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[null,"1.","Record Nr.",null,"UNISA990003648750203316"]
[null,null,"Autore",null,"MILNER, Jean Claude"]
[null,null,"Titolo",null,"Il periplo strutturale : figure e paradigma / Jean-Claude Milner ; a cura di Barbara Chitussi"]
[null,null,"Pubbl/distr/stampa",null,"Milano ; Udine : Mimesis, 2009"]
[null,null,"ISBN",null,"978-88-8483-807-0"]
[null,null,"Descrizione fisica",null,"230 p., 1 ritratto ; 21 cm"]
[null,null,"Collana",null,"Mimesis , Volti ; 42"]
[null,null,"Disciplina",null,"149.96"]
[null,null,"Soggetti",null,"Strutturalismo"]
[null,null,"Collocazione",null,"II.1.D. 5542"]
[null,null,"Lingua di pubblicazione",null,"Italiano"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,"2.","Record Nr.",null,"UNISALENTO991003078409707536"]
[null,null,"Autore",null,"Brazzale, A. R. (Alessandra R.)"]
[null,null,"Titolo",null,"Applied asymptotics : case studies in small-sample statistics / A.R. Brazzale, A.C. Davison, N. Reid"]
[null,null,"Pubbl/distr/stampa",null,"Cambridge : Cambridge University Press, c2007"]
[null,null,"ISBN",null,"9780521847032"]
[null,null,"Descrizione fisica",null,"viii, 236 p. : ill. ; 26 cm"]
[null,null,"Collana",null,"Cambridge series on statistical and probabilistic mathematics"]
[null,null,"Disciplina",null,"519.5"]
[null,null,"Soggetti",null,"Statistical hypothesis testing - Asymptotic theory"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Nota di bibliografia","Include bibliografia e indice"]
[null,"3.","Record Nr.",null,"UNINA9910373919103321"]
[null,null,"Titolo",null,"Protein Allostery in Drug Discovery / / edited by Jian Zhang, Ruth Nussinov"]
[null,null,"Pubbl/distr/stampa",null,"Singapore : , : Springer Singapore : , : Imprint : Springer, , 2019"]
[null,null,"ISBN",null,"981-13-8719-2"]
[null,null,"Edizione",null,"[1st ed. 2019.]"]
[null,null,"Descrizione fisica",null,"1 online resource (XII, 384 p. 103 illus., 82 illus. in color.)"]
[null,null,"Collana",null,"Advances in Experimental Medicine and Biology, , 0065-2598 ; ; 1163"]
[null,null,"Disciplina",null,"615.19"]
[null,null,"Soggetti",null,"Pharmaceutical technology"]
[{"$nulls":4},"Proteins"]
[{"$nulls":4},"Biomedical engineering"]
[{"$nulls":4},"Pharmaceutical Sciences/Technology"]
[{"$nulls":4},"Protein Science"]
[{"$nulls":4},"Protein Structure"]
[{"$nulls":4},"Biomedical Engineering/Biotechnology"]
[{"$nulls":4},"Tecnologia farmacèutica"]
[{"$nulls":4},"Llibres electrònics"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,"Nota di contenuto",null,"Chapter 1. Allostery in Drug Development -- Chapter 2. Dynamic Protein Allosteric Regulation and Disease -- Chapter 3. Protein Allostery in Rational Drug Design -- Chapter 4. Progress in Allosteric Database -- Chapter 5. Correlation between Allosteric and Orthosteric Sites -- Chapter 6. Characteristics of Allosteric Proteins, Sites and Modulators -- Chapter 7. Advances in the Computational Identification of Allosteric Sites and Pathways in Proteins -- Chapter 8. Advances in NMR Methods to Identify Allosteric Sites and Allosteric Ligands -- Chapter 9. Interrogating Regulatory Mechanisms in Signal-ling Proteins by Allosteric Inhibitors and Activators: A Dynamic View through the Lens of Residue Interaction Network -- Chapter 10. GPCR Allosteric Modulator Discovery -- Chapter 11. Allosteric Small-Molecule Serine/Threonine Kinase Inhibitors -- Chapter 12. Allosteric regulation of protein kinases downstream of PI3-kinase signaling. Chapter 13. Allosteric Modulators of Protein-Protein Interactions (PPIs) -- Chapter 14. Allosteric Modulation of Intrinsically Disordered Proteins -- Chapter 15. Engineering Allostery into Proteins."]
[null,null,null,"Sommario/riassunto","The book focuses on protein allostery in drug discovery. Allosteric regulation, ʹthe second secret of lifeʹ, fine-tunes virtually most biological processes and controls physiological activities. Allostery can both cause human diseases and contribute to development of new therapeutics. Allosteric drugs exhibit unparalleled advantages compared to conventional orthosteric drugs, rendering the development of allosteric modulators as an appealing strategy to improve selectivity and pharmacodynamic properties in drug leads. The Series delineates the immense significance of protein allostery—as demonstrated by recent advances in the repertoires of the concept, its mechanistic mechanisms, and networks, characteristics of allosteric proteins, modulators, and sites, development of computational and experimental methods to predict allosteric sites, small-molecule allosteric modulators of protein kinases and G-protein coupled receptors, engineering allostery, and the underlying role of allostery in precise medicine. Comprehensive understanding of protein allostery is expected to guide the rational design of allosteric drugs for the treatment of human diseases. The book would be useful for scientists and students in the field of protein science and Pharmacology etc. ."]