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[null,"1.","Record Nr.",null,"UNINA9910800113003321"]
[null,null,"Author",null,"Pörtner Ralf"]
[null,null,"Title",null,"Biopharmaceutical Manufacturing : Progress, Trends and Challenges / / edited by Ralf Pörtner"]
[null,null,"Publication",null,"Cham : , : Springer International Publishing : , : Imprint : Springer, , 2023"]
[null,null,"ISBN",null,"9783031456695"]
[{"$nulls":4},"3031456696"]
[null,null,"Designation of edition ",null,"[1st ed. 2023.]"]
[null,null,"Physical description",null,"1 online resource (497 pages)"]
[null,null,"Series statement",null,"Cell Engineering, , 2542-9515 ; ; 11"]
[null,null,"Dewey",null,"571.6"]
[null,null,"Subjects",null,"Cytology"]
[{"$nulls":4},"Biomedical engineering"]
[{"$nulls":4},"Biotechnology"]
[{"$nulls":4},"Biochemical engineering"]
[{"$nulls":4},"Pharmaceutical chemistry"]
[{"$nulls":4},"Vaccines - Biotechnology"]
[{"$nulls":4},"Biomaterials"]
[{"$nulls":4},"Cell Biology"]
[{"$nulls":4},"Biomedical Engineering and Bioengineering"]
[{"$nulls":4},"Bioprocess Engineering"]
[{"$nulls":4},"Pharmaceutics"]
[{"$nulls":4},"Biomaterials-Vaccines"]
[null,null,"Language",null,"English"]
[null,null,"Format",null,"Language material"]
[null,null,null,"Bibliographic level","Monograph"]
[null,null,"Formatted content note",null,"Part I: Manufacturing of Recombinant Therapeutic Proteins -- Chapter 1. Single-Use Systems in Biopharmaceutical Manufacture: State of the Art and Recent Trends (Jossen et al.) -- Chapter 2. Recent Developments in Bioprocess Monitoring Systems (Rahmatnejad et al.) -- Chapter 3. Advances in Characterization of Industrial Bioreactors for Cell Culture Process (Fitschen et al.) -- Chapter 4. Continuous Bioprocessing for Upstream Process - Perfusion Process (Chotteau et al.) -- Chapter 5. Continuous Bioprocessing for Downstream (Gerstweiler) -- Chapter 6. Towards Digital Twin for Biopharmaceutical Processes: Concept and Progress (Ding et al.) -- Chapter 7. Integrated Process and Supply Chain Design and Optimization (Triantafyllou et al.) -- Chapter 8. Production of Complex Proteins in Plants – From Farming "]
[{"$nulls":4},"to Manufacturing (Nausch et al.) -- Chapter 9. Manufacturing of Recombinant Proteins Using Quality by Design (QbD) Methodology: Current Trend and Challenges (Shin and Landauer) -- Chapter 10. Biopharma 4.0 for Biologics Manufacturing Under Pandemic Constraints (Schmidt et al.) -- Chapter 11. Biopharma 4.0: Digital Technologies Driving Smart Manufacturing (Nargund et al.) -- Part II: Manufacturing Aspects of Cell and Gene Therapy  -- Chapter 12. Essential Aspects of Mesenchymal Stem Cell Manufacturing (Fleischhammer et al.) -- Chapter 13. Towards a Continuous Production of Human Mesenchymal Stromal Cells in a Chemically Defined Medium: Opportunities and Challenges for a Robust and Scalable Expansion Process (Tasto and Salzig) -- Chapter 14. Biomanufacturing Aspects of Gene Therapy (Warnock) -- Chapter 15. Manufacturing and Quality of Advanced Therapeutics: Cellular Therapies, CAR-T and Gene Therapies (van den Bos et al.)."]
[null,null,null,"Summary, etc","This volume “Cell Engineerring 11 - Biopharmaceutical Manufacturing: Progress, Trends and Challenges” is a source of the latest innovative research and technical development in biomanufacturing systems. It is organised into 2 parts: 1) Manufacturing of recombinant therapeutic proteins (e.g. therapeutic antibodies, biosimilars/biogenerics) and 2) Manufacturing aspects of cell and gene therapy. Each with selected chapters on the following topics for both up- and downstream, such as: Advanced process strategies, especially continuous manufacturing, Advanced culture techniques, especially single-use systems, Process transfer, scale-up/scale-down models, Processing advances/Manufacturing productivity/efficiency, Model-assisted process understanding and development/Digital Twins, Process controls and analytics, Quality control, Quality by design, Facility design and full-scale commercial systems, manufacturing technology innovation. The book comprises contributions of experts from academia and industry active in the field of cell culture development for the production of recombinant proteins, cell therapy and gene therapy, with consideration of Digital Twin´s and facility design. The knowledge and expertise of the authors cover disciplines like cell biology, engineering, biotechnology and biomedical sciences. Inevitably, some omissions will occur in the test, but the authors have sought to avoid duplications by extensive cross-referencing to chapters in other volumes of this series and elsewhere. We hope the volume provides a useful compendium of techniques for scientists in industrial and research laboratories active in this field."]
[null,"2.","Record Nr.",null,"UNINA9910437921303321"]
[null,null,"Author",null,"Nunez Alfredo A"]
[null,null,"Title",null,"Hybrid predictive control for dynamic transport problems / / Alfredo A. Nunez, Doris A. Saez, Cristian E. Cortes"]
[null,null,"Publication",null,"London, : Springer, 2013"]
[null,null,"ISBN",null,"9781283696975"]
[{"$nulls":4},"1283696975"]
[{"$nulls":4},"9781447143512"]
[{"$nulls":4},"1447143515"]
[null,null,"Designation of edition ",null,"[1st ed. 2013.]"]
[null,null,"Physical description",null,"1 online resource (182 p.)"]
[null,null,"Series statement",null,"Advances in industrial control, , 1430-9491"]
[null,null,"Dewey",null,"629.8"]
[{"$nulls":4},"629.836"]
[null,null,"Subjects",null,"Control theory"]
[null,null,"Language",null,"English"]
[null,null,"Format",null,"Language material"]
[null,null,null,"Bibliographic level","Monograph"]
[null,null,null,"General notes","Description based upon print version of record."]
[null,null,null,"Bibliography note","Includes bibliographical references and index."]
[null,null,"Formatted content note",null,"Hybrid Predictive Control: Mono-objective and Multi-objective Design -- Hybrid Predictive Control for a Dial-a-ride System -- Hybrid Predictive Control for Operational Decisions in Public Transport Systems."]
[null,null,null,"Summary, etc","Hybrid Predictive Control for Dynamic Transport Problems develops methods for the design of predictive control strategies for nonlinear-dynamic hybrid discrete-/continuous-variable systems. The methodology is designed for real-time applications, particularly the study of dynamic transport systems. Operational and service policies are considered, as well as cost reduction. The control structure is based on a sound definition of the key variables and their evolution. A flexible objective function able to capture the predictive behaviour of the system variables is described. Coupled with efficient algorithms, mainly drawn from the area of computational intelligence, this is shown to optimize performance indices for real-time applications. The framework of the proposed predictive control methodology is generic and, being able to solve nonlinear mixed-integer optimization problems dynamically, is readily extendable to other industrial processes. The main topics of this book are: ●hybrid predictive control (HPC) design based on evolutionary multiobjective optimization (EMO); ●HPC based on EMO for dial-a-ride systems; and ●HPC based on EMO for operational decisions in public transport systems. Hybrid Predictive "]
[{"$nulls":4},"Control for Dynamic Transport Problems is a comprehensive analysis of HPC and its application to dynamic transport systems. Introductory material on evolutionary algorithms is presented in summary in an appendix. The text will be of interest to control and transport engineers working on the operational optimization of transport systems and to academic researchers working with hybrid systems. The potential applications of the generic methods presented here in other process fields will appeal to a wider group of researchers, scientists and graduate students working in other control-related disciplines."]