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[null,"1.","Record Nr.",null,"UNINA9910349476303321"]
[null,null,"Titolo",null,"Chromosome Translocation / / edited by Yu Zhang"]
[null,null,"Pubbl/distr/stampa",null,"Singapore : , : Springer Singapore : , : Imprint : Springer, , 2018"]
[null,null,"ISBN",null,"9789811305931"]
[{"$nulls":4},"981-13-0593-5"]
[null,null,"Edizione",null,"[1st ed. 2018.]"]
[null,null,"Descrizione fisica",null,"1 online resource (V, 168 p. 29 illus., 27 illus. in color.)"]
[null,null,"Collana",null,"Advances in Experimental Medicine and Biology, , 0065-2598 ; ; 1044"]
[null,null,"Disciplina",null,"611.01816"]
[{"$nulls":4},"599.935"]
[null,null,"Soggetti",null,"Human genetics"]
[{"$nulls":4},"Cytology"]
[{"$nulls":4},"Human Genetics"]
[{"$nulls":4},"Cell Biology"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,"Nota di contenuto",null,"Chapter 1: Historical and clinical overview of chromosome translocations -- Chapter 2: Next generation sequencing to identify chromosome translocation -- Chapter 3: The experimental models to study chromosome translocations -- Chapter 4: High throughput translocation sequencing to identify mechanistic factors shaping translocatome -- Chapter 5: Live cell imaging to study chromosome translocation -- Chapter 6: CRISPR/Cas9 to induce chromosome translocation in vivo -- Chapter 7: Generation of DNA double strand breaks (DSBs) -- Chapter 8: The role of DSB response pathway in regulating chromosome translocation -- Chapter 9: DSB repair and ligation of chromosome translocation -- Chapter 10: 3D genome organization defines the chromosome translocation pattern -- Chapter 11: Mechanisms of chromosome deletion -- Chapter 12: Chromothripsis: The role of DNA double strand break form on repair pathway selection."]
[null,null,null,"Sommario/riassunto","This volume discusses various aspects of mechanisms and methodologies of chromosome translocations, ranging from a historical and clinical overview of chromosome translocations to the rapid development of the next-generation sequencing technologies, which has dramatically increased our understanding of the spectrum of chromosome translocations in human diseases. The book also introduces the mechanistic studies on chromosome deletions and their "]
[{"$nulls":4},"implications in cancer, and discusses the mechanisms of regulating chromothripsis, a unique complex type of chromosome translocation. It is a valuable resource for students and researchers alike, providing insights into chromosome translocations and, potentially, other genomic aberrations involved in understanding and curing human diseases."]