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[null,"1.","Record Nr.",null,"UNINA9910437827103321"]
[null,null,"Titolo",null,"Microdialysis in drug development / / Markus Muller, editor"]
[null,null,"Pubbl/distr/stampa",null,"New York, : Springer, 2013"]
[null,null,"ISBN",null,"1-283-62448-6"]
[{"$nulls":4},"9786613936936"]
[{"$nulls":4},"1-4614-4815-8"]
[null,null,"Edizione",null,"[1st ed. 2013.]"]
[null,null,"Descrizione fisica",null,"1 online resource (341 p.)"]
[null,null,"Collana",null,"AAPS advances in the pharmaceutical sciences series, , 2210-7371"]
[null,null,"Disciplina",null,"615/.19"]
[{"$nulls":4},"616.8/04754"]
[null,null,"Soggetti",null,"Drug development"]
[{"$nulls":4},"Brain microdialysis"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"pt. 1. General aspects -- pt. 2. Specific topics."]
[null,null,null,"Sommario/riassunto","In vivo target site concentrations are probably the most important determinant of drug effects. Traditionally, linking drug concentrations to drug effects has been accomplished by modelling blood-derived data, mostly because a direct quantification of tissue concentrations has been beyond technical reach. Today, a direct measurement of target site concentrations is possible by employing microdialysis or complementary approaches such as imaging technologies. Microdialysis, initially conceived in the 1970ies, has become a standard tool in drug development. This comprehensive overview of current microdialysis technology covers general and disease-specific aspects of microdialysis by international experts in the field. It provides useful information for colleagues in academia and industry who are interested PK-PD aspects of drug development."]