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[null,null,"Titolo",null,"Actin Polymerization in Apicomplexan : A Structural, Functional and Evolutionary Analysis / / edited by Avinash Kale"]
[null,null,"Pubbl/distr/stampa",null,"Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2019"]
[null,null,"ISBN",null,"981-13-7450-3"]
[null,null,"Edizione",null,"[1st ed. 2019.]"]
[null,null,"Descrizione fisica",null,"1 online resource (XI, 101 p. 11 illus. in color.)"]
[null,null,"Disciplina",null,"616.96"]
[null,null,"Soggetti",null,"Parasitology"]
[{"$nulls":4},"Biomechanics"]
[{"$nulls":4},"Proteins"]
[{"$nulls":4},"Bioinformatics"]
[{"$nulls":4},"Protein Biochemistry"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Nota di bibliografia","Includes bibliographical references."]
[null,null,"Nota di contenuto",null,"Chapter 1. Synthesis and Characterization of nano Apicomplexan motility: A cellular perspective particles -- Chapter 2. Introduction: Gliding Motility- The model and the mechanism -- Chapter 3. Actin: The central ubiquitous player in the phenomenon -- Chapter 4. Formin: The multidomain elongator of polymer -- Chapter 5. Profilin: The associates of Formin -- Chapter 6. ADF (Actin Depolymerizing Factor): The breaker of the polymer in homeostasis -- Chapter 7. Cyclase associated protein (CAP): The silent worker -- Chapter 8. Capping Protein (CP): The formin competitor -- Chapter 9. Coronin: An Overview -- Chapter 10. Mathematical Model: A revelation of synergistic cross talks between the actin regulators -- Chapter 11. Evolution: The hallmarks of Gliding motility in apicomplexan."]
[null,null,null,"Sommario/riassunto","This book discusses in detail the structural, evolutionary and functional role of actin and its regulatory proteins in gliding motility in apicomplexan organisms, a unique phenomenon found in actin-myosin cytoskeletal elements. The book also explores the potential of different actin regulators, namely formin, profilin, actin depolymerization factor (ADF), capping proteins (CPα and CPβ), cyclase-associated protein (CAP) and coronin 13–24 as potential drug targets against malaria. As the chief components of the gliding motor, the actin-regulator proteins are characterized by unique features that make them promising targets for structure-based drug design. Lastly, the book proposes a "]
[{"$nulls":4},"mathematical model, based on kinetic data mining, to help understand the most vital regulators for actin polymerization dynamics."]