{"text_format":"2","workbook":"xls","n_sheets":1,"sheets":["report2"],"not_rendered":{"charts":0,"images":0,"macros":0,"external_links":1,"defined_names":2,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"run_cost":"one","rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"report2","index":0,"n_rows":40,"n_cols":5,"rows_kept":40,"cut":false,"hidden":false,"merged":[[0,2,0,3],[0,4,0,5],[1,2,1,3],[1,4,1,5],[2,2,2,3],[3,2,3,3],[9,2,9,3],[10,2,10,3],[11,2,11,3],[12,2,12,3],[15,2,15,3],[16,2,16,3],[20,2,20,3],[24,2,24,3],[24,4,24,5],[25,2,25,3],[25,4,25,5],[26,2,26,3],[26,4,26,5],[27,2,27,3],[28,2,28,3],[29,2,29,3],[30,2,30,3],[31,2,31,3],[32,2,32,3],[34,2,34,3],[35,2,35,3],[37,2,37,3]],"flags":["formulas_cached_only"]}
[null,"1.","Record Nr.",null,"UNINA9910450847803321"]
[null,null,"Titolo",null,"Virtual ADMET assessment in target selection and maturation [[electronic resource] /] / edited by B. Testa and L. Turski"]
[null,null,"Pubbl/distr/stampa",null,"Amsterdam ; ; Washington, DC, : IOS Press, c2006"]
[null,null,"ISBN",null,"1-280-81056-4"]
[{"$nulls":4},"9786610810567"]
[{"$nulls":4},"1-4294-6772-X"]
[{"$nulls":4},"1-60750-219-4"]
[{"$nulls":4},"600-00-0604-7"]
[{"$nulls":4},"1-4337-0155-3"]
[null,null,"Descrizione fisica",null,"1 online resource (268 p.)"]
[null,null,"Collana",null,"Solvay Pharmaceuticals Conferences, , 1566-7685 ; ; v. 6"]
[null,null,"Disciplina",null,"615/.190285"]
[null,null,"Soggetti",null,"Drug development - Computer simulation"]
[{"$nulls":4},"Pharmacology"]
[{"$nulls":4},"Electronic books."]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Organized May 11-13th, 2005 in Lucerne, Switzerland."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Preface; List of Contributors; Contents; Conference Preface; The Risky Business of Developing Drugs; Benefits and Limits of in Silico Predictions; Musings on ADME Predictions and Molecular Structure; Lipophilicity: Its Calculation and Application in ADMET Predictions; Interpretation of the Role of the Electrotopological State and Molecular Connectivity Indices in the Prediction of Physical Properties and ADME-Tox Behavior - Case Study: Human Plasma Protein Binding; Molecular Descriptors for Predicting ADMET Properties; Molecular Fields to Assess Recognition Forces and Property Spaces"]
[{"$nulls":4},"Extracting Pharmacophores from Bio-Active MoleculesIn Silico Models for Human Bioavailability; In Silico Models to Predict Brain Uptake; Algorithms to Predict Affinity for Transporters; Predicting Affinity for and Metabolism by Cytochromes P450; Expert Systems to Predict Biotransformation; Expert Systems to Predict Toxicity; From in Vivo to in Vitro/in Silico ADME: Progress and Challenges; Author Index"]
[null,null,null,"Sommario/riassunto","Today, biologists and medicinal chemists realize that there is a strong relationship between pharmacodynamic (what the drug does to the organism) and pharmacokinetic (what the organism does to the drug) "]
[{"$nulls":4},"effects. A significant contributing factor to the evolution in drug discovery was the methodological and technological revolution with the advent of combinatorial chemistry, high-throughput screening and profiling, and in silico prediction of target-based activity and ADMET (absorption, distribution, metabolism, excretion and toxicity) properties. High-throughput screening and in silico methods"]
[null,"2.","Record Nr.",null,"UNINA9910299811803321"]
[null,null,"Autore",null,"Greco Pietro"]
[null,null,"Titolo",null,"Galileo Galilei : the Tuscan Artist / / Pietro Greco"]
[null,null,"Pubbl/distr/stampa",null,"Cham : , : Springer International Publishing : , : Imprint : Springer, , 2018"]
[null,null,"ISBN",null,"3-319-72032-5"]
[null,null,"Edizione",null,"[First edition 2018.]"]
[null,null,"Descrizione fisica",null,"1 online resource (373 pages)"]
[null,null,"Disciplina",null,"520.92"]
[null,null,"Soggetti",null,"Mathematicians - Italy"]
[{"$nulls":4},"Musicians - Italy - Florence"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,"Nota di contenuto",null,"Galileo’s birth -- Music at the time of Vincenzio Galilei -- Vincenzio in Florence -- Galileo in Pisa -- A Novice in Monastery -- Challenging Zarlino -- Return to Pisa -- Galileo meeting Ostilio Ricci -- A young unemployed Mathematician -- Galileo as a literary critic -- Galileo’s first approach to a new method -- Teaching in Pisa -- Galileo as a literary critic and writer -- The best eighteen years of his age -- A Tuscan artist in Padua -- The Nova Star -- A Sidereus Nuncius -- An artists’ warning -- New projects -- Galileo superstar -- Vicisti Galilaee! -- Galileo as a mathematician and philosopher in Florence -- Galileo’s triumph in Rome -- Converting the Church -- A theory of culture -- You cannot prevent humankind from looking at the stars: the Copernican Letters -- They silence him -- Three comets and an Assayer -- The censored masterpiece -- Will to live -- Galileo’s Dialogues and music -- Galileo’s last years -- The Enigma."]
[null,null,null,"Sommario/riassunto","This book is a distinctively original biography of Galileo Galilei, probably the last eclectic genius of the Italian Renaissance, who was not only one of the greatest scientists ever, but also a philosopher, a theologian, and a man of great literary, musical, and artistic talent – “The Tuscan Artist”, as the poet John Milton referred to him. Galileo was exceptional in simultaneously excelling in the Arts, Science, Philosophy, and Theology. These diverse aspects of his life were closely intertwined; indeed, it may be said that he personally demonstrated that human culture is not divisible, but rather one, with a thousand shades. Galileo also represented the bridge between two historical epochs. As the philosopher Tommaso Campanella, a contemporary of "]
[{"$nulls":4},"Galileo, recognized at the time, Galileo was responsible for ushering in a new age, the Modern Age. This book, which is exceptional in the completeness of its coverage, explores all aspects of the life of Galileo, as a Tuscan artist and giant of the Renaissance, in a stimulating and reader-friendly way."]