4. Pharmacology of the Vasopressin V1b Receptor; 5. Pharmacology of the Vasopressin V2 Receptor; 6. Mixed Vasopressin V1a/V2 Receptor Antagonists; 7. Inter-species and Inter-organ Variability; 8. Conclusion; Bibliography; Chapter 6. Vasopressin and Its Renal Effects (John Laycock)"]
[{"$nulls":4},"1. Introduction"]
[null,null,null,"Sommario/riassunto","Vasopressin is a hormone which has an increasingly important profile. Not only does it play a physiologically significant role in renal water regulation but it also has other renal actions and plays a role in overall cardiovascular control. Even more interesting is the recent growing interest in its potential effects on the brain, notably its influence on specific behaviours.  This monograph about the polypeptide vasopressin covers all aspects relating to the production, control of release, and actions of this molecule within the body, including its roles as a hormone and as a central neurotr"]