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[null,"1.","Record Nr.",null,"UNINA9910437840803321"]
[null,null,"Titolo",null,"Gadd45 Stress Sensor Genes / / edited by Dan A. Liebermann, Barbara Hoffman"]
[null,null,"Pubbl/distr/stampa",null,"New York, NY : , : Springer New York : , : Imprint : Springer, , 2013"]
[null,null,"ISBN",null,"1-4614-8289-5"]
[null,null,"Edizione",null,"[1st ed. 2013.]"]
[null,null,"Descrizione fisica",null,"1 online resource (141 p.)"]
[null,null,"Collana",null,"Advances in Experimental Medicine and Biology, , 0065-2598 ; ; 793"]
[null,null,"Disciplina",null,"572"]
[null,null,"Soggetti",null,"Medical genetics"]
[{"$nulls":4},"Biochemistry"]
[{"$nulls":4},"Human genetics"]
[{"$nulls":4},"Gene Function"]
[{"$nulls":4},"Biochemistry, general"]
[{"$nulls":4},"Human Genetics"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Gadd45 in stress signaling, cell cycle control and apoptosis -- Gadd45 in Modulation of Solid Tumors and Leukemia -- Gadd45 Proteins: Key players of repair-mediated DNA demethylation -- Gadd45 proteins in Immunity -- Gadd45 in the liver — Signal transduction and transcriptional mechanisms -- The Role of the Gadd45 Family in the Nervous System: A focus on Neurodevelopment, Neuronal Injury, and Cognitive Neuroepigenetics -- Gadd45 stress sensors in preeclampsia -- Index."]
[null,null,null,"Sommario/riassunto","Emerging evidence indicates that the Gadd45 family of genes play a unique and critical role as sensors of stress, including genotoxic, physiological and oncogenic stress.   The stress response Gadd45 family of genes (Gadd45a, Gadd45b & Gadd45g), discovered by Dr. Liebermann and other researchers, encode for small (18 kd) nuclear/cytoplasmic proteins).  These genes are rapidly induced by a wide variety of endogenous and exogenous stress stimuli. In spite of marked similarities, Gadd45 genes are regulated differently & exhibit functional diversity.  Gadd45 are implicated in cell cycle arrest, DNA demethylation & repair, apoptosis, cell survival, genomic stability, inflammation, & in response to physiological and oncogenic stress.   Functions of Gadd45 genes are mediated by protein-protein interactions that modulate structure/function of other cellular proteins "]
[{"$nulls":4},"implicated in cell cycle regulation and the response of cells to stress; these interactions vary depending upon the biological setting including cell type, developmental stage and stress/stimulus.  Protein partners include cdc2/cyclinB1, p21, the p38/JNK stress induced kinase pathways, and PCNA/histones. The purpose of this book is to provide a comprehensive picture of the unique global role Gadd45 genes play as stress sensors & the molecular pathways involved.  ."]