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[null,"1.","Record Nr.",null,"UNINA9910299230003321"]
[null,null,"Autore",null,"Hŏ Kŭm-p'a"]
[null,null,"Titolo",null,"Protein Homology Detection Through Alignment of Markov Random Fields : Using MRFalign / / by Jinbo Xu, Sheng Wang, Jianzhu Ma"]
[null,null,"Pubbl/distr/stampa",null,"Cham : , : Springer International Publishing : , : Imprint : Springer, , 2015"]
[null,null,"ISBN",null,"3-319-14914-8"]
[null,null,"Edizione",null,"[1st ed. 2015.]"]
[null,null,"Descrizione fisica",null,"1 online resource (59 p.)"]
[null,null,"Collana",null,"SpringerBriefs in Computer Science, , 2191-5768"]
[null,null,"Disciplina",null,"004"]
[{"$nulls":4},"005.55"]
[{"$nulls":4},"519.5"]
[{"$nulls":4},"570285"]
[null,null,"Soggetti",null,"Bioinformatics"]
[{"$nulls":4},"Mathematical statistics"]
[{"$nulls":4},"Statistics"]
[{"$nulls":4},"Computational Biology/Bioinformatics"]
[{"$nulls":4},"Probability and Statistics in Computer Science"]
[{"$nulls":4},"Statistics for Life Sciences, Medicine, Health Sciences"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references."]
[null,null,"Nota di contenuto",null,"Introduction -- Method -- Software -- Experiments and Results -- Conclusion."]
[null,null,null,"Sommario/riassunto","This work covers sequence-based protein homology detection, a fundamental and challenging bioinformatics problem with a variety of real-world applications. The text first surveys a few popular homology detection methods, such as Position-Specific Scoring Matrix (PSSM) and Hidden Markov Model (HMM) based methods, and then describes a novel Markov Random Fields (MRF) based method developed by the authors. MRF-based methods are much more sensitive than HMM- and PSSM-based methods for remote homolog detection and fold recognition, as MRFs can model long-range residue-residue interaction. The text also describes the installation, usage and result interpretation of programs implementing the MRF-based method."]