{"text_format":"2","workbook":"xls","n_sheets":1,"sheets":["report2"],"not_rendered":{"charts":0,"images":0,"macros":0,"external_links":1,"defined_names":2,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"run_cost":"one","rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"report2","index":0,"n_rows":34,"n_cols":5,"rows_kept":34,"cut":false,"hidden":false,"merged":[[0,2,0,3],[0,4,0,5],[1,2,1,3],[1,4,1,5],[2,2,2,3],[3,2,3,3],[8,2,8,3],[9,2,9,3],[10,2,10,3],[11,2,11,3],[14,2,14,3],[15,2,15,3],[19,2,19,3],[23,2,23,3],[23,4,23,5],[24,2,24,3],[24,4,24,5],[25,2,25,3],[25,4,25,5],[26,2,26,3],[27,2,27,3],[28,2,28,3],[29,2,29,3],[30,2,30,3]],"flags":["formulas_cached_only"]}
[null,"1.","Record Nr.",null,"UNINA9910449798203321"]
[null,null,"Titolo",null,"Engaging the world [[electronic resource] ] : the use of empirical research in bioethics and the regulation of biotechnology / / edited by Søren Holm and Monique F. Jonas"]
[null,null,"Pubbl/distr/stampa",null,"Amsterdam ; ; Washington, DC, : IOS Press, c2004"]
[null,null,"ISBN",null,"1-280-50599-0"]
[{"$nulls":4},"9786610505999"]
[{"$nulls":4},"1-4175-9021-1"]
[{"$nulls":4},"600-00-0419-2"]
[{"$nulls":4},"1-60129-424-7"]
[null,null,"Descrizione fisica",null,"1 online resource (166 p.)"]
[null,null,"Collana",null,"Biomedical and health research, , 0929-6743 ; ; v. 58"]
[null,null,"Disciplina",null,"174.957"]
[null,null,"Soggetti",null,"Medical ethics - Research"]
[{"$nulls":4},"Bioethics - Research"]
[{"$nulls":4},"Electronic books."]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Cover; Title page; Preface; Contents; A Defence of Empirical Bioethics; Healthcare and the Habermasian Public Sphere; Putting Empirical Studies in their Place; Can There Be Moral Experts?; What should we do about it? Implications of the Empirical Evidence in Relation to Comprehension and Acceptability of Randomisation; Use and Abuse of Empirical Knowledge in Contemporary Bioethics: A Critical Analysis of Empirical Arguments Employed in the Controversy Surrounding Stem Cell Research; Carol Gilligan and her Different Voice"]
[{"$nulls":4},"Who Should Decide and Why? The Futility of Philosophy, Sociology and Law in Institutionalised Bioethics and the Unwarrantability of Ethics CommitteesEmpirical Investigations of Moral Development; Theory and Methodology of Empirical-Ethical Research; An Empirical Study of the Informed Consent Process of a Clinical Trial; Stimulating Public Debate on the Ethical and Social Issues Raised by the New Genetics; The Use of Computer Simulation and Artificial Intelligence in the Study of Ethical Components of Medical Decision-Making; Conclusion; Author Index"]
[null,null,null,"Sommario/riassunto","Holm (Institute of Medicine, Law, and Bioethics, University of Manchester, UK) and Jonas (Center for Social Ethics and Policy, University of Manchester) gather papers representing the work "]
[{"$nulls":4},"performed as part of the Empirical Methods in Bioethics project sponsored by the European Commission, DG-Research. The papers are mainly concerned with investiga"]
[null,"2.","Record Nr.",null,"UNINA9910220042603321"]
[null,null,"Autore",null,"Matthias P. Mayer"]
[null,null,"Titolo",null,"The HSP70 Molecular Chaperone Machines"]
[null,null,"Pubbl/distr/stampa",null,"Frontiers Media SA, 2017"]
[null,null,"Descrizione fisica",null,"1 online resource (69 p.)"]
[null,null,"Collana",null,"Frontiers Research Topics"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Sommario/riassunto","Members of the HSP70 family form a central hub of the molecular chaperone network, controlling protein homeostasis in prokaryotes and in the ATP-containing compartments of the eukaryotic cells. The heat-inducible form HSPA1A (HSP70), its constitutive cytosolic cognate HSPA8 (Hsc70), its endoplasmic reticulum form HSPA5 (BiP), and its mitochondrial form HSPA9 (Mortalin), as well as the more distantly related HSPHs (HSP110s), make up 1-2 % of the total mass of proteins in human cells. They use the energy of ATP-hydrolysis to prevent and forcefully revert the process of protein misfolding and aggregation during and following various stresses, presumably by working as unfoldases to lift aberrant conformers out of kinetic traps. As such, HSP70s, in cooperation with their J-domain co-chaperones and nucleotide exchange factors (NEFs) and co-disaggregases, form an efficient network of cellular defenses against the accumulation of cytotoxic misfolded protein conformers, which may cause degenerative diseases such as Parkinson's and Alzheimer's disease, diabetes, and aging in general. In addition to their function in repair of stress-induced damage, HSP70s fulfill many housekeeping functions, including assisting the de novo folding and maturation of proteins, driving the translocation of protein precursors across narrow membrane pores into organelles, and by controlling the oligomeric state of key regulator protein complexes involved in signal transduction and vesicular trafficking. For reasons not well understood, HSP70s are also found on the surface of some animal cells, in particular cancer cells where they may serve as specific targets for cancer immunotherapy. Here, we gathered seven mini reviews, each "]
[{"$nulls":4},"presenting a complementary aspect of HSP70's structure and function in bacteria and eukaryotes, under physiological and stressful conditions. These articles highlight how, the various members of this conserved family of molecular chaperones, assisted by their various J-domain and NEF cochaperones and co-disaggregases, harness ATP hydrolysis to perform a great diversity of life-sustaining cellular functions using a similar molecular mechanism."]