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[null,"1.","Record Nr.",null,"UNINA9910455447303321"]
[null,null,"Titolo",null,"Pharmacokinetics in risk assessment [[electronic resource] /] / Subcommittee on Disinfectants and Disinfectant By-Products, Safe Drinking Water Committee, Board on Toxicology and Environmental Health Hazards, Assembly of Life Sciences, National Research Council"]
[null,null,"Pubbl/distr/stampa",null,"Washington, D.C., : National Academy Press, 1987"]
[null,null,"ISBN",null,"1-280-22160-7"]
[{"$nulls":4},"9786610221608"]
[{"$nulls":4},"0-309-55769-0"]
[{"$nulls":4},"0-585-15539-9"]
[null,null,"Descrizione fisica",null,"1 online resource (512 p.)"]
[null,null,"Collana",null,"Drinking water and health ; ; v.8"]
[null,null,"Disciplina",null,"333.9122"]
[null,null,"Soggetti",null,"Drinking water - Contamination - United States"]
[{"$nulls":4},"Drinking water - Contamination"]
[{"$nulls":4},"Drinking water - Health aspects - United States"]
[{"$nulls":4},"Drinking water - Health aspects"]
[{"$nulls":4},"Water - Pollution - Toxicology"]
[{"$nulls":4},"Electronic books."]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,"Nota di contenuto",null,"\"\"Pharmacokinetics in Risk Assessment\"\"; \"\"Copyright\"\"; \"\"PREFACE\"\"; \"\"Contents\"\"; \"\"PART I INTRODUCTION: THE PROBLEM AND AN APPROACH \"\"; \"\"Risk Assessment: Historical Perspectives\"\"; \"\"References\"\"; \"\"Tissue Dosimetry in Risk Assessment, or What's the Problem Here Anyway?\"\"; \"\"INTRODUCTION\"\"; \"\"A DOSE OF WHAT?\"\"; \"\"ISN'T THIS VOLUME ABOUT PHARMACOKINETICS?\"\"; \"\"GENOTOXIC CARCINOGENS\"\"; \"\"PARENT CHEMICAL\"\"; \"\"STABLE METABOLITES\"\"; \"\"REACTIVE, NONISOLATABLE METABOLITES\"\"; \"\"INTERCALATING AGENTS\"\"; \"\"EPIGENETIC CARCINOGENS\"\"; \"\"SUMMARY\"\"; \"\"References\"\"; \"\"PART II MATHEMATICAL MODELING \"\""]
[{"$nulls":4},"\"\"Modeling: An Introduction\"\"\"\"References\"\"; \"\"Physiologically Based Pharmacokinetic Modeling\"\"; \"\"INTRODUCTION\"\"; \"\"BIOLOGICAL BASIS OF PHYSIOLOGICAL PHARMACOKINETICS\"\"; \"\"DEVELOPMENT OF MODELS\"\"; \"\"CHOICE OF COMPARTMENTS\"\"; \"\"BASIC MASS BALANCES\"\"; \"\"Mass Balance: Blood Pool\"\"; \"\"Mass Balance: Tissue Region i\"\"; \"\"SIMPLIFICATIONS OF MASS BALANCES\"\"; \"\"Examples\"\"; \"\"DISCUSSION\"\"; "]
[{"$nulls":4},"\"\"FUTURE RESEARCH NEEDS\"\"; \"\"References\"\"; \"\"PART III GENERALIZATIONS AND EXTRAPOLATIONS \"\"; \"\"Allometry: Body Size Constraints in Animal Design\"\"; \"\"INTRODUCTION\"\"; \"\"SIZE, DESIGN, AND PHARMACOKINETICS\"\""]
[{"$nulls":4},"\"\"Aerobic Energetics of Muscle In Vivo\"\"\"\"Conflict of Physiological and Chronological Time\"\"; \"\"Species Extrapolations, Physiological Time, and Pharmacokinetics\"\"; \"\"CONCLUSIONS\"\"; \"\"SUMMARY\"\"; \"\"References\"\"; \"\"Prediction of In Vivo Parameters of Drug Metabolism and Distribution from In Vitro Studies\"\"; \"\"IN VITRO PREDICTION OF IN VIVO DRUG METABOLISM\"\"; \"\"IN VITRO PREDICTION OF IN VIVO DRUG BINDING AND DISTRIBUTION\"\"; \"\"CONCLUSION\"\"; \"\"References\"\"; \"\"Dose, Species, and Route Extrapolation: General Aspects\"\"; \"\"DIFFERENT PROBLEMS AND OBJECTIVES, DIFFERENT MODELS\"\"; \"\"Different Mechanisms\"\""]
[{"$nulls":4},"\"\"GENERAL PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELS\"\"\"\"Simplification of Models\"\"; \"\"Rates of Formation of Complexes\"\"; \"\"Diffusional Barriers and Modified Fick's Law\"\"; \"\"Simple PB-PK Models\"\"; \"\"Basic Parameters fu and R\"\"; \"\"Nonlinear Kinetics and Lost Concepts\"\"; \"\"INTERFACE BETWEEN PB-PK MODELS AND CLEARANCES\"\"; \"\"Organ Availabilities (F), Extraction Ratios (E), and Clearances (CL)\"\"; \"\"Physiologically Based Linear Compartmental Pharmacokinetic Models\"\"; \"\"Validity of the Assumption of Virtual Steady State\"\"; \"\"Calculation of Other Compartmental Model Parameters\"\""]
[{"$nulls":4},"\"\"Approximations of Terminal Half-Lives\"\"\"\"Approximate Time Required to Approach Steady State\"\"; \"\"LINEAR PHARMACOKINETIC SYSTEMS\"\"; \"\"Total Body Clearance\"\"; \"\"Importance of the Unbound Concentration of Substances\"\"; \"\"Classification of Organs;  Routes of Administration\"\"; \"\"Non-First-Pass, Nonelimination Organs\"\"; \"\"Range of Maximum and Minimum Unbound Concentrations in Nonelimination Organs and Repetitive Administration\"\"; \"\"Non-First-Pass, Elimination Organs\"\"; \"\"FIRST-PASS, NONELIMINATION ORGANS\"\"; \"\"First-Pass, Elimination Organs\"\"; \"\"ROUTE-TO-ROUTE EXTRAPOLATION\"\""]
[{"$nulls":4},"\"\"Lungs and Skin Administration\"\""]