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[null,null,"Titolo",null,"Voltage-gated Sodium Channels: Structure, Function and Channelopathies / / edited by Mohamed Chahine"]
[null,null,"Pubbl/distr/stampa",null,"Cham : , : Springer International Publishing : , : Imprint : Springer, , 2018"]
[null,null,"ISBN",null,"3-319-90284-9"]
[null,null,"Edizione",null,"[1st ed. 2018.]"]
[null,null,"Descrizione fisica",null,"1 online resource (X, 450 p. 80 illus., 55 illus. in color.)"]
[null,null,"Collana",null,"Handbook of Experimental Pharmacology, , 0171-2004 ; ; 246"]
[null,null,"Disciplina",null,"615"]
[null,null,"Soggetti",null,"Pharmacology"]
[{"$nulls":4},"Human genetics"]
[{"$nulls":4},"Human physiology"]
[{"$nulls":4},"Proteins"]
[{"$nulls":4},"Pharmacology/Toxicology"]
[{"$nulls":4},"Human Genetics"]
[{"$nulls":4},"Human Physiology"]
[{"$nulls":4},"Protein Structure"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,"Nota di contenuto",null,"Preface -- Part I -- Evolution of voltage-gated sodium channels -- 1. Evolutionary History of Voltage-Gated Sodium Channels -- 2. Mining Protein Evolution for Insights into Mechanisms of Voltage-Dependent Sodium Channel Auxiliary Subunits. - Part II. The structural basis of sodium channel function -- 3. Structural and Functional Analysis of Sodium Channels Viewed from an Evolutionary Perspective -- 4. The Cardiac Sodium Channel and Its Protein Partners -- 5. : Posttranslational Modification of Sodium Channels -- 6. Sodium Channel Trafficking -- 7. pH Modulation of Voltage-Gated Sodium Channels -- 8. Regulation of Cardiac Voltage-Gated Sodium Channel by Kinases: Roles of Protein Kinases A and C -- Part III. Drugs and toxins interactions with sodium channels -- 9. Toxins That Affect Voltage-Gated Sodium Channels -- 10. Mechanisms of Drug Binding to Voltage-Gated Sodium Channels -- 11. Effects of Benzothiazolamines on Voltage-Gated Sodium Channels -- 12. Structural Models of Ligand-Bound Sodium Channels -- 13. Selective Ligands and Drug Discovery Targeting the Voltage-Gated Sodium Channel Nav1.7 -- Part IV. Pathophysiology of sodium channels -- 14. Sodium Channelopathies of "]
[{"$nulls":4},"Skeletal Muscle -- 15. Cardiac Arrhythmias Related to Sodium Channel Dysfunction -- 16. Translational Model Systems for Complex Sodium Channel Pathophysiology in Pain -- 17. Gating Pore Currents in Sodium Channels -- 18. Calculating the Consequences of Left-Shifted Nav Channel Activity in Sick Excitable Cells -- 19. Voltage-Gated Sodium Channel b Subunits and Their Related Diseases. ."]
[null,null,null,"Sommario/riassunto","This book provides a timely state-of-the-art overview of voltage-gated sodium channels, their structure-function, their pharmacology and related diseases. Among the topics discussed are the structural basis of Na+ channel function, methodological advances in the study of Na+ channels, their pathophysiology and drugs and toxins interactions with these channels and their associated channelopathies."]