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[null,"1.","Record Nr.",null,"UNINA9910449681403321"]
[null,null,"Autore",null,"Clemson David"]
[null,null,"Titolo",null,"Mathematics in the early years / / David Clemson and Wendy Clemson"]
[null,null,"Pubbl/distr/stampa",null,"London ; ; New York : , : Routledge, , 1994"]
[null,null,"ISBN",null,"1-299-47653-8"]
[{"$nulls":4},"1-134-86454-X"]
[{"$nulls":4},"1-280-56269-2"]
[{"$nulls":4},"9786610562695"]
[{"$nulls":4},"0-203-13367-6"]
[null,null,"Descrizione fisica",null,"1 online resource (238 p.)"]
[null,null,"Collana",null,"Teaching and learning in the first three years of school"]
[null,null,"Disciplina",null,"372.7/049"]
[null,null,"Soggetti",null,"Mathematics - Study and teaching (Primary)"]
[{"$nulls":4},"Electronic books."]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references (p. [213]-218) and indexes."]
[null,null,"Nota di contenuto",null,"Cover; Mathematics in the early years; Copyright; Contents; Illustrations; Editor's preface; Foreword; Acknowledgements; Part I. A context for mathematics; 1. How children learn; 2. Home and school; Part II. The subject mathematics; 3. What mathematics is; 4. The mathematics curriculum; 5. Mathematics and language; Part III. Managing mathematics; 6. School plans; 7. Mathematics in the classroom; Part IV. Mathematics in action; 8. Classroom episodes; Part V. Assessment, record keeping and evaluation; 9. Monitoring progress; 10. Modifying practice; Part VI. In-service education"]
[{"$nulls":4},"11. Workshop ideasBibliography; Author index; Subject index"]
[null,null,null,"Sommario/riassunto","The Clemsons' clear and readable book takes the reader from debates about how children learn and what children know and can do when they start school; through to a discussion of how mathematics can be managed, assessed and evaluated in the school and classroom. Linking these two parts of the book is a section on the subject of mathematics itself, from which the non-specialist reader can gain a view of what mathematics is, what needs to be thought about in planning and offering a curriculum and the special dilemmas faced in teaching and learning mathematics as a subject. A bank of case studies"]
[null,"2.","Record Nr.",null,"UNISA996217063403316"]
[null,null,"Titolo",null,"Advanced computer-assisted techniques in drug discovery [[electronic resource] /] / edited by Han van de Waterbeemd"]
[null,null,"Pubbl/distr/stampa",null,"Weinheim ; ; New York, : VCH, c1995"]
[null,null,"ISBN",null,"1-281-84288-5"]
[{"$nulls":4},"9786611842888"]
[{"$nulls":4},"3-527-61567-9"]
[{"$nulls":4},"3-527-61566-0"]
[null,null,"Descrizione fisica",null,"1 online resource (367 p.)"]
[null,null,"Collana",null,"Methods and principles in medicinal chemistry ; ; v. 3"]
[null,null,"Disciplina",null,"615.10285"]
[{"$nulls":4},"615.1900285"]
[null,null,"Soggetti",null,"Pharmaceutical chemistry - Data processing"]
[{"$nulls":4},"Drugs - Design - Data processing"]
[{"$nulls":4},"Drugs - Research - Data processing"]
[{"$nulls":4},"QSAR (Biochemistry)"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Advanced Computer- Assisted Techniques in Drug Discovery; Preface; A Personal Foreword; Contents; 1 Introduction; 1.1 3D QSAR; 1.2 Databases; 1.3 Progress in Multivariate Data Analysis; 1.4 Scope of this Book; References; 2 3D QSAR: The Integration of QSAR with Molecular Modeling; 2.1 Chemometrics and Molecular Modeling; 2.1.1 Introduction; 2.1.2 QSAR Methodology using Molecular Modeling and Chemometrics; 2.1.2.1 Search for the Geometric Pharmacophore; 2.1.2.2 Quantitative Correlation between Molecular Properties and Activity; 2.1.2.3 Computer Programs; 2.1.3 Illustrative Examples"]
[{"$nulls":4},"2.1.3.1 Amnesia-Reversal Compounds2.1.3.2 Non-Peptide Angiotensin II Receptor Antagonists; 2.1.3.3 HMG-CoA Reductase Inhibitors; 2.1.3.4 Antagonists at the 5-HT3 Receptor; 2.1.3.5 Polychlorinated Dibenzo-p-dioxins; 2.1.4 Conclusions; References; 2.2 3D QSAR Methods; 2.2.1 Introduction; 2.2.2 3D QSAR of a Series of Calcium Channel Agonists; 2.2.2.1 Molecular Alignment; 2.2.2.2 Charges; 2.2.2.3 Generating 3D Fields; 2.2.2.4 Compilation of GRID Maps; 2.2.2.5 Inclusion of Macroscopic Descriptors with 3D Field Data; 2.2.3 Statistical Analysis; 2.2.3.1 Results of the Analysis"]
[{"$nulls":4},"2.2.3.2 Testing the Model2.2.4 Conclusions; References; 2.3 GOLPE "]
[{"$nulls":4},"Philosophy and Applications in 3D QSAR; 2.3.1 Introduction; 2.3.1.1 3D Molecular Descriptors and Chemometric Tools; 2.3.1.2 Unfolding Three-way Matrices; 2.3.2 The GOLPE Philosophy; 2.3.2.1 Variable Selection; 2.3.3 Applications; 2.3.3.1 PCA on the Target Matrix; 2.3.3.2 PCA on the Probe Matrix; 2.3.3.3 PLS Analysis on the Target Matrix; 2.3.3.4 PLS on Target Matrix as a Strategy to Ascertain the Active Conformation; 2.3.3.5 GOLPE with Different 3D Descriptors; 2.3.4 Conclusions and Perspectives; References"]
[{"$nulls":4},"3 Rational Use of Chemical and Sequence Databases3.1 Molecular Similarity Analysis: Applications in Drug Discovery; 3.1.1 Introduction; 3.1.2 Similarity-Based Compound Selection; 3.1.2.1 Similarity Measures and Neighborhoods; 3.1.2.2 Application of 2D and 3D Similarity Measures; 3.1.2.3 Application of Dissimilarity-Based Compound Selection for Broad Screening; 3.1.3 Structure-Activity Maps (SAMs); 3.1.3.1 A Visual Analogy; 3.1.3.2 Representing Inter-Structure Distances; 3.1.3.3 Structure Maps; 3.1.3.4 Coloring a Structure Map; 3.1.4 Field-Based Similarity Methods"]
[{"$nulls":4},"3.1.4.1 Field-Based Similarity Measures3.1.4.2 Field-Based Molecular Superpositions; 3.1.4.3 An Example of Field-Based Fitting: Morphine and Clonidine; 3.1.5 Conclusions; References; 3.2 Clustering of Chemical Structure Databases for Compound Selection; 3.2.1 Introduction; 3.2.2 Review of Clustering Methods; 3.2.2.1 Hierarchical Clustering Methods; 3.2.2.2 Non-Hierarchical Clustering Methods; 3.2.3 Choice of Clustering Method; 3.2.3.1 Computational Requirements; 3.2.3.2 Cluster Shapes; 3.2.3.3 Comparative Studies"]
[{"$nulls":4},"3.2.4 Examples of the Selection of Compounds from Databases by Clustering Techniques"]
[null,null,null,"Sommario/riassunto","The use of powerful computers has revolutionized molecular design and drug discovery. Thoroughly researched and well-structured, this comprehensive handbook covers highly effective and efficient techniques in 3D-QSAR and advanced statistical analysis. The emphasis is on showing users how to apply these methods and avoid costly and time-consuming methodical errors.Topics covered include* combination of statistical methods and molecular modeling tools* rational use of databases* advanced statistical techniques* neural networks and expert systems in molecular design<br"]