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[null,"1.","Record Nr.",null,"UNISOBSOBE00017273"]
[null,null,"Titolo",null,"Jane Austen : oggi e ieri / a cura di Beatrice Battaglia"]
[null,null,"Pubbl/distr/stampa",null,"Ravenna : Longo, 2002"]
[null,null,"ISBN",null,"8880633481"]
[null,null,"Descrizione fisica",null,"222 p. : ritr. ; 24 cm"]
[null,null,"Collana",null,"<Il >portico ; 127"]
[null,null,"Lingua di pubblicazione",null,"Italiano"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,"2.","Record Nr.",null,"UNINA9910452811503321"]
[null,null,"Titolo",null,"Arms control [[electronic resource] ] : history, theory, and policy / / Robert E. Williams Jr. and Paul R. Viotti, editors"]
[null,null,"Pubbl/distr/stampa",null,"Santa Barbara, CA, : Praeger, 2012"]
[null,null,"ISBN",null,"1-280-77947-0"]
[{"$nulls":4},"9786613689863"]
[{"$nulls":4},"0-275-99821-5"]
[null,null,"Descrizione fisica",null,"1 online resource (805 p.)"]
[null,null,"Collana",null,"Praeger security international"]
[null,null,"Disciplina",null,"327.1/74"]
[null,null,"Soggetti",null,"Arms control"]
[{"$nulls":4},"Arms control - History"]
[{"$nulls":4},"Security, International"]
[{"$nulls":4},"Electronic books."]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Includes index."]
[null,null,"Nota di contenuto",null,"Cover; Arms Control; Title; Copyright; Dedication; Contents; Acknowledgments; Part I: An Introduction to Arms Control; Part I: Weapons of Mass Destruction; 1 Introduction: Arms Control's Third Era; 1 Arms Control: Biological and Chemical Weapons; 2 A Template for Understanding Arms Control; 3 Elements of a General Theory of Arms Control; 4 Arms Control and International Law; Part II: Philosophical Foundations; 5 The Philosophical Underpinnings of Arms Control; 6 Creative Spirit: The Self as a Force for Human Survival; 7 Deterrence, Nonproliferation, and Disarmament: The Nuclear Conundrum"]
[{"$nulls":4},"Part III: Arms Control and the Social Sciences8 Arms Control in the Human Security Paradigm; 9 Conflict Resolution; 10 Anthropology and Arms Control; 11 Approaches to Arms Control Simulations: A Primer on Game Theory, Agent-Based Modeling, and Landscape Dynamics; Part IV: Arms Control and NGOs; 12 NGOs, Social Movements, and Arms Control; 13 NGOs and Arms Control Processes; Part V: Arms Control-Historical Perspectives; 14 Arms Control and Nuclear Weapons; 15 Strategic Arms Control since World War II; 16 The Perils of Arms Control: The Lessons of Naval Arms Limitation during the Interwar Years"]
[{"$nulls":4},"17 The Convention on Cluster Munitions18 The Control of Landmines and Other Explosive Remnants of War; Appendix: Biographical "]
[{"$nulls":4},"Sketches; Bertha von Suttner; Woodrow Wilson; Nicholas II; Bertrand Russell; J. Robert Oppenheimer; Thomas C. Schelling; Andrei Sakharov; Hedley Bull; Helen Caldicott; Mohamed ElBaradei; Randall Forsberg; Jody Williams; Mikhail Gorbachev; Index; About the Contributors; Arms Control; Title; Copyright; Dedication; Contents; 2 Nuclear Proliferation; 3 Rethinking Our Nuclear Weapons Proliferation Threats and Solutions"]
[{"$nulls":4},"4 Nuclear Arms Control, Nonproliferation, and Missile Defenses5 Conventional and Nuclear Weapons Proliferation in East Asia; 6 Tactical Nuclear Weapons in Europe: A Further Step in the Arms Control Agenda?; 7 Conventional Arms Control in the Context of European Security; 8 Arms Control and European Security during the Cold War; 9 Israel, Iran, and the Arms Control Paradox in the Middle East; 10 A History of the Iranian Nuclear Program; Part II: Advanced Technologies-Outer Space and Cyberspace; 11 Keeping a Lid on Space Weaponization: The Prospects for an Arms Control Regime in Space"]
[{"$nulls":4},"12 Dilemmas of Arms Control and CybersecurityAppendix: Arms Control Treaties; Chemical and Biological Weapons; Geneva Protocol against Using Chemical and Bacteriological Weapons: 1925; Biological Weapons Convention (BWC): 1972; Chemical Weapons Convention (CWC): 1993; Nuclear Weapons Treaties; Treaty on the Non-Proliferation of Nuclear Weapons (NPT): 1968; Intermediate-Range Nuclear Forces (INF) Treaty: 1987; Strategic Arms Reduction Treaty (START I): 1991; Strategic Arms Reduction Treaty II (START II): 1993 and 1997; Comprehensive Nuclear Test Ban Treaty (CTBT): 1996"]
[{"$nulls":4},"Strategic Offensive Reductions Treaty (SORT): 2002"]
[null,null,null,"Sommario/riassunto","Set against a backdrop of terrorism, rogue states, non-conventional warfare, and deteriorating diplomacy, this encyclopedia offers a comprehensive, multidisciplinary, up-to-date reference on the recent history and contemporary practice of arms control and nonproliferation."]
[null,"3.","Record Nr.",null,"UNINA9910136799903321"]
[null,null,"Titolo",null,"Endoplasmic reticulcum and its role in tumor immunity [[electronic resource]  /] / edited by: Paul Eggleton, Marek Michalak and Edwin Bremer"]
[null,null,"Pubbl/distr/stampa",null,"Frontiers Media SA, 2016"]
[{"$nulls":4},"[Lausanne, Italy] : , : Frontiers Media SA, , 2016"]
[{"$nulls":4},"©2016"]
[null,null,"Descrizione fisica",null,"1 online resource (101 pages) : illustrations; digital, PDF file(s)"]
[null,null,"Collana",null,"Frontiers Research Topics"]
[{"$nulls":4},"Frontiers in Oncology"]
[null,null,"Disciplina",null,"571.6/5"]
[null,null,"Soggetti",null,"Endoplasmic reticulum"]
[{"$nulls":4},"Tumors - Immunological aspects"]
[{"$nulls":4},"Immunology"]
[{"$nulls":4},"Oncology"]
[{"$nulls":4},"Endoplasmic Reticulum Stress"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Nota di bibliografia","Includes bibliographical references."]
[null,null,null,"Sommario/riassunto","The endoplasmic reticulum (ER) is an organelle crucial to many cellular functions and processes, including the mounting of T-cell immune responses. Indeed, the ER has a well-established central role in anti-tumor immunity. Perhaps best characterized is the role of the ER in the processing of antigen peptides and the subsequent peptide assembly into MHC class I and II molecules. Such MHC/tumor-derived peptide complexes are pivotal for the correct recognition of altered self or viral peptides and the subsequent clonal expansion of tumor-reactive T-cells. In line with the role of the ER in immunity, tumor-associated mutations in ER proteins, as well as ER protein content and localization can have both deleterious and advantageous effects on anti-tumor immune responses. For instance, loss of function of ER-aminopeptidases, that trim peptides to size for MHC, alter the MHC class I - peptide repertoire thereby critically and negatively affecting T-cell recognition. On the other hand, altered localization of ER proteins can have immune-promoting effects. Specifically, translocation of "]
[{"$nulls":4},"certain ER proteins to the cell surface has been shown to promote anti-tumor T-cell immunity by directing uptake of apoptotic tumor cells to professional antigen presenting cells, thereby facilitating anti-tumor T-cell immunity. These selected examples highlight a diverse and multi-faceted role of the ER in anti-tumor immunity. Molecular biological insights from the past decade have uncovered that ER components may affect tumor immunity and have invoked a variety of follow-up questions. For instance, how and why are ER proteins over-expressed in tumors? How do nucleotide and somatic mutations in ER chaperones/processing machinery affect the MHC/peptide complex and tumor cell immunogenicity? How do ER-proteins translocate to the cell surface? What if any is the potential role of extracellular ER protein in tumor immunotherapy/vaccines, and can they be delivered to the tumor cell surface by photodynamic therapy, anthracyclines or by other means? In this special research topics issue, we welcome basic and clinical research reports covering all aspects of ER proteins in cancer recognition by the immune system, therapy and drug development. We also welcome reports describing new insights into ER stress, signalling and homeostasis in immunogenic cell death in cancer, the effect of parasitic ER proteins on tumour growth, ER protein regulation of angiogenesis. Submission of original research articles, perspective, reviews and topical comments is encouraged. We aim to provide a comprehensive series of articles that will aid our understanding in a new and exiting avenue of tumour immunology and therapeutic development, exploiting a collection of proteins within the ER that are not obvious candidates for immunity to tumors."]